Clinical trials: Healthy Older Adults
Influenza, Swine-origin A/H1N1 Influenza
A Study of Different Formulations of an Adjuvanted A/H1N1 Pandemic Vaccine in Healthy Adults and the Elderly
The purpose of the study is to evaluate different doses of the Influenza A/H1N1 pandemic vaccine in adults and the elderly. Primary Objectives: To describe the immunogenicity of the candidate vaccines after a single injection.
- Trial name
- NCT00952276
- Testing
- Monovalent Subvirion A/H1N1 influenza vaccine with adjuvant, Monovalent Subvirion A/H1N1 influenza vaccine, Normal saline solution
- Where
- 15 sites in United States
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy Aging, Cognitive Change
A Digital Active Aging Training Program for Older Adults
The proposed project aims to develop and validate a multi-dimensional digital active aging program integrated with resilience to promote the biopsychosocial functions of older adults aged 60, including Chinese older immigrants in…
- Conditions
- Healthy Aging, Cognitive Change, Psychological Stress, Loneliness
- Trial name
- AAT (NCT06270862)
- Testing
- Resilience training, cognitive training, physical exercise
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Sarcopenia, Memory Loss
Effects of Multidomain Training of Health With Aging (Train-Old)
The current study aims to determine the effect of a multidomain intervention (physical fitness, motivational and cognitive training) on body composition, sarcopenia, cardiovascular health, physical fitness, functional capacity…
- Conditions
- Sarcopenia, Memory Loss, Muscular Atrophy, Cardiovascular Diseases
- Trial name
- Train-Old (NCT05481346)
- Testing
- Multidomain training
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Mild Cognitive Impairment, Healthy
Imaging Tau Deposition in the Brain of Elderly Subjects
Cerebral accumulation of tau and beta-amyloid are major factors of Alzheimer's disease pathology. A novel Positron Emission Tomography (PET) tracer (18-F-AV-1451) now offers the ability to study tau protein deposition in vivo in…
- Conditions
- Mild Cognitive Impairment, Healthy, Alzheimer Disease, Neurocognitive Disorders
- Trial name
- Add-Tau (NCT02958670)
- Testing
- 18F-AV-1451 (Tau-PET tracer)
- Where
- Switzerland
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Bone Density
Mediating Role of Myokines in the Dialogue Between Muscle and Bone Tissue in a Population of Healthy Women Aged 20-89 Years
The main hypothesis is that muscle acts on bone tissue via the secretion of myokines (myostatin, follistatin, irisin). This is based on previous results showing that muscle mass in different patient populations with very…
- Trial name
- MyOs (NCT06683222)
- Testing
- Blood sample, Saliva sample, Grip test
- Where
- 2 sites in France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Microcirculation, Endothelial Dysfunction
Short Term Effects of Probiotics in the Human Micro-vascular Physiology
While the beneficial properties of kefir consumption have been thoroughly studied for many years, very little research has been conducted to explore the potential protective properties of kefir consumption to the endothelium in…
- Trial name
- PIMCO-KEFIR (NCT05234645)
- Testing
- Kefir consumption
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Infections, Meningococcal
Study to Evaluate Meningococcal Serogroups A,C,W-135,Y Conjugate Vaccine When Given as 1 Dose to Healthy Subjects Aged 18-25 Years
The purpose of this study is to evaluate the safety, reactogenicity, immunogenicity and persistence up to three years after administration of one dose of the MenACWY conjugate vaccine when given to young adults aged 18-25 years.
- Trial name
- NCT00196950
- Testing
- Meningococcal (vaccine)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cognitive Change
The Cognitive Effects of 6 Weeks Administration With a Probiotic
The purpose of this study is to investigate the cognitive and mood effects of a probiotic dietary supplement when taken daily for 42 days in healthy older adults aged 65+
- Trial name
- NCT03601559
- Testing
- Lactobacillus paracasei Lpc-37
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Back Pain
Heat Wrap Device Safety With Age and Body Fat
This study is designed to compare the safety, as measured by skin findings and adverse events, of two different heat devices in elderly, overweight, and elderly and overweight subjects.
- Trial name
- NCT01355653
- Testing
- thermal therapy, ThermaCare heatwrap
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Middle-aged Subjects, Obesity & Overweight
Stearic Acid and Endothelial Function
The goal of this clinical trial is to evaluate the postprandial and long-term effects of dietary stearic acid on vascular function in overweight or obese adult males and females aged 40-70 years.
- Trial name
- NCT07831603
- Testing
- High Palmitic Acid Diet, Stearic Acid Test Meal, Oleic Acid Test Meal
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy Volunteers
Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children
The purpose of this study is to assess the cellular immune responses following 2 doses given 3 months apart of tetravalent dengue vaccine candidate (TDV) in 4 to 16 years' healthy participants.
- Trial name
- NCT02948829
- Testing
- TDV
- Where
- 2 sites in Panama, Philippines
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Takeda
Elderly Men
Determination of the UL of Leucine in Healthy Elderly Men
Amino acid are the building blocks of the body's protein. Some amino acids, including leucine, cannot be made in the body and must be obtained from diet, these are called essential.
- Trial name
- NCT02095080
- Testing
- Leucine intake
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Healthy Aging
Designing Communities to Support Healthy Living in Aging Residents
The Housing for Health team is making evidence-based recommendations to the developer and design team of an upcoming congregate-living development to support the healthy living of older adults who will be moving into the new…
- Trial name
- NCT05031273
- Testing
- Residents moving into a congregate-living development with more features that support healthy living
- Where
- Canada
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy
Safety, Tolerability, and Pharmacokinetics of Multiple Rising Doses of BI 425809 Tablets for 12 Days to Young and Elderly Healthy Male and Female Volunteers and Comparison of Pharmacokinetics of a Single Oral Dose of BI 425809 (Morning Versus Evening)
The aim of the study is to investigate the safety, tolerability, and pharmacokinetics of multiple rising doses of BI 425809 tablets given orally once daily for 12 days to young and elderly healthy male and female volunteers and…
- Trial name
- NCT02337283
- Testing
- BI 425809
- Where
- Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Japanese Adults Aged >= 50 Years
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of the 13-valent pneumococcal conjugate (13vPnC) vaccine in healthy Japanese adults aged >= 50 years.
- Trial name
- NCT00562354
- Testing
- 13vPnC
- Where
- 2 sites in Japan
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Pfizer
COVID-19
Booster Study of COVID-19 Protein Subunit Recombinant Vaccine
Observer-blind, randomized, active-controlled prospective intervention study of Immunogenicity \& Safety of SARS-Cov-2 Protein Subunit Recombinant Vaccine (Bio Farma) as a Booster Dose Against COVID-19 in Adults 18 Years of Age…
- Trial name
- NCT05525208
- Testing
- SARS-CoV-2 subunit protein recombinant vaccine, Active Comparator
- Where
- 2 sites in Indonesia
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Seniors
Opti Gait Wearable Gait Tracker
The purpose of this observational study is to test a shoe mounted gait monitoring device that was refined with the input of older adults and assess the efficacy of the refinements through a series of tests that involve walking…
- Trial name
- NCT07158580
- Testing
- Gait Tracker
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Meningitis, Meningococcal
Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Volunteers Aged From 3 to 5 Months
The purpose of this study is to evaluate the immunogenicity and safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in healthy volunteers aged from 3 to 5 months.
- Trial name
- NCT05252715
- Testing
- Meningococcal ACYW135 Polysaccharide Conjugate Vaccine, Meningococcal A and C Polysaccharide Conjugate Vaccine
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
COVID-19
Phase I Clinical Trial of Recombinant SARS-CoV-2 Spike Protein Vaccine (CHO Cell) for the Prevention of COVID-19
The purpose of this double-blind, randomized, controlled study is to assess safety, reactogenicity, and preliminary immunogenicity of 202-CoV at multiple dose levels, administered as 2 injections (i.m) at 28 days apart in adult…
- Trial name
- NCT04982068
- Testing
- 202-CoV low adjuvant dose, 202-CoV low antigen dose, 202-CoV standard dose
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shanghai Zerun Biotechnology Co.,Ltd
Healthy
A Study in Healthy Men and Women Who Are Either Between 18 - 45 Years or Between 65 - 80 Years to Test How Different Doses of BI 474121 Are Tolerated
The main objectives of this trial are to investigate safety and tolerability of BI 474121 in healthy male and female young and elderly subjects following oral administration of multiple rising doses per day over 14 days.
- Trial name
- NCT04537897
- Testing
- BI 474121, Midazolam
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
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