Clinical trials: Healthy Subjects, open to volunteers
Influenza
A Trial of RLX-2508-102 in Healthy Volunteers
The purpose of this study is to assess safety, PK and immunogenicity profile of a single dose and multiple dose of RLX-2508 in healthy participants across different ethnic backgrounds.
- Trial name
- NCT07873671
- Testing
- RLX-2508
- Where
- 3 sites in Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Atridia Pty Ltd.
Healthy Participants
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JZP269 in Healthy Male and Female Participants
This study will characterize the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) of JZP269 in healthy participants.
- Trial name
- NCT07813663
- Testing
- JZP269
- Where
- 2 sites in United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Healthy Participants
Safety, Tolerability, PK, and PD of TGM-148 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) effects of single ascending doses of TGM-148 in healthy adults
- Trial name
- NCT07843368
- Testing
- TGM-148
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tangram Therapeutics Plc
Healthy Participants Study, General Anesthesia
Safety, Pharmacokinetics, and Pharmacodynamics of Continuous KL0011034 Infusion in Healthy Chinese Adults
This Phase 1 study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of continuous intravenous infusion of KL0011034 Injection in healthy Chinese adults.
- Trial name
- NCT07841626
- Testing
- KL0011034 Injection, Propofol Injectable Emulsion
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Healthy Subjects, Hyperlipidemia, Hypertriglyceridemia
First-in-Human Study of ISH0688: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics
ISH0688 is a human IgG1 Fc-FGF21 fusion protein. The objectives of the planned clinical investigation will be to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single- and…
- Trial name
- NCT07505043
- Testing
- ISH0688 for injection
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- SUNHO（China）BioPharmaceutical CO., Ltd.
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Adult Trial Participants
Phase 1 Clinical Study of GenSci155 Injection in Healthy Adults
This is a Phase 1, single-center, randomized, double-blind, placebo-controlled, single and multiple intravenous ascending dose clinical study to evaluate the safety, tolerability, PK, immunogenicity, and biomarker characteristics…
- Trial name
- NCT07638800
- Testing
- GenSci155 Injection
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Healthy Participants
A Study to Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function
The purpose of the study is to look at how the body processes a study medicine called vepdegestrant in participants with loss of liver function relative to people with normal liver function.
- Trial name
- NCT07231991
- Testing
- vepdegestrant
- Where
- 4 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Stroke, Cramp
The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical…
- Conditions
- Stroke, Cramp, Restless Legs Syndrome, Healthy Volunteers
- Trial name
- MnHyperex (NCT05908214)
- Testing
- wide pulse high frequency neuromuscular electrical stimulation training
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Aging, Healthy
Safe-Age Study: A Safety and Tolerability Study of a Nutritional Supplement in Healthy Older Adults
The goal of this clinical trial is to evaluate the safety and tolerability of the nutritional supplement Youniqor in healthy older adults.
- Trial name
- SAFE-AGE (NCT07442097)
- Testing
- Youniqor
- Where
- India
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- YOXLO B.V.
ST-Elevation Myocardial Infarction (STEMI), Heart Failure With Preserved Ejection Fraction (HFpEF)
Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis
An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or…
- Trial name
- PARIS (NCT06956560)
- Testing
- PET/MRI or separate PET/CT and MRI
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Amyotrophic Lateral Sclerosis
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
Researchers will evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered Amisodin in healthy adult subjects through a randomized, double-blind, placebo-controlled Phase 1 study consisting of two parts…
- Trial name
- ALS (NCT07221240)
- Testing
- Amisodin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PRG Science & Technology Co., Ltd.
Healthy Participants, Overweight or Obese Participants
Clinical Trials of IBI3040 in Healthy Participants and Overweight or Obese Participants
Clinical trials of IBI3040 with single-dose administration in healthy participants and multiple-dose administration in overweight or obese participants.
- Trial name
- NCT07765160
- Testing
- SAD: subcutaneous injection in the abdomen, MAD: subcutaneous injection in the abdomen
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Healthy Volunteers, Erythritol
SUVY VerSus SAccharose (SUVISA)
Sugar substitutes are increasingly used to reduce sugar intake. SÜVY is a food ingredient combining erythritol and polydextrose.
- Trial name
- SUVISA (NCT07901491)
- Testing
- SÜVY, Sucrose
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Minerais SAS
Health Adult Subjects
Effect of Different Currents for Transcranial Modulation of the Sensorimotor Corticospinal Pathway in Healthy Subjects
Transcranial modulation of the corticospinal sensorimotor pathway is a promising approach in neuroscientic functions. Among the techniques used, transcranial direct current stimulation (tDCS), transcranial alternating current…
- Trial name
- CURRENT-Flow (NCT07831525)
- Testing
- Transcranial Alternating Current Stimulation, Transcranial Direct Current Stimulation, Transcranial Random Noise Stimulation (tRNS)
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy Volunteers
First-in-Human Single and Multiple Dose of KLA578-1 for Injection
The purpose of this study is to evaluate the safety and tolerability and pharmacokinetics of single and multiple doses of KLA578-1 for injection in healthy volunteers
- Trial name
- NCT07143318
- Testing
- KLA578-1 for injection, Etopcoxib Tablets
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hunan Kelun Pharmaceutical Co., Ltd.
Healthy Participants
Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation
The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol.
- Trial name
- NCT07161518
- Testing
- Low-intensity transcranial ultrasound, Propofol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Participants
Feasibility Study Aiming at Pre-Analytical Standardization of Whole Blood Processing for Liquid Biopsy Applications
The goal of this feasibility study is to evaluate a new sample preparator called See.d. After blood processing the instrument will produce a set of slides and a tube of plasma.
- Trial name
- NCT05942066
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tethis S.p.A.
Hepatic Impairment
Study to Evaluate the Pharmacokinetics (PK) of E7090 (Herein Referred to as Tasurgratinib) and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants
The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of tasurgratinib after a single dose administration.
- Trial name
- NCT04271488
- Testing
- Tasurgratinib
- Where
- 8 sites in Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Depression
Nitrous Oxide and EMOtional Cognition
The goal of this study is to uncover the underlying neuropsychological mechanisms of nitrous oxide, which may be relevant to its reported antidepressant effects.
- Trial name
- NEMO (NCT06557642)
- Testing
- Entonox, Medical Air
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Oxford
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