Clinical trials: Healthy Volunteer Subjects
Depression
A Study of Nociceptin/Orphanin FQ Peptide Receptor Occupancy in Healthy Subjects
The purpose of this trial is to conduct an assessment of brain nociceptin/orphanin FQ peptide (NOP) receptor occupancy (RO) in healthy subjects.
- Trial name
- NCT01404091
- Testing
- LY2940094
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- BlackThorn Therapeutics, Inc.
Healthy Volunteers
A Study Comparing The Amounts of Tafamidis In The Blood With Or Without Food
Each subject will be given tafamidis after either a high fat meal or while fasted. After swallowing tafamidis, tafamidis blood concentrations will be measured periodically for one week.
- Trial name
- NCT02406560
- Testing
- tafamidis
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Safety Issues, Pharmacokinetic
Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)
Double-blind, randomised, placebo-controlled phase I trial with single-ascending and multiple-ascending dose to evaluate safety and pharmacokinetics of oral controlled-ileocolonic-release nicotinamide (CICR-NAM) compared to…
- Trial name
- NCT05258474
- Testing
- controlled-ileocolonic-release nicotinamide (SAD/MAD/MD), Immediate-release nicotinamide (SAD)
- Where
- Germany
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Healthy Volunteers
Single Oral Dose of 4 mg Cenerimod in Healthy Japanese and Caucasian Subjects
This study is for research purposes only and is not intended to treat any medical condition. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of cenerimod…
- Trial name
- NCT04052360
- Testing
- Cenerimod
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Healthy Volunteers
Bioequivalence Study of Levetiracetam Tablet and Intravenous Infusion in Healthy Japanese Subjects
The purpose of this study is to investigate the pharmacokinetics(PK) and evaluate the bioequivalence of levetiracetam (LEV) following a single 15-minutes IV infusion of 1500 mg and a single oral dose(tablets) of 1500 mg in…
- Trial name
- NCT01394224
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
COVID-19; and High Infection Risk of SARS-CoV-2
Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects
This is a randomized, double-blind, placebo-controlled, phase I clinical study to evaluate the tolerability, safety, pharmacokinetic profile and immunogenicity of JS016 (anti-SARS-CoV-2 monoclonal antibody) injection in Chinese…
- Trial name
- NCT04441918
- Testing
- JS016 (anti-SARS-CoV-2 monoclonal antibody)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Healthy Subjects
A Pharmacokinetic (PK) Study of Three Types of E0302 Sustained Release (SR) Tablets Compared With E0302 Immediate Release (IR) Tablet Under Fed Conditions in Healthy Participants
To assess the PK and safety after administration of three types of E0302 SR tablets (SR1, SR2, SR3) and E0302 IR tablet.
- Trial name
- NCT03885882
- Testing
- E0302 SR1, E0302 SR3, E0302 SR2
- Where
- New Zealand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Healthy Participants
A Comparative Phase 1 Study to Evaluate the Pharmacokinetic and Safety of QL2302 vs. Tezspire® in Healthy Subjects
This is a randomized, double-blinded, controlled Phase 1 study to compare the pharmacokinetic, safety and immunogenicity of QL2302 versus Tezspire®（Tezepelumab） in healthy subjects after a single dose.
- Trial name
- NCT07327697
- Testing
- QL2302, Tezspire
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Brain Injuries, Traumatic
Safety Study of NNZ-2566 in Healthy Subjects, Following Oral Administration
The purpose of this study is to obtain evidence of safety and determine the pharmacokinetics (PK) of NNZ-2566 in healthy volunteers, when administered orally.
- Trial name
- NCT01420042
- Testing
- NNZ-2566
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neuren Pharmaceuticals Limited
Type 2 Diabetes Mellitus
Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects
This is a phase I, open-label, fixed-sequence study in healthy Chinese subjects, performed at a single study centre. Cohort A will assess the Pharmacokinetic (PK) profile of rongliflozin when administered alone and the…
- Trial name
- NCT05497674
- Testing
- Rongliflozin, Rifampin, Probenecid
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Osteonecrosis of the Femoral Head
RAB001（LLP2A-Ale） in Healthy Subjects
This trial is a single center, randomized, double-blind, placebo-controlled dose escalation study aimed at examining the safety, tolerability, and pharmacokinetics/pharmacodynamics of single and multiple injections of RAB001 in…
- Trial name
- LLP2A-Ale (NCT07545018)
- Testing
- RAB001 400 μg/kg group, RAB001 750 μg/kg group, Normal saline
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Melanoma
Sentinel Lymph Node Mapping Using Magtrace and MRI in Healthy Subjects for Potential Use in Melanoma Patients
Sentinel lymph node biopsy (SLNB) is crucial in the management of malignant melanoma treatment and is currently performed by pre-operatively inject a colloid nanomaterial labeled with Technetium (99mTc) as radioactive tracer.
- Trial name
- TRACIE (NCT05054062)
- Testing
- Sentinel node mapping using MRI
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Healthy
Study Evaluating The Co-Administration Of Moxidectin And Midazolam In Healthy Subjects
The purpose of this study is to evaluate the effect of single doses of midazolam on the plasma concentration of a single dose of moxidectin in healthy young adult subjects, and to assess the safety of co-administration of…
- Trial name
- NCT00856362
- Testing
- Moxidectin, Midazolam
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Uninfected Healthy Adult Subjects
REF-VALUE Study: Establishment of Reference Values for Biomarkers in Healthy Adults
Circulating biomarkers play a central role in translational research and precision medicine, particularly for the diagnosis, prognostic, monitoring of inflammatory or infectious diseases and patient stratification.
- Trial name
- REF-VALUE Stud (NCT07666191)
- Testing
- Biological Sampling
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Diabetes
Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism on Healthy Subjects
It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose.
- Trial name
- NCT02487680
- Testing
- Amino Acids and chromium-picolinate containing drink
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Covid19-associated ARDS, Covid19
A First-in-Human Study of AV-001 in Healthy Subjects
Phase 1 randomized, double-blind, placebo-controlled single ascending dose (SAD) and multiple ascending dose (MAD) first-in-human study in healthy subjects.
- Conditions
- Covid19-associated ARDS, Covid19, ARDS
- Trial name
- NCT04737486
- Testing
- AV-001
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vasomune Therapeutics, Inc.
Healthy Volunteers
Bioequivalence Study Comparing Linezolid 600 Mg Oral Suspension With 600 Mg Tablet In Chinese Healthy Male Subjects
The purpose of this study is to estimate the bioequivalence comparing Linezolid 600 MG Oral Suspension with 600 MG tablet in Chinese healthy male subjects. This study data will be used to support Linezolid OS NDA in China.
- Trial name
- NCT01055769
- Testing
- Linezolid
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Subjects
Study of a Single Dose of PRS-060 Administered by Oral Inhalation or IV Infusion in Healthy Subjects
A Dose Escalating Study of PRS-060 Administered by Oral Inhalation or IV Infusion in Healthy Subjects
- Trial name
- NCT03384290
- Testing
- PRS-060
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Pieris Australia Pty Ltd
Stroke, Neurologic Disorder
Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
Transcranial static magnetic field stimulation (tSMS) is a novel brain stimulation technique that has been shown to be safe and effective in modifying biological parameters when applied to the cerebral cortex.
- Conditions
- Stroke, Neurologic Disorder, Manual Dexterity
- Trial name
- NCT05260190
- Testing
- tSMS
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Pain
The Role of Sympatho-vagal Balance on Different Limbs of Pain Perception in Healthy Subjects
objectives 1. To study the sympatho-vagal balance effect on different limbs of pain perception. 2. To determine whether it is the hypertension by itself or the baroreflex activation due to blood pressure rise that is responsible…
- Trial name
- NCT01621620
- Testing
- Yohimbine
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
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