Clinical trials: Healthy Volunteer, Type 2 Diabetes
Obesity and Overweight
A First-in-human Study of HCR-188 in Overweight or Obese Otherwise Healthy Volunteers Without Type 2 Diabetes
This is a first-in-human study evaluating the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of single and multiple doses of HCR-188 administered as subcutaneous injection(s).
- Trial name
- NCT06845943
- Testing
- HCR-188
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Helicore Biopharma, Inc.
Type 2 Diabetes Mellitus
A Drug Interaction Study Between Simvastatin and GSK376501
This study is a 3-period crossover drug interaction study between GSK376501 and simvastatin in healthy adult subjects. This study will examine if repeat doses of GSK376501 affects the pharmacokinetics of simvastatin and if repeat…
- Trial name
- NCT00605449
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
First-Time-in-Humans Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of SB756050
This study will use single escalating doses of SB756050 to assess safety, pharmacokinetics, and pharmacodynamics in healthy volunteers and in subjects with Type 2 Diabetes Mellitus.
- Trial name
- NCT00607906
- Testing
- SB-756050 immediate release capsule, SB-756050 modified release capsule
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
Study of the Bioequivalence and Food Effects of HRX0701 Tablets in Healthy Subjects
To evaluate the bioequivalence of a single oral dose of HRX0701 tablets and the reference formulations retagliptin phosphate tablets and metformin hydrochloride tablets in healthy subjects in the postprandial state; To evaluate…
- Trial name
- NCT05415644
- Testing
- hrx0701 tablets、Metformin hydrochloride tablets、Retagliptin phosphate tablets, hrx0701 tablets
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia
Bioequivalence Study Of Glucotrol XL 2.5 Mg Tablets
The objective of this study is to determine the bioequivalence of Glipizide GITS (Glucotrol XL) 2.5 mg tablets manufactured at the Brooklyn, New York facility versus tablets manufactured at the facility in Barceloneta, Puerto…
- Trial name
- NCT00550329
- Testing
- Glipizide GITS
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight or Obesity, Type2 Diabetes Mellitus
Phase 1b/2a Study of GSBR-1290 in Adult Overweight or Obese Healthy Subjects and Subjects With Type 2 Diabetes Mellitus
This study will evaluate safety, tolerability, pharmacokinetic (PK) profile, and pharmacodynamic (PD) effects on GSBR-1290 in healthy overweight/obese volunteers (HOV) and Type 2 Diabetes Mellitus on Metformin (T2DM) This study…
- Trial name
- NCT05762471
- Testing
- GSBR-1290
- Where
- 4 sites in United States
- Volunteers
- 142 people
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Diabetes Mellitus, Type 2
Avandamet Bioequivalence Study Brazil - Fed Administration
The study is prospective, open-label, randomized, crossover, with 02 treatments, 02 sequences, and 02 periods. The volunteers received, in each period, the reference or the test formulation after standardized meals.
- Trial name
- NCT01332071
- Testing
- Rosiglitazone Maleate + Metformin 2 miligrams (mg) + 500 mg, Rosiglitazone Maleate + Metformin 4 miligrams (mg) + 1000 mg
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)
This is an active- and placebo-controlled, single-site, four-part trial of MK-1092 in healthy adult participants, in participants with type 1 diabetes mellitus (T1DM), and in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03170544
- Testing
- MK-1092, 4.0 nmol/kg, MK-1092, 8.0 nmol/kg, MK-1092, 16 nmol/kg
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type II
Investigate the Effect of Food on the Pharmacokinetic Characteristics of CKD-395 in Healthy Male Volunteers
This study is A randomized, open-label, single dose, 2-way crossover study to investigate the effect of food on the pharmacokinetic characteristics of CKD-395 in healthy male volunteers.
- Trial name
- NCT02648854
- Testing
- CKD-395 0.5(Lobeglitazone)/1000(Metformin)mg 1T
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Healthy Volunteers, Diabetes Mellitus, Type 2
A Study to Look at How Safe NNC0472-0147 is in Healthy People and in People With Type 2 Diabetes
This study is investigating the safety and tolerability of the new medicine NNC0472-0147, its concentrations in the blood and its effect on blood sugar for the treatment of diabetes.
- Trial name
- NCT04262661
- Testing
- NNC0472-0147, insulin glargine
- Where
- 2 sites in Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Study to Determine the Safety, Tolerability, and Effects of GSK2374697 in Healthy Volunteers
This is a single-blinded, randomized, placebo-controlled, staggered-parallel, escalating dose study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2374697 in healthy volunteers.
- Trial name
- NCT01545570
- Testing
- GSK2376497, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus
The Clinical Trial to Investigate the Pharmacokinetics and Safety/Tolerability of CKD-375
The purpose of this clinical trial is to evaluate the pharmacokinetics and safety/tolerability after oral administration of CKD-375 and D387 in healthy adults.
- Trial name
- NCT03848637
- Testing
- CKD-375, D387
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Healthy Volunteers, Type 2 Diabetes
A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (D) Semaglutide Tablets
In this study two different tablets for oral use of a known investigational medicinal product, called semaglutide, will be tested. One is the current formulation and the other one is a new formulation of semaglutide.
- Trial name
- NCT04097600
- Testing
- Oral semaglutide
- Where
- Germany
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes or Obesity Without Diabetes
Search for Biological Markers of Orosensory Perception of Fatty Acids in Healthy Subjects and Possible Modifications in Patients With Type 2 Diabetes and in Obese Non-diabetic Patients.
Animal studies have shown that stimulation of the lingual lipid-receptor, CD 36, is accompanied by the rapid secretion of hormones in the digestive tract (incretines).
- Trial name
- NCT02028975
- Testing
- Measure the threshold of detection for linoleic acid, Oral stimulation tests, Venous blood samples
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Type 2 Diabetes
A HR20031 BE Study on Healthy Subjects
The purpose of this study is to assess the bioequivalence between HR20031 FDC tablet and co-administration of SHR3824 tablets, SP2086 tablets and metformin XR tablets.
- Trial name
- NCT05682495
- Testing
- ARM A, ARM B, ARM C
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Diabetes Mellitus, Type 2
Omarigliptin & Trelagliptin in Twelve Healthy Egyptian Volunteers
The proposed study will consider the LC-MS/MS quantitative determination of Omarigliptin \& Trelagliptin after administration to twelve Egyptian volunteers.
- Trial name
- NCT03362398
- Testing
- Omarigliptin 25 mg, Trelagliptin 100 mg
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Type 2 Diabetes Mellitus
A Study of ZT002 in Healthy Participants
This study will comprise a randomized, parallel assignment, double blind, placebo controlled, single and multiple ascending dose, safety, tolerability and pharmacokinetic study of ZT002 in healthy participants.
- Trial name
- NCT05491421
- Testing
- ZT002
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- QL Biopharmaceutical Australia Pty Ltd
Diabetes Mellitus, Type 2, Insulin Resistance
Low Dose Fat-Induced Insulin Resistance
The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Insulin Sensitivity
- Trial name
- BCAA (NCT03479671)
- Testing
- Intralipid, 20% Intravenous Emulsion
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 2 Diabetes Mellitus
Study To Investigate The Safety And Metabolism Of GSK376501 In Overweight Subjects
This study represents the second Phase 1 study with GSK376501 and the goal is to further evaluate its safety and tolerability. The way the human body processes GSK376501 will also be determined.
- Trial name
- NCT00495014
- Testing
- GSK376501
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers Type 2 Diabetes
A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men
This study looks at how the new medicine called NNC0480-0389 works in the body of Japanese men when it is given together with semaglutide.
- Trial name
- NCT04878406
- Testing
- NNC0480-0389, Semaglutide
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S