Clinical trials: Healthy Patients
Healthy Volunteers, Optic Ataxia
Sensori-motor and Perceptual Functions of the PPC.
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception.
- Trial name
- PPCfonctions (NCT03286686)
- Testing
- point targets, tactile stimulation, visual images
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Alzheimers Disease
Evaluation of [123I] MNI-187 and SPECT in Patients With Alzheimers Disease in Comparison to Healthy Subjects
The underlying goal of this study is to assess 123-I MNI-187 SPECT imaging as a tool to detect ß-amyloid deposition in the brain of AD research participants and age- and gender-matched healthy subjects.
- Trial name
- NCT00456417
- Testing
- 123-I MNI-187 Injection and Imaging Procedures
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Burns
Evaluation Of Linezolid Pk Profile In Burns Patients
Evaluation of linezolid pk profile in burns patients
- Trial name
- NCT00255996
- Testing
- linezolid
- Where
- 3 sites in France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 1 Diabetes (T1D), Healthy Subjects
Effect of Artificial Sweetener (AFS) on Glucose Metabolism in Patients With Type 1 Diabetes (T1D)
The goal of this randomized crossover study is to test the prediction that consuming carbohydrates will affect insulin release differently depending on whether Non-Nutritive Sweeteners (NNSs) are consumed simultaneously.
- Trial name
- AFS_T1D (NCT06315725)
- Testing
- Sweet taste perception with/without sweet taste blockade
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder)
24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring
The goal of this clinical trial is to learn if a new contact lens device can record patterns in eye pressure for 24 hours in adults with glaucoma and in healthy participants.
- Conditions
- Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Ocular Hypertension, Ocular Hypertension (OH)
- Trial name
- NCT06689696
- Testing
- miLens system
- Where
- 3 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Smartlens, Inc.
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Periodontal Indexes
The Effectiveness of Conventional and Pulsating Toothbrushes on Mentally Disabled Children
Children, especially the mentally disabled, are generally incapable of obtaining an adequate oral hygiene level by manual brushing because of their lack of knowledge about oral hygiene and their limited motor skills.
- Trial name
- NCT06140459
- Testing
- Conventional Toothbrushes, Pulsating Toothbrushes
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Antalya Bilim University
Healthy Subjects, Sickle Cell Disease
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease
The purpose of this study is to assess the safety, tolerability, pharmacokinetic, and pharmacodynamic effects of GBT440 compared with placebo in healthy subjects and subjects with sickle cell disease (SCD).
- Trial name
- NCT02285088
- Testing
- GBT440
- Where
- United Kingdom
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Global Blood Therapeutics
Flatulence
Effect of Diet on Intestinal Gas Production and Evacuation in Healthy Subjects and Flatulent Patients
Background Some patients complain of excessive evacuation, which may become socially disabling (Azpiroz F \& Malagelada J-R, 2005).
- Trial name
- NCT01291446
- Testing
- High flatulogenic diet
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Obesity, Physical Inactivity
Changing Healthy Outcomes In Clinic Environments
This study will compare three methods of counseling to determine which is most effective at motivating participants to adopt healthy lifestyle habits.
- Conditions
- Obesity, Physical Inactivity, Diabetes
- Trial name
- CHOICE (NCT00674518)
- Testing
- One on one counseling, Group/team - based health education, PACE physician counseling
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Oregon Health and Science University
Alzheimer Disease, Dementia
Evaluation of Age- and Alzheimer's Disease-Related Memory Disorder
The purpose of this study is to examine how a part of the brain called the hippocampus contributes to memory changes that occur with aging and Alzheimer's disease (AD). Memory problems are the most important early symptoms of AD.
- Conditions
- Alzheimer Disease, Dementia, Memory Disorder, Healthy
- Trial name
- NCT00029120
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Dry Eye Syndrome
Reproducibility of Tearfilm Osmolarity Measurements Using TearLab® in Patients With Dry Eye Syndrome and Healthy Subjects
Dry Eye Syndrome (DES) is a common condition that affects approximately 20% of adults aged 45 and older. Although several clinical tests for the diagnosis and monitoring of DES are available, currently no gold standard for the…
- Trial name
- NCT01744457
- Testing
- Measurement of tear film osmolarity with the TearLab® instrument, Schirmer I test, Tear break up time
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Psoriasis
A Clinical Study of ICP-488 in Healthy Subjects and Patients With Psoriasis
This is a Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Single and Multiple AscendingDose Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ICP-488 in Healthy Subjects…
- Trial name
- NCT05451199
- Testing
- ICP-488
- Where
- 7 sites in China
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Schizophrenia
Glutamate, Learning, and Working Memory
Impairments in plasticity and working memory in schizophrenia have been hypothesized to reflect dysfunction at the N-methyl-D-aspartate glutamate receptor (NMDAR).
- Trial name
- NCT02769936
- Testing
- D-cycloserine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia, Normal Physiology
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Trial name
- NCT00004571
- Where
- United States
- Volunteers
- 3,273 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Hypercholesterolemia
Safety, Tolerability, PK and PD of LGT209 in Healthy Volunteers and Patients With Hypercholesterolemia
This study is designed to measure the effects of LGT209 when given intravenously to patients with high cholesterol who are on stable doses of statin medications, and to healthy subjects with elevated cholesterol
- Trial name
- NCT01979601
- Testing
- LGT209
- Where
- 2 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Mood Disorder, Bipolar Disorder
Examination of Brain Serotonin Receptors in Patients With Mood Disorders
The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. This study will also examine how the stress hormone cortisol affects brain function.
- Conditions
- Mood Disorder, Bipolar Disorder, Depression
- Trial name
- NCT00026832
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Subjects, Patient Performing an MRI Examination
Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam
The purpose of this study is to evaluate the optimization of MRI acquisition sequences.
- Trial name
- AIMANT (NCT04645628)
- Testing
- MRI examination
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Surgery
Ankle/Brachial Non-Invasive Blood Pressure Difference During General Anesthesia
Brachial non-invasive blood pressure (NIBP) monitoring is recommended as part of the American Society of Anesthesiology (ASA) basic monitoring package.
- Trial name
- NCT03547401
- Testing
- Ankle Non-invasive Blood pressure measurement, Arm Non-invasive Blood pressure measurement
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Philippe VAN DER LINDEN
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Safety, Tolerability, PK and PD of ADX-038 in Healthy Participants and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
The first-in-human Phase 1/Phase 2a study described herein will evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ADX-038 in both healthy participants (HP) and in patients with paroxysmal…
- Trial name
- PNH (NCT05876312)
- Testing
- ADX-038
- Where
- 4 sites in Australia, United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ADARx Pharmaceuticals, Inc.
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