Clinical trials: Healthy Subjects, open to volunteers
Eye Diseases, Healthy Volunteers
Adaptive Optics Retinal Imaging
Background: By the time diseases of the retina are detected, serious damage has often already been done. Researchers want to find better ways of viewing the retina. One way called adaptive optics may help detect problems earlier.
- Trial name
- NCT02317328
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Healthy Male Adults, Food Effect in Healthy Volunteers
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
This is a Phase 1, randomized, single-dose, open-label, two-way crossover study to evaluate the effect of food on AJ201, and to evaluate the safety, tolerability, and pharmacokinetics of AJ201 in Japanese and White healthy male…
- Trial name
- NCT07549919
- Testing
- AJ201
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AnnJi Pharmaceutical Co., Ltd.
Cardiac Risk Factors, Healthy
Imaging Techniques in MRI
Background: Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body.
- Conditions
- Cardiac Risk Factors, Healthy, Healthy Volunteers
- Trial name
- NCT01130545
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Tissue, Muscles
Deep Optical Imaging of Tissue (DOIT)
In medical imaging, X-ray-based methods are widely used, which means that patients are exposed to ionizing radiation. In addition, invasive tissue samples often need to be taken with biopsy needles to, for example, safely…
- Conditions
- Healthy Tissue, Muscles, Extremity, Breast
- Trial name
- DOIT (NCT07754500)
- Testing
- Mk1
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy Participants Study, Contact Lens Wear
Assessment of the Relationship of Soft Contact Lens Fit and Power (Fit & Lens pOwer Soft lenSes)
The purpose of this study is to evaluate whether altering the optical power (in dioptres) of a contact lens affects both vision and lens fit.
- Conditions
- Healthy Participants Study, Contact Lens Wear, Contact Lens Fit
- Trial name
- FLOSS (NCT06745375)
- Testing
- contact lens wear
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aston University
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Berberine
In this study, we will evaluate the relative bioavailability of Berberine (BB) from capsules containing Indian Barberry (Berberis aristate DC.) Bark and Root Extract in the blood plasma of healthy subjects after oral…
- Trial name
- NCT04918667
- Testing
- Berberine incorporated in gamma cyclodextrin, Berberine
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Healthy Participants
A Trial of Lu AH69593 in Healthy Participants
This trial will evaluate the effects of itraconazole (Part A) and, carbamazepine (Part B) on Lu AH69593, and the effect of Lu AH69593 on midazolam (Part C) in adult healthy participants.
- Trial name
- NCT07775261
- Testing
- Lu AH69593, Itraconazole, Carbamazepine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Healthy Participants Study
To Evaluate the Effect of Bacillus Subtilis Based Product in Gut Health and Immunomodulatory Effect in Healthy Adults.
The goal of this clinical trial is to Assess Gut Health and Immunomodulatory Effects of Bacillus Subtilis based product in Healthy Adults The main question[s] it aims to answer are to assess the effects of Bacillus Subtilis on…
- Trial name
- NCT07377942
- Testing
- Probiotics (Bacillus Subtilis)
- Where
- India
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bioagile Therapeutics Pvt. Ltd.
Alzheimer Disease, Amyloid
A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease
The purpose of this Master Protocol is to support multiple studies looking at safety and tolerability of different drugs in healthy participants and participants with Alzheimer's disease, and if they remove clumps of protein…
- Conditions
- Alzheimer Disease, Amyloid, Plaque, Amyloid, Healthy Volunteers
- Trial name
- NCT07787169
- Testing
- LY4405094, Florbetapir F18, Florbetaben F 18
- Where
- 19 sites in United States, China and 1 more
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Traumatic Brain Injury
Assessment of Noninvasive Neuromodulation in a Group of Traumatic Brain Injured Patients and Healthy Volunteers
Background: Severe traumatic brain injury, particularly diffuse axonal injury (DAI), often leads to lasting neurological issues.
- Trial name
- NCT07373366
- Testing
- Subjects in the intervention group receive low-frequency radioelectric therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Heat Strain, Healthy Volunteer Study
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers.
- Conditions
- Heat Strain, Healthy Volunteer Study, Kidney Dysfunction
- Trial name
- NCT06983730
- Testing
- Vitamin B3
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy Adult Participants
A Phase 1 Study of KHN707 Tablets in Healthy Participants
This is a single-center, randomized, double-blind, placebo-controlled study . The objective is to evaluate the safety , tolerability and PK profile of KHN707 tablets in Chinese healthy participants.
- Trial name
- NCT07557537
- Testing
- KHN707 tablet
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Uncontrolled Hypertension
SAL0140 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population
The purpose of this study is to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of SAL0140 healthy Chinese population.
- Trial name
- NCT07051603
- Testing
- SAL0140
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Healthy Volunteers (HV), Skin Irritation
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers for Future Surgical Wound Use
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-MELSAFE (NCT07707986)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Healthy Volunteers, Alcohol Use Disorder (AUD)
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Background: Alcohol use disorder (AUD) is a leading cause of disease and death worldwide. New treatments for AUD are needed. Dopamine, a chemical that carries signals between brain cells, is thought to play a role in alcohol…
- Trial name
- NCT06484075
- Testing
- Siemens 3T PRISMA MR Scanner, PET/CT Scanner, Suvorexant
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Healthy Volunteers
A Technical Innovation of Prismatic Adaptation Test in Healthy Subject, in Favour of Autonomy and Independence in Daily Life Following a Brain Injury
Unilateral neglect is a neuropsychological disorder reflected by a disturbance in the spatial exploration and distribution of directed attention affecting the contralateral part of space and body relatively to the brain lesion.
- Trial name
- PRIS'TUEL (NCT03807401)
- Testing
- Prismatic goggles, Virtual reality device
- Where
- France
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
C-Reactive Protein
A Study of Single and Multiple Doses of LY5625573 in Healthy Participants, Including Japanese and Chinese Populations, and Participants With Inflammation (High C-Reactive Protein)
The purpose of this study is to learn if LY5625573 is safe and how well it is tolerated in healthy participants, including Japanese and Chinese participants, and in participants with high levels of a marker for inflammation…
- Trial name
- NCT07867340
- Testing
- LY5625573, Midazolam
- Where
- 3 sites in United States, Singapore
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Vollunteer
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PTT-121
This is a Phase I, single-center, randomized, double-blind, placebo-controlled SAD/MAD study to evaluate safety, tolerability, and PK of Intravenously Administered PTT-121 in healthy Chinese adults.
- Trial name
- NCT07768176
- Testing
- PTT-121
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Pyrotech Therapeutics, Inc.
Healthy Volunteer
A Study to Assess How Intravenous and Subcutaneous Administrations of Risankizumab Moves Through the Body of Healthy Adult Participants
The purpose of this study is to compare how the drug moves through the body following risankizumab subcutaneous (SC) and risankizumab intravenous (IV) doses.
- Trial name
- NCT07466550
- Testing
- Risankizumab
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy Adult Participants
Evaluation of BRC-002 Safety, Tolerability, Pharmacokinetics, and Food Effects in Healthy Participants
This study will evaluate the safety and tolerability of BRC-002, an investigational botanical drug from cannabis, in healthy adults.
- Trial name
- NCT07699120
- Testing
- BRC-002
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Biopharmaceutical Research Company
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