Clinical trials: Healthy Related
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
MS-ResearchBiomarkerS
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- MS-ReBS (NCT05204459)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Healthy Subjects
The Relationship Between Dietary Habit and Gastroesophageal Flap Valve Abnormality
Gastroesophageal reflux disease (GERD) is commonly seen in Western countries; however, it is gaining prevalence in Asia countries recently.
- Trial name
- NCT01194544
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Colorectal Cancer, Healthy
Computerized Feedback in Colonoscopy
In a cluster-randomized study compare if feedback from two computerized feedback systems doing a colonoscopy (CoPS and CoRS) can improve the adenoma detection rate and decrease patient discomfort.
- Trial name
- NCT04862793
- Testing
- Colonoscopy Progression Score (CoPS), Colonoscopy Retraction Score (CoRS)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Marital Relationships, Family Relations
The Supporting Healthy Marriage Evaluation
The Supporting Healthy Marriage (SHM) evaluation was launched in 2003 to test the effectiveness of a skills-based relationship education program designed to help low- and modest-income married couples strengthen their…
- Conditions
- Marital Relationships, Family Relations, Low-Income Population, Child Behavior
- Trial name
- SHM (NCT02112058)
- Testing
- A Family-Strengthening Program for Low-Income Families
- Where
- 8 sites in United States
- Volunteers
- 6,298 people
- Sponsor
- MDRC
Healthy, Opioid Use Disorder
Multi-System Analysis of Opioid Receptor Binding
This study will enroll up to 60 adults (including 30 females and 30 males) in three cohorts of up to 20 subjects each. In all three groups, [11C]carfentanil whole-body PET imaging will be used to examine the central nervous…
- Trial name
- NCT05528848
- Testing
- Carfentanil, C-11, Naloxone, Loperamide Hydrochloride
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Opioid Use Disorder
Study of the BIOPIN 6 Naltrexone Implant in Healthy Adults
The purpose of this study is to evaluate the safety and blood levels of a medicine, naltrexone, contained within an implant in healthy volunteers age 18 to 65 years.
- Trial name
- NCT06216132
- Testing
- BIOPIN-6 Active Implant with Naltrexone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Akyso Therapeutics, LLC
Cesarean Section Complications, Pregnancy Related
Assessment of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) for Maternal Pre-oxygenation
The main objective of this study is to determine if the use of transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) can reduce by 90 seconds the time between the entry into the operating room of the volunteer…
- Conditions
- Cesarean Section Complications, Pregnancy Related, Anesthesia
- Trial name
- PREOXCE (NCT04814628)
- Testing
- scenario 1 : pre-oxygenation with a face mask held by the anaesthetist, scenario 2: one anaesthetist in charge, face mask held by the patient for pre-oxygenation, scenario 3: one anaesthetist in charge, THRIVE used for pre-oxygenation
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Healthy
Effect of Kinesiotaping on Force Irradiation
The study is assessed the electromyographic activity response of non-dominant biceps brachii muscle during unilateral-dominant concentric, eccentric and isometric biceps brachii muscle contractions under kinesiotaping and…
- Trial name
- NCT03470714
- Testing
- Force Irradiation, Kinesiotaping
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Obsessive-Compulsive Disorder
Characterize The Modulatory Effects Of Dopamine D2/D3 Receptor Agonist And Antagonist Drugs On Compulsive Behaviors
3 groups of subjects (healthy controls, OCD subjects and stimulant-dependent subjects) will receive pramipexole (1.5 mg, single dose), amisulpride (400 mg, single dose) or placebo in a cross-over, double-blind, placebo-controlled…
- Trial name
- NCT00471588
- Testing
- Pramipexole, Amisulpride
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcoholism
Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence
Background: This study is being done to examine the role of a chemical GABA in the brain of alcohol dependent patients. GABA is the chief inhibitory neurotransmitter in the central nervous system.
- Trial name
- NCT01904487
- Testing
- [11C]flumazenil, Tiagabine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Evaluation of Bone Age by Ultrasound Technology
Ultrasound Evaluation of Bone Age in Healthy Children
Skeletal maturity assessment, defined also as bone age (BA), has an important role in pediatrics and pediatric endocrinology, used mainly for evaluating growth and puberty related endocrine disorders.
- Trial name
- NCT01980693
- Testing
- SonicBone ultrasound
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Opioid-Related Disorders, Substance-Related Disorders
Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used…
- Trial name
- NCT00000252
- Testing
- 0% N2O, 10% N2O, 20% N2O
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Mood Disorders, Anxiety Disorders
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National…
- Conditions
- Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder
- Trial name
- NCT00024635
- Where
- United States
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obesity, Childhood Obesity
Families Becoming Healthy Together
The investigators plan to implement a novel limited RED (high-energy-dense) food variety prescription within a 18-month FBT to examine its effect on 18-month body mass index (BMI).
- Trial name
- NCT04027426
- Testing
- FBT, FBT+Variety
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Health, Subjective, Work Related Stress
Evaluation of the CHIME Intervention for Improving Early Head Start/Head Start Educator Well-being
This study will test how well a mindfulness-based intervention called CHIME improves the emotional well-being of educators in Early Head Start and Head Start (EHS/HS) settings.
- Conditions
- Health, Subjective, Work Related Stress, Compassion, Social Skills
- Trial name
- CHIME (NCT05791825)
- Testing
- Cultivating Healthy Intentional Mindful Educators
- Where
- United States
- Volunteers
- 571 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Alcoholism
Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism.
- Trial name
- NCT00612352
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Cognitive Impairment
Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders
The present trial consists of 2 sub-studies that investigate important novel aspects of treatment with erythropoietin (EPO) on cognitive dysfunction in bipolar disorder (BD) and recurrent unipolar depressive disorder (UD)…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Unipolar Depression
- Trial name
- PreTEC-EPO (NCT03315897)
- Testing
- Erythropoietin, Saline
- Where
- Denmark
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Lars Vedel Kessing
Healthy Volunteers
Brain Activity in Time Discrimination and Sensory Input
This study will use repetitive transcranial magnetic stimulation, or rTMS (magnetic stimulation to the brain), to examine how the brain distinguishes between two signals that are spaced very closely in time.
- Trial name
- NCT00726050
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)