Clinical trials: Healthy Older Adults
Cognition
Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory…
- Trial name
- NCT06555484
- Testing
- Cross Over Assignment Supplemental Oxygen and Supplemental Air
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inogen Inc.
COVID-19
Phase I Trial of a Recombinant COVID-19 Vaccine (CHO Cell)
This is a phase I, randomized, placebo-controlled, double-blind study, to evaluate safety and immunogenicity of a recombinant SARS-CoV-2 vaccine (CHO cell) in Chinese healthy population aged 18 years and older.
- Trial name
- NCT04636333
- Testing
- Two doses of middle-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14, Three doses of middle-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14, 28, Two doses of high-dose recombinant SARS-CoV-2 vaccine (CHO Cell) at the schedule of day 0, 14
- Where
- China
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Fall Prevention in Healthy Aging
The Effects of an Exergame Training on Body and Brain of Older Adults
This study investigates the effects of an exergame training including strength, balance, and cognitive training components on motor functions, cognition and brain structure of older adults.
- Trial name
- Active@Home (NCT03676452)
- Testing
- Active@Home exergame training
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eling DeBruin
Untrained, Healthy
Brock Exercise And Supplement Trials
This study will analyze the effects of Greek yogurt consumption and an 12 week exercise intervention on muscle size, body composition and bone health in untrained, university-aged males.
- Trial name
- BEAST (NCT03196856)
- Testing
- Resistance and Plyometric Exercise, Greek Yogurt (0% Plain)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brock University
Healthy Older Adults
Neural Representations of Memory Transformation (MEM_TRANS)
Investigators overarching goal is to provide evidence for the link between altered spatiotemporal (where and when) neural mechanisms and the extent of changed memory maintenance in healthy older adults and to identify potential…
- Trial name
- NCT06862622
- Testing
- Computer-based visuomotor sequence learning and interference
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Influenza, Swine-origin A/H1N1 Influenza
A Study of Inactivated Swine-Origin A/H1N1 Influenza Vaccines in Healthy European Subjects Aged 3 to 17 Years
The purpose of this study is to generate data on immunogenicity and safety of the monovalent H1N1 vaccine in support of the development and registration.
- Trial name
- NCT00956202
- Testing
- Swine A/H1N1 influenza vaccine (split virion, inactivated), Swine A/H1N1 influenza vaccine (split virion, inactivated + Adjuvant)
- Where
- 15 sites in Finland
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Aging
Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults
Decline in brain health and associated loss of cognitive function in healthy aging decreases quality of life.We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it…
- Trial name
- NCT04276805
- Testing
- Transcutaneous vagal nerve stimulation (tVNS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pneumococcal Vaccines
Safety, Tolerability, and Immunogenicity Study of a 31-Valent Pneumococcal Conjugate Vaccine (VAX-31) in Adults
The objective of the study is to evaluate the safety, tolerability and immunogenicity of a single injection of VAX-31 at 3 dose levels compared to Prevnar 20™ (PCV20) in adults 50 to 64 years of age in Stage 1.
- Trial name
- NCT06151288
- Testing
- 31 valent pneumococcal conjugate vaccine, 20 valent pneumococcal conjugate vaccine
- Where
- 25 sites in United States
- Volunteers
- 1,015 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Exercise Environment and Cognitive Performance in Older Adults
Outdoor vs. Indoor Exercises and Cognitive Functions in Older Adults
This observational, cross-sectional study aims to comparatively investigate the effects of outdoor versus indoor exercise environments on overall cognitive performance and its specific sub-domains (attention, memory, and…
- Trial name
- NCT07728786
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer's Disease
A Study to Evaluate the Pharmacokinetics and Safety of BEY2153 in Healthy Participants
This is a first in human Phase 1 study to evaluate the safety, tolerability and pharmacokinetics with healthy young and elderly adult male volunteers after receiving single and multiple ascending dose of BEY2153.
- Trial name
- NCT04476303
- Testing
- BEY2153
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- BeyondBio Inc.
Encephalitis, Tick-borne
Immunogenicity and Safety Study of a Rapid Immunization Schedule With FSME-IMMUN 0.5 mL in Healthy Adults Aged 16 - 65 Years
The objective of this study is to establish the earliest time point at which vaccines are expected to show seropositive antibody levels after vaccination with FSME-IMMUN 0.5 mL using a rapid immunization schedule (2 vaccinations…
- Trial name
- NCT00161954
- Testing
- Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults
Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the…
- Trial name
- NCT02804841
- Testing
- Cholecalciferol -Vitamin D3
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Pneumococcal Vaccines
Safety, Tolerability, and Immunogenicity Study of a 24-Valent Pneumococcal Conjugate Vaccine (VAX-24) in Adults
The objective of the study is to evaluate the safety and tolerability of a single injection of VAX-24 at 3 dose levels compared to Prevnar 20™ (PCV20) in adults 18 to 49 years of age in Phase 1.
- Trial name
- NCT05266456
- Testing
- 24 valent pneumococcal conjugate vaccine, 20 valent pneumococcal conjugate vaccine
- Where
- 13 sites in United States
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Healthy
A Study To Look At Safety And Blood Concentrations After Multiple Doses Of PF-03382792 In Healthy Elderly Individuals
This study is designed to look at the safety and blood concentrations of PF-03382792 in healthy elderly subjects after taking multiple doses for 14 days.
- Trial name
- NCT01089738
- Testing
- PF-03382792 0.5mg, PF-03382792 1.5 mg, PF-03382792 5 mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Aging
Daily Dose Estimation of Jarlsberg Cheese in Healthy Norwegian Elderly Male and Female
Aim: To estimate OED of Jarlsberg cheese and the stabilized level of serum Osteocalcin in healthy elderly men and women. Study population consists of healthy men at least 65 years old and healthy post-menopausal women.
- Trial name
- HV-ID (NCT05434806)
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meddoc
Health Behavior
Effectiveness of a Brief Internet-delivered Behaviour Change Intervention Among Healthy Middle-aged Adults
Previous studies have demonstrated the need to move beyond the common misconception of midlife as a time of crisis so that further understandings of the midlife as a time of opportunity for the maintenance and improvement of…
- Trial name
- NCT05033184
- Testing
- Brief Action Planning Exercise, Goal Setting Exercise
- Where
- Canada
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Regina
SARS-CoV2, Covid19
A Study on the Safety, Tolerability and Immune Response of SARS-CoV-2 Sclamp (COVID-19) Vaccine in Healthy Adults
This study is being conducted to look at the safety and immune response (how the immune system of the human body reacts) to a vaccine for SARS-CoV-2 (the virus responsible for COVID-19 infection) when administered as an…
- Trial name
- NCT04495933
- Testing
- MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 5mcg, MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 15mcg, MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 45mcg
- Where
- Australia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Pneumococcal 13-valent Conjugate Vaccine
Safety Study of Pneumococcal 13-valent Conjugate Vaccine in Healthy People Aged 2 Months and Older
This study evaluates the safety of Pneumococcal 13-valent Conjugate Vaccine in Healthy People Aged 2 Months and Older.120 Subjects will be equally divided into 4 groups,including 18 years and older,2-5 years old, 2 months old and…
- Trial name
- NCT02544698
- Testing
- One dose of PCV13a vaccine, three doses of PCV13a vaccine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Chaoyang District Centre for Disease Control and Prevention
Elderly Adults, Mild Cognitive Impairment
Agility Training and Its Relations in Elderly Adults With and Without MCI
The following three-part proposal will focus on the effects of agility training as well as the relationship between agility ability and motor and cognitive function, and risk of falls in elderly adults with or without mild…
- Conditions
- Elderly Adults, Mild Cognitive Impairment, Healthy
- Trial name
- NCT05537363
- Testing
- Health education, Multicomponent training, Agility training
- Where
- Taiwan
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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