Clinical trials: Healthy Male
Healthy
Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
To find out if the blood level of lenalidomide can be changed when a drug that prevents p-glycoprotein (a protein naturally present in the body that helps carry substances across cell membranes that is found in many parts of the…
- Trial name
- NCT01712828
- Testing
- Lenalidomide, Quinidine, Temsirolimus
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Celgene
Ulcerative Colitis, Crohn Disease
HMPL004-6599 Phase I Dose-escalating Study
To assess the safety and tolerability of single and multiple doses of HMPL004-6599 in healthy male volunteers
- Trial name
- NCT03597971
- Testing
- HMPL004-6599
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Nutrition Science Partners Limited
Healthy Men
Electroencephalography Study Investigating the Effects of Vortioxetine in Healthy Male Subjects
To explore a neurophysiological marker (electroencephalography) of cognitive effect of vortioxetine
- Trial name
- NCT02072278
- Testing
- Vortioxetine 10 mg, Vortioxetine 20 mg, Escitalopram 15 mg
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Atopic Dermatitis
The Mass Balance and Biotransformation Study of [14C] VC005 in Chinese Healthy Adult Male Volunteers
This study was designed to evaluate the mass balance and biotransformation after single-dose of [14C]VC005 orally in Chinese healthy male volunteers.
- Trial name
- NCT06974292
- Testing
- [14C]VC005
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Rivastigmine Toxicity
A Double-Blind, Placebo-controlled Crossover Study of Repeat Rivastigmine Administration in Healthy Male Volunteers
Rivastigmine is a carbamate, approved by the FDA for the treatment of mild to moderate dementia associated with Alzheimer's and Parkinson's diseases.
- Trial name
- RIVA-1 (NCT00624663)
- Testing
- Rivastigmine
- Where
- 2 sites in Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy
Study to Investigate Safety, Tolerability and Pharmacokinetics With Single and Multiple Ascending Doses of AZD1446
This study is designed to evaluate the safety, tolerability and PK of AZD1446 in Subjects when given as multiple dose administration for either 7 Days (Day 1 single dose, Day 2-6 multiple doses) in Part A and optionally at…
- Trial name
- NCT00902993
- Testing
- AZD1446
- Where
- 2 sites in Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteer
The Safety and Pharmacokinetics Study of TAKC-02 Inhalation Solution in Healthy Adult Males.
MEX3B is an RNA-binding protein that is conserved in many animal species and has wide range of biological function. The MEX3B protein is deeply involved in the expression of various cytokines associated with the onset and…
- Trial name
- NCT05018533
- Testing
- TAKC-02
- Where
- Japan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- TAK-Circulator Co.
Healthy Volunteers
Safety and Pharmacokinetic Study of OMT-28 in Healthy Subjects
The aim of this first-in-human study is to assess the safety, tolerability, PK and exploratory pharmacodynamics (PD) of single and multiple oral ascending doses of OMT-28 in healthy male subjects to support further clinical…
- Trial name
- NCT03078738
- Testing
- OMT-28
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Omeicos Therapeutics GmbH
Renal Impairment
A Study to Assess the Pharmacokinetics (Uptake of Drugs by the Body), Safety and Tolerability of AZD4831 in Participants With Severe Renal Impairment and Healthy Volunteers
This is a study to compare AZD4831 pharmacokinetic (PK) parameters between participants with severe renal impairment and matched healthy volunteers following a single dose administration.
- Trial name
- NCT04949438
- Testing
- AZD4831
- Where
- Bulgaria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
BIBW 2992 Administered as Tablet (Final Formulation) Compared to BIBW 2992 Drinking Solution and BIBW 2992 Tablet (Trial Formulation II) in Healthy Male Volunteers
The primary objective of the study was to investigate the relative bioavailability and pharmacokinetics of 20 mg BIBW 2992 administered as film-coated immediate release tablet (final formulation, i.e.
- Trial name
- NCT02171715
- Testing
- BIBW 2992 MA2
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pharmacokinetics, Healthy Subjects
Pharmacokinetics Study of Eplerenone Coated Tablets
The purpose of this study is to evaluate the pharmacokinetics profile of the formulation of eplerenone coated tablets in the concentration of 25mg, 50mg and 100mg (2 coated tablets of 50mg) in male and female healthy subjects…
- Conditions
- Pharmacokinetics, Healthy Subjects, Fasting
- Trial name
- NCT02957435
- Testing
- eplerenone
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Healthy Male Subjects
Study of RPT193 in Healthy Adult Male Subjects
Phase 1, open-label, absorption, metabolism, excretion, and mass balance study.
- Trial name
- NCT06087978
- Testing
- 14C RPT193
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Pain
Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model
This is a Phase I, randomised, double-blind, placebo-controlled, 4-way crossover study to investigate the PD effects, safety, tolerability and PK/PD correlation of two single oral dose levels of IP2015 compared to 300 mg…
- Trial name
- NCT05181852
- Testing
- IP2015, dose 1, IP2015, dose 2, Pregabalin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Initiator Pharma
Ischemia
The Effect of Ticagrelor or Clopidogrel on Endothelial Function During Acute and Chronic Treatment
To investigate if treatment with ticagrelor can mitigate the transient loss of endothelium-dependent vasodilatation of the resistance vasculature following a short period of ischemia, compared with clopidogrel at standard…
- Trial name
- NCT02580149
- Testing
- Ticagrelor, Clopidogrel
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Michael Wolzt, Prof. MD
Healthy
Phase I - Pharmacokinetic Comparability Study in Healthy Male Volunteers
Double-blind, single-dose, three-treatment, parallel group design PK comparability study of MYL-1402O solution manufactured for Mylan compared to US and EU marketed Avastin® solution (bevacizumab).
- Trial name
- NCT02469987
- Testing
- MYL-1402O, US marketed Avastin(R), EU marketed Avastin(R)
- Where
- Netherlands
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Mylan Inc.
Rheumatoid Arthritis
Study to Evaluate and Compare Safety and Pharmacokinetics of the HCP1004 and VIMOVO 500/20mg in Healthy Korean Male
The purpose of this study is to Evaluate and Compare Safety and Pharmacokinetics of the HCP1004 and VIMOVO 500/20mg in Healthy Korean Male
- Trial name
- NCT01688193
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Diabetes, Hyperlipidemia
Investigate the Effect of Food on the Pharmacokinetics of JLP-1310 in Healthy Male Volunteers
A randomized, open-label, single dose, crossover study to investigate the effect of food on the pharmacokinetics of JLP-1310 in healthy male volunteers.
- Trial name
- NCT02449187
- Testing
- JLP-1310, Fasted followed by fed, JLP-1310, Fed followed by fasted
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Metabolic Detoxication, Phase I
Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition
The purpose of this study is to assess how the pharmacokinetic profiles of each drug of a cocktail of six approved drugs (so-called "Basel cocktail") change when the cytochrome P450 system is inhibited or induced.
- Trial name
- NCT01386593
- Testing
- Basel cocktail+(Fluconazole, Ciprofloxacin, Paroxetine), "Basel" Cocktail, Basel cocktail + Rifampicin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Premature Ejaculation
FTIH Study With GSK958108
This study is the first administration of GSK958108 to man. The study will evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK958108 and evaluate the effect of food on GSK958108 pharmacokinetics
- Trial name
- NCT00664365
- Testing
- GSK958108
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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