Clinical trials: Healthy Individuals.
Type 1 Diabetes Mellitus
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
We will perform blood sugar studies to assess changes in metabolic (biochemical processes that occur within us) profiles associated with high blood sugar and diabetes.
- Trial name
- DP3 (NCT01823406)
- Testing
- Euglycemic clamp (normal blood sugar clamp) for 4 hours, hyperglycemic clamp (elevated blood sugar to 300) for 4 hours
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
COPD, Healthy Subjects
Sublingual Tonometry to Assess Tissue Perfusion in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Sublingual positioning of a silicon capillary system is applied. After 15 min, while the individual is in resting position with closed mouth and normal tidal breathing through the nose is performed, the silicon capillary system…
- Trial name
- subton (NCT01169506)
- Testing
- sublingual silicon capillary
- Where
- Hungary
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Szeged University
Healthy Individuals With Hamstring Tightness
The Immediate Effects Of Thoracolumbar Fascia Inhibition And Suboccipital Muscle Inhibition
This randomized controlled trial aimed to compare the immediate effects of two self-myofascial release techniques-suboccipital muscle inhibition and thoracolumbal fascia inhibition-on hamstring flexibility, spinal range of…
- Trial name
- NCT07096076
- Testing
- Thoracolumbar fascia inhibition, Suboccipital inhibition group, hamstring stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
SARS-CoV-2 Infection, COVID-19
Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals.
- Trial name
- NCT04368728
- Testing
- BNT162b1, BNT162b2, BNT162b2SA
- Where
- 175 sites in United States, Argentina and 4 more
- Volunteers
- 46,969 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Healthy Overweight/Obese
The Metabolic Effects of Oral Tributyrin Administration
The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo.
- Trial name
- TRIMET (NCT07463495)
- Testing
- tributyrin, Control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Heart Failure, Diabetes
SHAPES: Supporting Multimorbid Older People
The Smart \& Healthy Ageing through People Engaging in Supportive Systems (SHAPES) Innovation Action is a Horizon 2020, EU-wide project looking at how technology can enable the older population to live healthier lives at home.
- Conditions
- Heart Failure, Diabetes, Diabetes Mellitus
- Trial name
- NCT05249062
- Testing
- SHAPES app
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Prof Michael Scott
Healthy Control Subjects
Impact of Spaced iTBS on Plasticity in the Motor Cortex
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years.
- Trial name
- STEP-MC (NCT06735794)
- Testing
- Compressed iTBS, Spaced iTBS
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy Middle-aged Subjects, Age Range Was 18 to 31 Years
Impact of Exercise on Retinal Microvascular Regulation Measured by Dynamic Vessel Analysis in Healthy Individuals
Objective The investigators assessed the acute impact of physical exercise on retinal vessel regulation. This might be of clinical importance if retinal vessel regulation is examined with the very sensitive method of the dynamic…
- Conditions
- Healthy Middle-aged Subjects, Age Range Was 18 to 31 Years, Caucasian Whites, Males and Females
- Trial name
- NCT01297868
- Testing
- exercise
- Where
- Germany
- Sponsor
- University Medicine Greifswald
Healthy
Comparison of Telerehabilitation and Video Basics and Exercise in Older Adult Individuals
Researchers could not find a study in the literature examining the effectiveness of different technological methods in exercise practices in older adults.
- Trial name
- NCT06441396
- Testing
- Telerehabilitation, Video-based rehabilitation (VTR)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Closed-loop Brain Stimulation
Closed-loop tES-non-invasive Stimulation
The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers.
- Trial name
- CLIBM (NCT07671079)
- Testing
- Transcranial low intensity focused ultrasound (FUS), transcranial electrical stimulation, Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Uric Acid, Cardiovascular Diseases
Acute Effects of Tart Cherry on Uric Acid and Biomarkers of CVD Risk in Healthy Individuals
This study aims to provide evidence as to whether consumption of tart cherry juice can reduce the risk of gout and cardiovascular disease (CVD) in an acute context.
- Conditions
- Uric Acid, Cardiovascular Diseases, Gout
- Trial name
- NCT04960527
- Testing
- Tart cherry juice, Water
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Immune Responses After Human Subject Challenge With Sand Fly Bites
Sand flies can carry the infection leishmaniasis (a parasite). The purpose of this study is to evaluate the human immune response to uninfected laboratory raised sand fly bites and select from the immune response to sand fly…
- Trial name
- NCT01289977
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Healthy
Magnetocardiography (MCG) in Asymptomatic Individuals - Pilot Trial
The purpose of this research study is to perform serial magnetocardiographs (MCG)and cardiovascular risk factor assessments on individuals with no symptoms or history of heart disease.
- Trial name
- NCT00572442
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Depression Disorder, Healthy
The Neural Representation of Self in Depression Patients
To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning.
- Trial name
- NCT03551041
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Hyperlipidemia
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism
This study will evaluate the effects of encapsulated botanical extracts, previously shown to inhibit the enzyme diacylglycerol-acyltransferase-1 (DGAT-1) in vitro, on fasting and postprandial lipid metabolism during an oral fat…
- Trial name
- NCT02366156
- Testing
- Low Dose Grape Blend, High Dose Grape Blend
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Influenza
The Immune Response to Influenza Vaccinations in Elderly Individuals
The aim of this study is to characterize the immune profile of frail and healthy aged individuals and investigate their immune responsiveness including the response to influenza vaccine over an 18-month period.
- Trial name
- NCT03266237
- Testing
- Vaxigrip®
- Where
- 9 sites in Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Healthy Subjects
Neurophysiologic Effects of Cervical Spinal Manipulation in Asymptomatic Individuals
This study had the goal of analyse the neurophysiologic effects of both mechanical and manual cervical manipulation, in asymptomatic individuals.
- Trial name
- NCT03463343
- Testing
- Cervical spine manual manipulation, Cervical spine mechanical manipulation
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Healthy
Gait Variability in Healthy Youngs
Three hundred healthy individuals will be participants of the study. Participants will evaluate with the following assessment tools: Demographic datas; age, gender, height, body mass, will be recorded.
- Trial name
- NCT02988284
- Testing
- No intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy
Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-Rich Foods
There are two primary objectives to be addressed in this study: to assess the differential response in bioavailability and metabolic pathways between lean and obese individuals exposed to acute, short term (14 day), and long-term…
- Trial name
- NCT02197754
- Testing
- Controlled diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center