Clinical trials: Healthy Gut Microbiota
Healthy, Overweight and Obesity
Fiber-enriched Croissant Consumption and Effects on Metabolic Status, Appetite and Gut Microbiota
The aim of this study is to evaluate the effect of a daily consumption for 2 weeks of a sourdough croissant enriched with dietary fibers vs a control sourdough croissant with no fiber added on daily energy intakes, fasting…
- Trial name
- CROMA (NCT04999280)
- Testing
- Fiber Croissant (FIBCRO) Group, Control Croissant (CONCRO) Group
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Federico II University
Healthy
Impact of Consuming a Plant-based Enriched Meal on the Adult Gut Microbiome
The aim of this study is to evaluate the impact of a diversified plant-based meal on the gut microbiome and its composition.
- Trial name
- NCT05459662
- Testing
- oat based porridge, plant based preparation
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Taking Sialic Acid to Regulate the Gut Microbiota, Healthy
A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects
This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital).
- Trial name
- MFMOSA (NCT07162662)
- Testing
- Oral Sialic acid
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Xiaolong Li
Diet, Food and Nutrition
Impacts of Durian Consumption on Human Microbiome and Metabolome in Healthy Staff Volunteers
This clinical study investigates the impacts of daily durian consumption on gut microbiota, gut microbial metabolites, and host metabolome in healthy individuals.
- Trial name
- DURIOME (NCT06194084)
- Testing
- Two-sequence of durian pulp doses (100 g and 200 g)
- Where
- Singapore
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
Crohn Disease, Ulcerative Colitis
OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome
Study Aims: To analyze stool specimens to test and validate the CalproLab assay against the predicate PhiCal in order to determine performance characteristics. And to correlate Calpro levels to the gut microbiome composition.
- Conditions
- Crohn Disease, Ulcerative Colitis, Irritable Bowel Syndrome, Celiac Disease
- Trial name
- OptiCal (NCT03051204)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy Volunteers
The Effects of the Synbiotic Ecologic 825/scFOS on Intestinal Barrier Function and Immune Modulation
In the present pilot study, the investigators will study the effects of a novel synbiotic, which is a mix of probiotics (Ecologic 825) in the presence of a prebiotic (short chain fructo-oligosaccharide (scFOS)), on mucosal…
- Trial name
- CRIB (NCT02018900)
- Testing
- Ecologic 825/scFOS
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Digestive Discomfort, Constipation
Bacillus Coagulans Effect on Gastrointestinal Function in Healthy Adults.
A single centre, double-blind, placebo-controlled study to evaluate the effect of the consumption of Bacillus coagulans at a daily dose of 1 x 10⁹ CFU on bowel habits, intestinal microbiota and gastrointestinal symptoms in…
- Conditions
- Digestive Discomfort, Constipation, Microbiota
- Trial name
- NCT06644001
- Testing
- Bacillus coagulans GBI-30,6086 (BC GBI-30)
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Kerry Group P.L.C
Healthy Adult
Effect of Bifidobacterium Animalis Subsp. Lactis Bi66 Supplementation on Gut Function in Healthy Adults
The goal of this clinical trial is to learn the effect of Bifidobacterium animalis subsp. lactis Bi66 supplementation on gut function in healthy adults. The main questions it aims to answer are: 1.
- Trial name
- NCT06740500
- Testing
- Probiotic
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Adult Healthy Volunteers
O-LIVE: Impact of a Portuguese Olive Oil in Health Biomarkers
This research project, approved and funded, is part of a larger project, entitled "Healthy Soil for Food", which completes several work packages, one of which is a clinical research submitted to Ethics Committee entitled "O-LIVE…
- Trial name
- O-LIVE (NCT05852275)
- Testing
- Olive-oil
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Católica Portuguesa
Gut Microbiota Modulation
STUDY OF THE EFFECTS OF L. CASEI DG® (ENTEROLACTIS BABY) IN HEALTHY PRETERM AND FULL-TERM INFANTS.
The goal of this clinical trial was to learn whether giving Enterolactis Baby®, a probiotic food supplement containing Lactobacillus casei DG® (under the new taxonomical denomination: Lacticaseibacillus paracasei DG, CNCM…
- Trial name
- NCT07882537
- Testing
- Enterolactis Baby® drops
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Alfasigma S.p.A.
Thinness, Health Behavior
Phenotypic Characteristics of Superlean Individuals Including Gut Microbiome
The goal of this observational study is to build on our previous work to further characterise the phenotype of superlean individuals (BMI < 18.5) when compared to normal BMI people (BMI 21.5 to 25).
- Trial name
- NCT05804929
- Testing
- Observation without intervention
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Healthy Participants
The Effect of Drinking-Water pH on the Human Gut Microbiota
This study evaluates the effect of alkaline (pH=9) versus neutral (pH=9) drinking-water on the gut microbiota of healthy male volunteers.
- Trial name
- NCT02917616
- Testing
- Alkaline drinking-water, Neutral drinking-water
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Novo Nordisk Foundation Center for Basic Metabolic Research
Healthy
Probiotics (L. Gasseri, B. Bifidum, B. Longum) on Immune and Intestinal Health in Healthy Older Adults
The purpose of this study is to determine whether healthy older adults, aged 65 to 80 years, consuming a probiotic each day for three weeks will have improved immune strength and digestive health.
- Trial name
- NCT01662206
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy
Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel
This study aims to evaluate the effects of a dual Bifidobacterium longum probiotic formulation (dipro-O and dipro-X) on sleep quality, stress responses, and gut microbiota stability in healthy adults during short-term travel.
- Trial name
- NCT07511855
- Testing
- Probiotic
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Min-Tze LIONG
Healthy Infants
HMOs on Infant Gut Microbiota Modulation and Development of the Immune System in Healthy Infants
The goal of this clinical trial is to learn how a mixture of human milk oligosaccharides impacts the development of the infant microbiota, the immune maturation and how the interaction between the microbiota and immune maturation…
- Trial name
- BELIEF (NCT06631937)
- Testing
- Human Milk Oligosaccharides
- Where
- 2 sites in Denmark
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy, Gastrointestinal Diseases
Prebiotic Effects on Gut Microbiota, Gut Comfort and Immune Function
Human Milk Oligosaccharides (HMOs) are the third most abundant class of nutrients in human milk. Studies investigating the effects of dietary HMOs in infants have shown various health and developmental benefits such as the…
- Trial name
- NCT06094153
- Testing
- HMO 1, HMO 2
- Where
- Singapore
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Kyowa Hakko Bio Co., Ltd.
Rosacea
Characterization of the Facial and Gut Microbiome in Rosacea
Questionnaires will be completed by each member of the twin set. A board-certified dermatologist will examine each member to categorize the type and severity of their rosacea.
- Trial name
- NCT03228927
- Testing
- comparison of twin A to twin B
- Volunteers
- 150 people
- Sponsor
- The Acne Cure Alliance
Healthy
Resistant Maltodextrin Supplementation: Gastrointestinal Health
Resistant maltodextrin (RMD) is an indigestible water soluble fiber that increases fecal bulk by enhancing growth of specific microbial populations; however the effect of RMD on bifidobacteria and total fecal weight is not clear.
- Trial name
- DEX (NCT02733263)
- Testing
- 15 g RMD, 25 g RMD, 0 g RMD
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Adult Participants
Probiotic Research for Mental Health in Adult Volunteers
This randomized, double-blind, placebo-controlled pilot study will evaluate the effects of four weeks of supplementation with a probiotic on mental health in healthy adults aged 18-30 years.
- Trial name
- NCT07751614
- Testing
- Probiotic
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Healthy
Differences Between Coffee and Non-coffee Drinkers in the Gut Microbiome and Microbiota-Gut-Brain Axis
The aim of this study is to investigate the potential of coffee to act as a prebiotic to alter gut microbiota and improve mood, memory and cognitive performance.
- Trial name
- NCT05927103
- Where
- Ireland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University College Cork