Clinical trials: Healthy Volunteer Subjects
Atrial Fibrillation
Effect of BMS-914392 on Pharmacokinetics of Metoprolol
The purpose of the study is to assess the effects of BMS-914392 administration on the pharmacokinetics of a single-dose of metoprolol in healthy subjects.
- Trial name
- NCT01211821
- Testing
- metoprolol, BMS-914392
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hyperlipidemia
Relative Bioavailability Study of Lipidil® Supra (Fenofibrate 160mg) Versus SYO-0805 (Fenofibrate 65mg)
The purpose of this study is to evaluate the bioequivalence of Lipidil® Supra (fenofibrate 160mg) versus SYO-0805 (fenofibrate 65mg) in single dose oral administration.
- Trial name
- NCT01353404
- Testing
- Sequence 1, Sequence 2, Seqeunce 3
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Samyang Biopharmaceuticals Corporation
COVID-19, SARS-CoV-2 Infection
rSIFN-co Among Healthy Subjects and Subjects With Mild or Asymptomatic COVID-19
This is a phase II pilot, international, multicenter, randomized, double-blind, placebo-controlled study that aims to evaluate the safety and preliminary efficacy of rSIFN-co nasal spray in healthy subjects in close contact with…
- Trial name
- NCT05485584
- Testing
- rSIFN-co Nasal Spray
- Where
- 2 sites in Philippines
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Sichuan Huiyang Life Science and Technology Corporation
Intubation, Nasogastric
Safety and Efficacy Study of the NG Shield, a Device Intended to Reduce Pain and Discomfort Level Related to Nasogasstric Tube Usage
The purpose of the study i to demonstrate the safety and efficacy of a device that intends to reduce pain/discomfort related to nasogfastric tube usage by reducing the friction between the tube and internal orifice (nose and…
- Trial name
- NCT00781248
- Testing
- NG Shield
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nanovibronix
Alzheimer's Disease
A Study to Evaluate the Effect of Bexarotene on Beta-Amyloid and Apolipoprotein E Metabolism in Healthy Subjects
The primary objective of this proof of mechanism pilot clinical trial is to determine if the RXR agonist bexarotene acts in humans to alter the CSF levels of apoE and alter the clearance of Amyloid-Beta
- Trial name
- NCT02061878
- Testing
- Bexarotene
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ReXceptor, Inc.
Healthy
A Food Effect Phase I Study of the Sulfatinib in Healthy Subjects (HMPL-012)
The purpose of this study is to evaluate to determine the effect of food on the PK of a single dose of 250 mg Sulfatinib and its metabolites in healthy subjects.
- Trial name
- NCT02320409
- Testing
- Sulfatinib
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hutchison Medipharma Limited
Healthy Subjects
Bioequivalence Study of Ribavirin in Healthy Adult Subjects Under Fed Condition
To evaluate and compare the relative plasma bioavailability and therefore the bioequivalence of two different immediate release products each containing Ribavirin 400 mg, after administering a single oral dose, to healthy adult…
- Trial name
- NCT05532306
- Testing
- Ribavirin 400 mg film coated tablet (1*400mg), Copegus® 200 mg film coated tablet (2*200mg)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Bioavailability, B-cell Lymphoid Cancer
A Study to Evaluate Relative Bioavailability, Proton Pump Inhibitor (PPI) (Rabeprazole) Effect, Food Effect and Particle Size Effect of New Acalabrutinib Tablet in Healthy Subjects
This study will be a 2-part, open-label, single-center relative bioavailability, PPI effect, food-effect and particle size effect randomized crossover study of acalabrutinib tablets in healthy subjects (males or females).
- Trial name
- NCT04488016
- Testing
- Treatment A- Part 1, Treatment B- Part 1, Treatment C - Part 1
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)
This placebo-controlled crossover study is intended to measure the effect of four doses of lorazepam on brain activity measured by magnetoencephalography (MEG) and electroencephalography (EEG).
- Trial name
- NCT01272778
- Testing
- Lorazepam
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.
Pharmacokinetics in Healthy Adults
Single Ascending Dose Study With BPL-003 in Healthy Subjects
The study will evaluate safety, tolerability and PK profile of BPL-003 in healthy subjects
- Trial name
- NCT05347849
- Testing
- BPL-003
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Beckley Psytech Limited
Healthy
A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06273340 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56-75 Years (Group 2)
The purpose of this study is to investigate safety, toleration and time course of plasma concentration of multiple oral doses of PF-06273340 for 14 days in healthy subjects of two age groups, aged 18-55 years (Group 1) and aged…
- Trial name
- NCT01934738
- Testing
- PF-06273340
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Single Rising Dose Study of BI 690517 in Healthy Volunteers
To investigate safety, tolerability, pharmacokinetics and pharmacodynamics following single rising doses of BI 690517
- Trial name
- NCT02891148
- Testing
- BI 690517
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
The PK and PD Interaction Between YH4808, Amoxicillin and Clarithromycin in Healthy Subjects
The objective of this study is not only to explore pharmacokinetic interaction after single oral administration but also pharmacodynamics interaction after multiple oral administration of YH4808, amoxicillin and clarithromycin…
- Trial name
- YH4808-108 (NCT01921647)
- Testing
- YH4808, Nexium, Amoxicillin
- Where
- South Korea
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Malaria
Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study
This study is an open-label, two-part study to determine the absolute bioavailability (BA) of OZ439 using simultaneous intravenous [14C]-OZ439 microdose/800mg oral dosing and to investigate the pharmacokinetics (PK) of OZ439…
- Trial name
- NCT04069221
- Testing
- Single oral dose of 800 mg OZ439, Single oral dose of 400 mg OZ439, Single oral dose of cobicistat
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema
Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)
The study will include 60 healthy subjects (ex-smoker without any airflow limitation), 125 COPD GOLD (global initiative for chronic obstructive lung disease) I , 125 COPD GOLD II, 125 COPD GOLD III and up to 20 patients with COPD…
- Trial name
- NCT02719184
- Where
- 51 sites in United States, Belgium and 10 more
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy, no Evidence of Disease, Skin Cancer
Vitamin D Levels in the Skin of Healthy Subjects After Oral Supplementation
This pilot phase I trial studies vitamin D levels in the skin of healthy subjects after oral supplementation. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT01447355
- Testing
- cholecalciferol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Lewy Body Disease
A Phase I Study of GT300 in Healthy Subjects
Descriptive safety and pharmacokinetics of GT300, exploratory biomarker effects for the evaluation of the effect of GT300 on the autophagy-lysosomal pathway (ALP), food effect on PK and fasting effect on biomarkers.
- Trial name
- NCT04963855
- Testing
- GT300, Microcrystalline cellulose
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Generian Pharmaceuticals, Inc.
Healthy
The Effect of Grape Consumption on Increasing the Good Bacteria in the Human Intestine
This pilot study will assess the ability of daily consumption of one dose (2 servings) of freeze-dried whole table grape powder, made from conventionally grown grapes to alter the composition of the bacteria that live in the…
- Trial name
- NCT05025189
- Testing
- Table Grape Powder, Beige Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Exocrine Pancreatic Insufficiency, Chronic Pancreatitis
A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects
The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.
- Trial name
- NCT07285863
- Testing
- Secretin (human synthetic) - ChiRhoClin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
A Study to Assess the Effect of Ticlopidine on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants
The purpose of this study is to evaluate the effects of ticlopidine on the pharmacokinetics (PK) of intranasally administered esketamine.
- Trial name
- NCT03298906
- Testing
- Esketamine, Ticlopidine
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
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