Clinical trials: Healthy Volunteer Subjects
Healthy
First-in-human Study of Safety, Pharmacokinetics and Pharmacodynamics of Various Doses of BCD-089 in Healthy Subjects
This is an open label, phase 1, "3+3" dose escalating study of tolerability, safety, pharmacokinetics, pharmacodynamics and immunogenicity of a single subcutaneous injection of the novel monoclonal antibody against the…
- Trial name
- NCT03103438
- Testing
- BCD-089
- Where
- Russia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Biocad
Obesity, Overweight
A Multiple Dose Study Of PF-04620110 In Overweight And Obese, Otherwise Healthy Volunteers
PF-04620110 is a novel compound proposed for the treatment of Type 2 diabetes mellitus. The primary purpose of this trial is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics, of multiple oral doses…
- Conditions
- Obesity, Overweight, Healthy
- Trial name
- NCT00959426
- Testing
- PF-04620110
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
A Study to Assess the Effect of Food Intake and Drug-drug Interactions of E7090 When Co-administered With Rabeprazole or Rifampin in Healthy Participants
This study will have three parts: Part A, Part B, and Part C. The primary purpose of Part A is to evaluate the effect of food on the rate and extent of E7090 absorption following single oral doses of E7090 in healthy…
- Trial name
- NCT04565574
- Testing
- E7090, Rabeprazole 20 mg, Rifampin 600 mg
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Healthy
Phase 1 Study in Healthy Subjects to Evaluate the Effect of Rifampin on the Pharmacokinetics of IPI-145
To evaluate the effect of rifampin, a cytochrome P450 3A (CYP3A) inducer, on the pharmacokinetics (PK) of IPI-145; to assess the safety and tolerability of IPI-145 when administered with rifampin in healthy subjects
- Trial name
- DDI (NCT01947777)
- Testing
- IPI-145, Rifampin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- SecuraBio
Healthy
A Study to Assess the Relative Bioavailability of 4 Formulations of Fentanyl Transdermal System Compared Against DUROGESIC Fentanyl Transdermal Patch After Single Application in Healthy Volunteers
The purpose of this study is to evaluate the pharmacokinetics and relative bioavailability of 4 new formulations of fentanyl transdermal patch in healthy participants after a single application for 72 hours.
- Trial name
- NCT01717157
- Testing
- Treatment A: DUROGESIC (8.4 mg fentanyl), Treatment B: Transdermal System-Concept 1 (6.2 mg fentanyl), Treatment C: Transdermal System-Concept 2 (6.2 mg fentanyl)
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Leprosy
Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers
The purpose of this study is to compare the safety, tolerability, and immunogenicity in healthy adult subjects of an investigational vaccine being developed for the prevention of leprosy.
- Trial name
- NCT03302897
- Testing
- LEP-F1 + GLA-SE
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Access to Advanced Health Institute (AAHI)
Healthy Adult Subjects
Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers
The purpose of this study is to determine the safety and pharmacokinetics following a single oral dose of MBX-400.
- Trial name
- NCT01433835
- Testing
- MBX-400
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Microbiotix, Inc.
Influenza
Immunogenicity and Safety Evaluation of QIS in Healthy Subjects
The purpose of this study was to evaluate the antibody response to each of the four influenza vaccine strains included in the study vaccine, as measured by hemagglutination inhibition (HAI) at 4 weeks after the last dose of the…
- Trial name
- NCT04101435
- Testing
- AdimFlu-S (QIS)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Adimmune Corporation
Healthy Volunteers
Annual Study to Investigate Inactivated Subunit Influenza Vaccine for the 2006/2007 Influenza Season in Europe.
Influenza (flu) viruses change continuously, therefore also the parts of viruses used in influenza vaccines can vary from year to year.
- Trial name
- NCT00346723
- Testing
- Influvac® subunit influenza vaccine for i.m./deep s.c.injection
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Pain, Physical Activity
Influence of Expectations on Change in Pain Perception After a 3 Min Wallsquat Exercise.
The purpose of this study is to investigate how expectations induced by information given prior to exercise influence the magnitude of exercise-induced hypoalgesia after a 3 min wallsquat exercise in healthy subjects.
- Trial name
- NCT03678662
- Testing
- Hypoalgesia expectation, Hyperalgesia expectation, Neutral
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Healthy
Comparative Randomized, Single Dose, Two-way Crossover Open-label Study to Determine the Bioequivalence of Gabapentin From Nerpentin 600 mg (Test ) F.C.T (Aman Pharma ,Egypt.) and Gabapentin From Neurontin 300 mg (Referance ) H.G.C. ( Pfizer Egypt)
This study is conducted with the aim to investigate whether any differences concerning the rate and extent of absorption exist between the test and the reference product, Test product was Nerpentine 600 mg Film coated Tablet…
- Trial name
- NCT04805827
- Testing
- Gabapentin, Neurontin
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pharma Guide CRO
Healthy Volunteers
A Study of the Absorption, Metabolism and Excretion of [14C]XZP-3621 in Human
This non-randomized, single group, open-label study will investigate the mass balance, routes of elimination, pharmacokinetics, metabolism, safety and tolerability of a single oral dose of [14C]XZP-3621 in healthy volunteers.
- Trial name
- NCT05836805
- Testing
- [14C]XZP-3621
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Healthy
Electrical Stimulation With Different Currents: the Effects on Force, Tolerance and Fatigue in Healthy Subjects
Muscle strength is the amount of force generated by muscle contraction. It could be measured with an isometric dynamometer. This is a validated tool that could be used to measure Maximal Voluntary Isometric Contraction (MVIC) and…
- Trial name
- NCT03340337
- Testing
- Neo-Russian, Aussie, RBS
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Ciencias de la Salud Fundación H.A. Barceló
Renal Insufficiency, Pharmacokinetics
A Single Dose Study Investigating the Elimination as Well as the Tolerability of PD 0332334 in Healthy Subjects as Compared to Patients With Impaired Kidney Function.
1. To investigate the effect of kidney function on the elimination of a single dose of PD 0332334 from the body. 2. To investigate the safety and tolerability of a single dose of PD 0332334 in patients with impaired kidney…
- Trial name
- NCT00721422
- Testing
- PD 0332334
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Subjects
Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Relative to Originator
The study is to compare the rate and extent of absorption of a generic formulation with that of a reference for mulation when given as equal labeled dose.
- Trial name
- NCT06233201
- Testing
- Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Test product, Sitagliptin and Metformin Hydrochloride Tablets 50 mg/500 mg Reference product
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bio-innova Co., Ltd
Cognitive Performance
Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief…
- Trial name
- NCT00740701
- Testing
- Cerebellar transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy Volunteers
A Study Comparing Blood Levels After Single-Dose Administration Of Artesunate Sachets (Pfizer) Versus Single-Dose Administration Of Arsuamoon® Tablets (Guilin-China) In Healthy Subjects
The primary objective of the study is to determine bioequivalence of 50 mg (2x25 mg) Artesunate Sachet (Pfizer) versus 50 mg (1x50 mg) tablet, Arsuamoon® (Guilin China) which is the World Health Organization Reference standard…
- Trial name
- NCT00875030
- Testing
- artesunate sachets, Arsuamoon
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers
A Study to Assess Adverse Events, Tolerability and How Single and Ascending Oral Doses of Nacresertib Move Through the Body In Healthy Adult Participants
The objectives for this 2 Part study are to assess the safety, tolerability, and pharmacokinetics following single ascending oral doses of nacresertib in healthy adult participants (Part 1) and to assess the safety, tolerability…
- Trial name
- NCT07566130
- Testing
- nacresertib
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy, Nerve Block
HFAC Stimulation (30-50 Kilohertz) in Healthy Volunteers (High Frequency Alternating Current Stimulation)
High-frequency alternating current (HFAC) stimulation (between 1 kilohertz (kHz) and 100 kHz) on the peripheral nerve has been shown in basic animal research to produce a rapidly reversible nerve block without nerve damage.
- Conditions
- Healthy, Nerve Block, Pain
- Trial name
- HFA (NCT05230836)
- Testing
- High-frequency alternating current stimulation
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Brugada Syndrome, Sudden Death
The Response To Ajmaline Provocation in Healthy Subjects
Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes.
- Trial name
- NCT02933437
- Testing
- Ajmaline
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
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