Clinical trials: Healthy Patients
Fragile X Syndrome, Healthy Volunteers
Protein Synthesis in the Brain of Patients With Fragile X Syndrome
Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important biochemical processes underlying adaptive…
- Trial name
- NCT00362843
- Testing
- [15-O]water
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimers Disease
Evaluation of [123I] MNI-187 and SPECT in Patients With Alzheimers Disease in Comparison to Healthy Subjects
The underlying goal of this study is to assess 123-I MNI-187 SPECT imaging as a tool to detect ß-amyloid deposition in the brain of AD research participants and age- and gender-matched healthy subjects.
- Trial name
- NCT00456417
- Testing
- 123-I MNI-187 Injection and Imaging Procedures
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Diabetes Mellitus, Hypertension
Correlation of Albuminuria With Arterial Stiffness
The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.
- Conditions
- Diabetes Mellitus, Hypertension, Albuminuria, Vascular Stiffness
- Trial name
- NCT01041599
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Healthy
FCM Analysis GR in Steroid-Treatment Patients
Monitoring the GR with a GR-MoAb and FITC-Dex probes by FCM would be useful and convenient in determination GR before the steroid treatment in clinical, especially in steroid resistant states, in order to design more efficient…
- Trial name
- NCT00600652
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
IPF, Sarcoidosis
Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
Nasal, tracheal and bronchial sampling of MLF in patients with idiopathic pulmonary fibrosis(IPF), sarcoidosis, tuberculosis(TB), asthma and COPD. Similar sampling from healthy controls for comparative data.
- Conditions
- IPF, Sarcoidosis, Tuberculosis, Asthma
- Trial name
- RESPI-SAM (NCT02807025)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Atherosclerosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis
Inflammation in the vascular wall is important in atherosclerosis and the blockage of the artery. The peripheral benzodiazepine receptor is involved in inflammation and in this protocol we will attempt to take pictures, using PET…
- Trial name
- NCT00547976
- Testing
- [C-11]PBR28
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Patient Study
A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RG1662 in Healthy Subjects
The study is being conducted to investigate the effect of itraconazole treatment in the pharmacokinetics of RG1662. It is also to evaluate the exposure of RG1662 vs.
- Trial name
- NCT02470832
- Testing
- RG1662, itraconazole
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Chronic Spontaneous Urticaria, Cholinergic Urticaria
Study of Mechanism of Action of Ligelizumab (QGE031) in Patients With Chronic Urticaria
The purpose of the study is to investigate the mechanism of action for ligelizumab (QGE031) treatment in patients with chronic urticaria. The study has two parts.
- Conditions
- Chronic Spontaneous Urticaria, Cholinergic Urticaria, Cold Urticaria
- Trial name
- MASTER (NCT04513548)
- Testing
- Ligelizumab
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy
Development and Evaluation of Magnetic Resonance Imaging Acquisition and Analysis Methods
Magnetic resonance imaging (MRI) is a diagnostic imaging method with constant progress and improvement in the way the MRI images are obtained. Many of these advances involve changes to MRI software and hardware.
- Trial name
- NCT02091518
- Testing
- MR Screening Questionnaire, Magnetic Resonance Imaging Acquisition and Analysis
- Where
- United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hypertension
The Effects of Antihypertensive Agents on Central Blood Pressure in Healthy Participants and Participants With Hypertension (MK-0000-166) (COMPLETED)
This study will test the relationship between CBP (central blood pressure) and PBP (peripheral blood pressure) effects after single and multiple doses of Isosorbide mononitrate extended release (ISMN ER) or Amlodipine besylate in…
- Trial name
- NCT01130168
- Testing
- Comparator: Amlodipine, Comparator: ISMN ER
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Asthma, COPD
MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
The purpose of this clinical trial is to demonstrate hyperpolarized xenon (HXe) as a medical imaging drug (agent) for Magnetic Resonance Imaging (MRI) of the human lung ventilation.
- Conditions
- Asthma, COPD, Healthy
- Trial name
- HXe-VENT (NCT01833390)
- Testing
- HXe MRI lung ventilation
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Xemed LLC
type1diabetes, Hunger
Postprandial Gut Hormone Responses in Patients With Type 1 Diabetes Mellitus
The study will compare the postprandial responses to a test meal between subjects with type 1 diabetes and healthy control subjects, in terms of gut hormone levels, meal induced thermogenesis, hunger and satiety perception, as…
- Conditions
- type1diabetes, Hunger, Obesity
- Trial name
- NCT04430946
- Testing
- Standardized test meal
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Stroke, Acute
Exercise and RIC and TCD
The first week after a stroke is a particularly important time, as improving blood flow may limit secondary ischaemic damage to the brain and help reduce the overall burden neurological injury and future disability.
- Trial name
- NCT03968068
- Testing
- Exercise Procedure, Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Psoriasis
A Study of the Safety and How the Body Affects a Drug (CNTO 1959) in Healthy Volunteers and in Patients With Psoriasis
The purpose of this study is to evaluate the safety and how the body affects a drug (CNTO 1959) in healthy volunteers and in patients with psoriasis.
- Trial name
- NCT00925574
- Where
- 8 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centocor, Inc.
Pharmacokinetics, Safety
Study to Compare PK & Safety of Advixa With Humira in Healthy, Adult Subject Followed by Efficacy & Safety Study in RA Patients
Adalimumab is a recombinant monoclonal antibody (IgG1 subclass) against human TNF-α (Tumor Necrosis Factor-alpha). It is an immunosuppressive medication predominantly used to treat rheumatoid arthritis autoimmune disease.
- Conditions
- Pharmacokinetics, Safety, Efficacy, Rheumatoid Arthritis
- Trial name
- ACT (NCT05172817)
- Testing
- Advixa (Adalimumab)
- Where
- Bangladesh
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for Developing Science and Health Initiatives, Bangladesh
Inflammatory Bowel Disease
Healthy Normal Single Ascending Dose and Crohn's Patient Multiple Ascending Dose
Healthy Normal Single Ascending Dose and Crohn's patient Multiple Ascending Dose
- Trial name
- NCT00868660
- Testing
- ZP1848
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Zealand Pharma
Healthy Volunteers, Atopic Dermatitis
A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome
The study is divided in 3 parts, starting with the safety assessment of BPR277 ointment in Healthy volunteers (Part 1). If found to be well tolerated in Part 1, BPR277 ointment will be assessed in two different patients groups to…
- Conditions
- Healthy Volunteers, Atopic Dermatitis, Netherton Syndrome
- Trial name
- 3 (NCT01428297)
- Testing
- BPR277 ointment (controlled application), BPR277 ointment, BPR277
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 1
Positron Emission Tomography (PET) Imaging of Pancreatic Beta-Cell Mass in Healthy and Type 1 Diabetic Patients
Pancreatic Islet beta-cells are responsible for synthesizing and secreting appropriate amounts of insulin to regulate blood glucose levels. One factor in the development of diabetes is the loss of beta-cells.
- Trial name
- NCT00958997
- Testing
- 18F-FP-DTBZ (18F-AV-133), Arginine-hydrochloride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Ulcerative Colitis
Second Line Induction Therapy and Healthy Diet for Patients With Ulcerative Colitis
The purpose of this study is to determine whether a diet intervention (the Fasting Mimicking diet) will help induce clinical and biochemical response to an advanced therapy in patients with ulcerative colitis.
- Trial name
- NCT04505410
- Testing
- A plant based high fiber diet that mimics fasting ("FMD") plus advanced therapy, Advanced therapy only without dietary intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Miami
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