Clinical trials: Healthy Volunteer Subjects
Healthy Volunteer Study
Pharmacokinetics of Fixed-Dose Combination Tablet of Bemnifosbuvir and Ruzasvir
This study will assess comparative bioavailability and effect of food on a prototype fixed-dose combination (FDC) of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in healthy subjects
- Trial name
- NCT06204679
- Testing
- Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fasting conditions, Bemnifosbuvir (BEM)/Ruzasvir (RZR) FDC under fed conditions, Bemnifosbuvir (BEM) and Ruzasvir (RZR) as reference formulation under fasting conditions
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Healthy Volunteers
Single-dose, Pharmacokinetics of AMG 853 in Healthy Adult Subjects
To determine the bioavailability and the effect of food on the pharmacokinetics under fasted and fed conditions
- Trial name
- NCT01124279
- Testing
- AMG 853
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Amgen
Healthy Volunteers
Single and Multiple Ascending Dose Study to Assess the Safety, Tolerability and PK of ONO-2910 in Japanese and Caucasian Subjects
To investigate safety, tolerability and pharmacokinetics in Japanese and Caucasian subjects when ONO-2910 is administered as single and multiple doses orally.
- Trial name
- NCT04504760
- Testing
- ONO-2910
- Where
- Japan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Dyslipidemia
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 in Healthy Subjects
This study will assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of AZD0780 following single and multiple dose administration to healthy subjects with or without elevated Low-Density…
- Trial name
- NCT05384262
- Testing
- AZD0780, Rosuvastatin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Colorectal Neoplasms
The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects
Fats and oils play important roles in maintaining human nutrition and health through providing energy, essential fatty acids, and acting as modulators of many biological processes (signal transduction, immunity and inflammation).
- Trial name
- NCT02599103
- Testing
- Fat-free milkshake, Olive oil, Soybean oil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Academia Sinica, Taiwan
Healthy Volunteers
Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-9545 Following a Single Oral Dose (Part 1) and to Evaluate the Absolute and Relative Bioavailability of Oral Capsule Formulations of GDC-9545 (Part 2) in Healthy Female Subjects of Non-Childbearing Potential
This is an open-label, single-center, two part study in healthy female subjects of non-childbearing potential to investigate the absorption, metabolism, and excretion of [14C]-GDC-9545 (Part 1), the absolute bioavailability of…
- Trial name
- NCT04680273
- Testing
- [14C]-GDC-9545, GDC-9545 Solution for Infusion, GDC-9545/F12 Capsule
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Renal Impairment
Pharmacokinetic Properties of Nalmefene in Subjects With Renal Impairment and in Healthy Subjects
To investigate if renal impairment will have an impact on the pharmacokinetics of nalmefene
- Trial name
- NCT01934166
- Testing
- Nalmefene 18 mg
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Schizophrenia
Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects
This is an observational, non-interventional study that will recruit Healthy Volunteers (HV) and subjects with clinically confirmed Schizophrenia (SZ).
- Trial name
- NCT04025502
- Testing
- Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System
- Where
- 4 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- ERP Biomarker Qualification Consortium
Healthy
Study Comparing Two Different Tablet Formulations Of Bosutinib Under Fed Conditions
Study comparing 2 formulations of bosutinib in healthy subjects.
- Trial name
- NCT01080365
- Testing
- SKI-606 (Bosutinib)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy
Bioavailability Study of Prodrug of GLPG0187 in Healthy Volunteers
The purpose of this study is to evaluate the amount of GLPG0187 present in the blood (pharmacokinetics) after a single oral dose of the prodrug of GLPG0187 given to healthy subjects.
- Trial name
- NCT01580644
- Testing
- GLPG0187 prodrug
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Vascular System Injuries
Natural Antioxidant Ice-cream, Oxidative Stress and Vascular Function
Formation of reactive oxygen species (ROS) contributes to pathogenesis and progression of several diseases. Polyphenols, have been shown to be beneficial against ROS.
- Trial name
- NCT02685163
- Testing
- Antioxidant ice-cream, Control Ice-cream
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy
PK, Safety & Tolerability of CyCol® Versus Sandimmune® in Healthy Subjects
The aim of this Phase I, single centre, multi stage study is to evaluate the safety, tolerability, pharmacokinetics and relative colonic mucosal concentrations of cyclosporine capsules (CyCol®) compared to intravenous…
- Trial name
- CYC102 (NCT02130414)
- Testing
- Sandimmun® IV, CyCol® capsules
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sigmoid Pharma
Bioavailability, B-cell Lymphoid Cancer
A Study to Evaluate Relative Bioavailability, Proton Pump Inhibitor (PPI) (Rabeprazole) Effect, Food Effect and Particle Size Effect of New Acalabrutinib Tablet in Healthy Subjects
This study will be a 2-part, open-label, single-center relative bioavailability, PPI effect, food-effect and particle size effect randomized crossover study of acalabrutinib tablets in healthy subjects (males or females).
- Trial name
- NCT04488016
- Testing
- Treatment A- Part 1, Treatment B- Part 1, Treatment C - Part 1
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers, Bioavailability
Bioavailability and Effect of Food on DSM265 Granules in Healthy Adult Subjects
This is a single-dose, fasting and non-fasting, open-label, randomized, three-regimen, parallel group study in 42 subjects
- Trial name
- NCT02750384
- Testing
- DSM265 50% SDD granules, DSM265 25% SDD powder for suspension
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Healthy
Safety and Tolerability of GBR 900 in a Single Ascending Dose Study in Healthy Subjects
A Single Dose Study of GBR 900 in Healthy Volunteers.
- Trial name
- NCT02235727
- Testing
- GBR 900
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Anal Resting Pressure
An Open Label Study to Examine the Effect of Coated Nifedipine Suppositories on Anal Pressure in Healthy Subjects
This is an open label, dose-finding study. Approximately 8 healthy subjects will be participating in this study. Within one week after the screening visit, subjects who meet all inclusion criteria and none of the exclusion…
- Trial name
- NCT00816205
- Testing
- Coated Nifedipine Suppositories
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- RDD Pharma Ltd
Smoking
Intervention With Black Currant Seed Press Residues in Healthy Subjects
The study was performed to investigate the effects of the consumption of black currant seed press residues, which were baked into bread.
- Trial name
- NCT00662766
- Testing
- black currant seed press residue, Bread without black currant seed press residues, Baseline data
- Volunteers
- 36 people
- Sponsor
- University of Jena
Healthy
Ursodiol 500 mg Tablets Under Fed Conditions
The objective of this study was to evaluate the comparative bioavailability between Ursodiol 500 mg Tablets (test) and Urso Forte™ 500 mg Tablets (reference)after a single-dose in healthy subjects under fed conditions.
- Trial name
- NCT00909753
- Testing
- Ursodiol, Urso Forte™
- Where
- Canada
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Healthy Subjects, Pharmacokinetics
Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects
The purpose of this study is to evaluate the effect of steady state solifenacin and mirabegron on the pharmacokinetics of co-administered steady state digoxin.
- Conditions
- Healthy Subjects, Pharmacokinetics, Drug-Drug Interaction (DDI)
- Trial name
- NCT02127034
- Testing
- Mirabegron, Solifenacin, Digoxin
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Gastroparesis, Diabetes Complications
To Study the EGG Abnormalities in Healthy Subjects and in Patients With Idiopathic and Diabetic Gastroparesis.
Electrogastrogram (EGG) is a non-invasive method for recording myoelectric activities by placing electrodes on the abdomen surface.
- Conditions
- Gastroparesis, Diabetes Complications, Idiopathic Gastric Motility Disorder, Dyspepsia
- Trial name
- NCT05624034
- Testing
- Electrogastrography
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
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