Clinical trials: Healthy Participants, open to volunteers
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy
Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Background: Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat.
- Trial name
- NCT06120244
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cerebral Palsy Children, Healthy Adults
Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy
The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to…
- Trial name
- CP (NCT06811545)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy Volunteers, Attentional Capture
Attentional Capture by Real-life Episodic Information
Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral…
- Trial name
- EPICAPTURE (NCT06934902)
- Testing
- Old vs new objects" encoding phase and fMRI, " incongruent vs. congruent contexts " encoding phase and fMRI
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Alzheimer s Disease, Mild Cognitive Impairment
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Background: About 5 million adults in the United States have age-related brain disorders. These include Alzheimer disease (AD), mild cognitive impairment (MCI), and other dementias.
- Conditions
- Alzheimer s Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT07169630
- Testing
- 18F-PF974, 18F-florbetaben
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Healthy Adult
Modulation of Appetite Signaling Through Enterohormone Stimulation by DNF-10
This is a pilot, proof-of-concept, exploratory, randomized, double-blind, placebo-controlled crossover study. The study will be conducted in 50 healthy volunteers with a body mass index (BMI) between 18.5 and 29.9 kg/m².
- Trial name
- DNF10-APET (NCT07621393)
- Testing
- DNF-10: 500 mg/day
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fytexia
Healthy Subjects (HS), Exercise
Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during…
- Conditions
- Healthy Subjects (HS), Exercise, Hypoxia
- Trial name
- ExHyp (NCT07671638)
- Testing
- Exercise and hypoxia
- Where
- France
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Volunteers
Survey to Determine Incarcerated Persons' Views on Surrogate Decision Making
Background: About 180,000 of the people in US prisons are over 55 years old. Aging people often cannot make medical decisions on their own.
- Trial name
- NCT07751731
- Testing
- Survey
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Volunteers
A Study to Test a Single Dose of a New Tablet Formulation of TRTL-729
This study assesses the safety, tolerability, and pharmacokinetics (PK) of the tablet formulation of TRTL-729 in healthy adults.
- Trial name
- NCT07811063
- Testing
- TRTL-729
- Where
- New Zealand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tortugas Neuroscience, Inc.
Healthy Adult Participants
A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395
This study will enroll healthy participants to evaluate whether BGB-43395 interacts with other drugs, including midazolam, celecoxib, dabigatran, and rosuvastatin.
- Trial name
- NCT07820891
- Testing
- BGB-43395, Midazolam, Celecoxib
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Renal Impairment, Healthy Volunteers
Study to Assess the Plasma Concentration of Rilzabrutinib Given as a Tablet to Adult Participants With Severe Renal Impairment Compared to Matched Participants With Normal Renal Function
The purpose of this Phase 1, open-label, 2-arm study is to assess the effect of severe RI on PK, safety, and tolerability of rilzabrutinib compared with normal renal function, in male and female participants aged from 18 to 75…
- Trial name
- NCT07853131
- Testing
- rilzabrutinib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy
First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers
Background: PDE4D is a protein found in the brain. It helps control chemical signals that affect mood, memory, and thinking. Problems with PDE4D may play a role in depression and Alzheimer's disease.
- Trial name
- NCT07853781
- Testing
- [11C]JMJ-129-d2
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2
In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder, Healthy Adult
- Trial name
- CNTRACS 2 (NCT07875790)
- Testing
- Motion Perception Task, Sine Wave Speech Task, Volatility Task
- Where
- 5 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Volunteers
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants
This is a first-in-human study of NH302 injection in healthy participants. The study will test single intravenous doses of NH302 to evaluate its safety and tolerability, how the body processes NH302, and its effects on selected…
- Trial name
- NCT07892469
- Testing
- NH302 injection
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Digestive Symptoms, Gastrointestinal Symptoms
A Study of Single and Combination Lipase Dietary Supplements to Increase Fatty Acid Absorption in Generally Health Adults
This study aims to investigate the effect of two digestive enzyme dietary supplements, THRIVE4U™ TG Lipase and THRIVE4U™ Spectrum Lipases in supporting the breakdown of fat after a meal.
- Conditions
- Digestive Symptoms, Gastrointestinal Symptoms, Healthy, Impaired Pancreatic Function
- Trial name
- NCT07893288
- Testing
- THRIVE4U™ TG Lipase, THRIVE4U™ Spectrum Lipases
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danisco
IBS, Ulcerative Colitis, Active
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
Aim: More insight in pathogenesis of IBS and IBD. Samples are collected in context of an European research project.
- Conditions
- IBS, Ulcerative Colitis, Active, Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms), Healthy Controls
- Trial name
- NCT02421705
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 99,999,999 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Stroke, Healthy
WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity
This study is to develop, test, and optimize a soft hip wearable robot for individuals with stroke, Parkinson's, multiple sclerosis, or older adults with no neurologic deficits.
- Trial name
- NCT07061691
- Testing
- WIM Robotic Exoskeleton
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Vestibular Schwannoma, Unilateral Vestibular Deficit
Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma
The goal of this clinical trial is to visualize the possible activation of vestibular centers in the brain using in patiens with unilateral vestibular damage, specifically in patients after vestibular schwannoma surgery.
- Conditions
- Vestibular Schwannoma, Unilateral Vestibular Deficit, Healthy
- Trial name
- NCT07130851
- Testing
- vestibular schwannoma resection
- Where
- Czechia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marketa Bonaventurova