Clinical trials: Healthy Gut Microbiota
Healthy
Essential Oil-Based Product System for Digestive Support
This study aims to evaluate the efficacy of specific essential oils. Efficacy will be evaluated through changes, if any, to hsCRP, gene expression, and standard hematologic and metabolic parameters, as well as subjective health…
- Trial name
- NCT07653815
- Testing
- essential oil supplement, Essential Oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Nutrition, Healthy, Gastrointestinal Microbiome
The Effects of a Nutritional Supplement on Nutrient Status and Quality of Life
This study is a randomized, double-blind, placebo-controlled study of N=120 apparently healthy men and women. The purpose of this study is to assess the effect of a novel dietary supplement on blood markers of nutrient status…
- Conditions
- Nutrition, Healthy, Gastrointestinal Microbiome, Healthy Aging
- Trial name
- NCT06332898
- Testing
- AG1 - Nutritional Supplement
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Athletic Greens International
Healthy
Impact of Consuming a Plant-based Enriched Meal on the Adult Gut Microbiome
The aim of this study is to evaluate the impact of a diversified plant-based meal on the gut microbiome and its composition.
- Trial name
- NCT05459662
- Testing
- oat based porridge, plant based preparation
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy Volunteer
A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers
This is a randomized (1:1), double-blind, double-dummy, phase I study to compare the effects of Omadacycline versus Moxifloxacin on gut microbiota and the resistomes in healthy adult volunteers.The study consists of 3 phases…
- Trial name
- NCT06462326
- Testing
- Moxifloxacin Oral Tablet, Omadacycline Oral Tablet
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zai Lab (Hong Kong), Ltd.
Healthy
A Novel Fecal Sample Collection Method for Metagenomic Analyses
This is an open-label, one-arm, one-time-point pilot assessing the intra- and inter-group variation of gut microbiome collection methods and storage conditions using metagenomic sequencing for analysis.
- Trial name
- NCT05172414
- Testing
- No intervention
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Onegevity Health
Gut Microbiota Modulation
The Role of Probiotic LH76 in Human Gut Health
This study aims to evaluate the safety and efficacy of the probiotic LH76 as a dietary supplement in healthy adults. The research will assess its effects on gut microbiota composition, intestinal health, and immune function…
- Trial name
- NCT06875375
- Testing
- probiotic LH76
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Healthy Adult Participants, Gut Microbiomes
DORA - A Study Using Digital Health Tools/Platform to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals
The DORA study is a single-arm, open-label, interventional exploratory study designed to evaluate the impact of a synbiotic-containing senior milk powder on the gut microbiome and selected biological, physiological, and digital…
- Conditions
- Healthy Adult Participants, Gut Microbiomes, AI
- Trial name
- DORA (NCT07575529)
- Testing
- Synbiotic Nutritional Product
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Healthy Infants
Colonisation Resistance Study
This study is initiated to investigate the effect of infant formulas with added specific prebiotic oligosaccharides on the reduction of specific potential pathogens and/or toxins.
- Trial name
- ColoR (NCT01507935)
- Testing
- Regular non-hydrolysed cow's milk
- Where
- 2 sites in Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Microbial Colonization
Ex Vivo Study of the Mechanism of Action of Active Ingredients on the Intestinal Microbiota
To design and understand the mechanism of action of different combinations of nutraceuticals coupling bacteria, fibers and polyphenols, which can act on the 4 pillars simultaneously via an innovative ex-vivo model approach…
- Trial name
- NCT04895774
- Testing
- Probiotic strains, Polyphenols, Fibers
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Nutri & Co
Healthy Infants
Efficacy of a New Infant Formula Composition on Gut Health in Infants
The aim of this study is to investigate potential health benefits of the experimental formula. The main objective is whether the experimental formula elevates the relative abundance of Bifidobacterium in stool samples after 10…
- Trial name
- NCT07242508
- Testing
- Infant Formula, Infant Formula with bioactive ingredients
- Where
- Bulgaria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina
Gut Microbiota, Gastrointestinal Symptoms
The Effects Of HMO On The Faecal Microbiota And On Gastrointestinal Symptoms In Healthy Volunteers
The study is a randomised, placebo-controlled, double-blind, parallel, dose-finding study with healthy volunteers. A total of 100 male and female volunteers will be included.
- Trial name
- HMO-VOL (NCT01927900)
- Testing
- HMO, Glucose
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glycom A/S
Healthy Adults
Adult HMO Supplementation and the Gut Microbiome
The goal of this study is to assess the impact of Layer Origin's SuperHMO prebiotic formulation on the healthy adult gut microbiome.
- Trial name
- NCT06570330
- Testing
- SuperHMO, Non-GMO corn Maltodextrin, Rapid Absorption
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Healthy Adult Females, Healthy Adult Male
Effects of Two Different Lion's Mane Extracts (Lions Mane Fruiting Body & Lions Mane Fruiting Body With Mycellium) on Cognitive Performance, Subjective Affect, Serum Biomarkers, and Gut Microbiota in Healthy Adults
A randomized, double-blind, placebo-controlled, parallel-arm study design, of healthy men and women assigned to one of three groups: 1 gram/day of MycothriveTM Nordic origin fruiting body lion's mane (M-LM), 1 gram/day of a…
- Trial name
- NCT07405957
- Testing
- Lion Mane (Hericium erinaceus) fruiting body extract - Nordic Origin, Lions Mane (Hericium erinaceus) Fruiting body and mycelium
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Applied Food Sciences Inc.
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy Subjects
Effect of Proton Pump Inhibitors on Gut Microbiota Composition and Metabolites in Healthy Subjects Using CapScan
This study is designed to evaluate the effect of proton pump inhibitors on the regional composition of the gut microbiota and metabolic profiles of health volunteers using the CapScan collection capsule.
- Trial name
- NCT07054593
- Testing
- CapScan
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Envivo Bio Inc
Beneficial Bacteria in Gut
Color Synbiotics Study
This study is initiated to investigate the effect of infant formula with added specific synbiotics mixture on proportion of beneficial bacteria.
- Trial name
- NCT01813175
- Testing
- Regular non-hydrolysed cow's milk I, Regular non-hydrolysed cow's milk II, Regular non-hydrolysed cow's milk - control
- Where
- 3 sites in Thailand
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Healthy Subjects, Pre-diabetes
Red Raspberry Polyphenols on Gut Microbiome
The primary objective aims are to assess the effects of regular consumption of red raspberries (RRB) with and without fructooligosaccharide (FOS) on the composition of the gut microbiota after 4 week intake and in parallel…
- Trial name
- RRB2 (NCT03049631)
- Testing
- Raspberry and fructooligosaccharide, Raspberry
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Healthy Subjects
Safety and Efficacy Study of Different DAV132 Dose Regimens in Healthy Volunteers
The purpose of this study is to evaluate whether different DAV132 dose regimens are safe and effective for capturing fecal residues of moxifloxacin in healthy volunteers.
- Trial name
- NCT02917200
- Testing
- Moxifloxacin, DAV132, Negative control
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Intestinal Bacteria Flora Disturbance
Allium Extracts on the Intestinal Microbiota in Healthy Resident Volunteers.
To evaluate the effect of daily consumption of a combination of garlic and onion extracts on the intestinal microbiota and the production of short chain fatty acids in elderly healthy volunteers living in a residence.
- Trial name
- NCT05016999
- Testing
- Garlic and onion concentrate
- Where
- Spain
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- DOMCA S.A.