Clinical trials: Healthy Volunteer Subjects
HBV
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Entecavir Extended Release (XR) in Healthy Subjects
This is a phase 1, randomized, parallel-group, single-center study in healthy adult subjects. The study will be conducted in two parts sequentially: Part 1 is an open-label, two-arm, active-controlled design to evaluate the PK…
- Trial name
- NCT03239353
- Testing
- Entecavir
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aucta Pharmaceuticals, Inc
Healthy Volunteer
A Single- and Multiple-Dose Study of the Pharmacokinetics of TAK-491 in Healthy Chinese Participants
The purpose of this study is to assess the pharmacokinetics and safety of single- and multiple-dose of TAK-491 in healthy Chinese participants.
- Trial name
- NCT02541669
- Testing
- TAK-491
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Takeda
Chronic Constipation
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
This study aim was to evaluate the effect of pharmacological treatments normally used to treat functional constipation and in particular PEG, bisacodyl and prucalopride on colonic motility as assessed by high-resolution manometry.
- Trial name
- NCT03279341
- Testing
- polyethylene glycol, Bisacodyl, Prucalopride
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Healthy Subjects
Orthopaedic Simulation of Morton's Extension to Test the Effect on Plantar Pressures of Each Metatarsal Head in Patients Without Deformity: A Pre-post-test Study.
The aim of this study is to simulate the orthopedic treatment called Morton's extension on non-deformed patients to check the effects on each metatarsal head on its static footprint.
- Trial name
- NCT05879094
- Testing
- Morton extension
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayuben Private Clinic
Healthy Subjects, Mental Health Issue
A Music and Visual Arts Digital Intervention in Teenagers to Promote Healthy Engagement With Social Media.
The primary goal of this interventional study is to explore whether 3 months of arts-based digital interventions can change the way in which teenagers (13-16 years of age) use social media and are affected by them.
- Trial name
- SMART (NCT06402253)
- Testing
- Music composition / edition, Photography composition / edition
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- New York University
Arthroplasty, Replacement, Knee
Study to Evaluate Safety, PK and PD of Single and Multiple Ascending Doses of EP-7041 in Healthy Subjects
This First-In-Human study will evaluate the safety and tolerability, pharmacokinetic profile, and pharmacodynamic effects of EP-7041, a novel Factor XIa inhibitor, following IV administration of single ascending doses in healthy…
- Trial name
- NCT02914353
- Testing
- EP=7041
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- eXIthera Pharmaceuticals
Excessive Somnolence
VSF-173 Study in Healthy Adult Volunteers for Treatment of Induced Excessive Sleepiness
The purpose of this study is to determine the safety and efficacy of VSF-173 compared to placebo in treatment of induced excessive sleepiness.
- Trial name
- NCT00467441
- Testing
- VSF-173
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Healthy
This Study Will Evaluate The Relationship Between Plasma Drug Levels And Receptor Binding In Brain Using PET (Positron Emission Tomography) In Healthy Volunteers
The purpose of this study is to evaluate the relationship between plasma drug levels and receptor binding in brain using PET; and to evaluate safety and tolerability after a single administration of PF-05212377 in healthy…
- Trial name
- NCT01258751
- Testing
- PF-05212377
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects
The acute subjective effects of serotonin (5-HT)2A receptor stimulation with lysergic acid diethylamide (LSD) in humans are mostly positive.
- Trial name
- LSD-MDMA (NCT04516902)
- Testing
- Lysergic Acid Diethylamide, 3,4-methylenedioxymethamphetamine
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
A Study To Evaluate The PDE10 Enzyme Occupancy Following A Single Dose Of PF-02545920 In Healthy Male Volunteers
This Phase 1 study will evaluate PDE10 enzyme occupancy using Positron Emission Tomography after a single dose of PF-02545920 in Healthy male volunteers.
- Trial name
- PET (NCT01918202)
- Testing
- 20 mg PF-02545920, PF-02545920
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Hereditary Angioedema
An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates
This is an open-label, single sequence study to evaluate the effect of BCX7353 on hepatic and intestinal cytochrome P450 enzymes using probe substrate drugs in healthy subjects.
- Trial name
- NCT02819102
- Testing
- BCX7353 and probes
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Healthy
Drospirenone/Ethinyl Estradiol (3 mg/0.02 mg) Tablets Under Non-Fasting Conditions
This study was designed to compare the relative bioavailability (rate and extent of absorption) of 3 mg/0.02 mg Drospirenone/Ethinyl Estradiol Tablets with that of YAZ® Tablets (by Berlex, Inc.) following a single, oral dose (2 x…
- Trial name
- NCT01182207
- Testing
- Drospirenone/Ethinyl Estradiol (Gianvi®), YAZ®
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)
The purpose of this study is to evaluate the potential for cardiac repolarization, according to electrocardiographic monitoring (including QT and QTc intervals), of two dose levels of CHF5993 pMDI (beclomethasone…
- Trial name
- NCT05830071
- Testing
- CHF5993, CHF5259, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Healthy Subjects
Study in Healthy Subjects to Measure the Effects of Food on the Pharmacokinetics of TC-5214
(Food versus no food) crossover study to measure the effects of food on pharmacokinetics of TC-5214 (S-Mecamylamine) in healthy Subjects.
- Trial name
- TC-5214 (NCT01458899)
- Testing
- TC-5214
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Phase I Study in Healthy Volunteers to Assess Safety of BMS747158
The purpose of this clinical research study is to learn the safety and biodistribution of BMS747158 in normal, healthy volunteers.
- Trial name
- NCT00707499
- Testing
- BMS747158
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Lantheus Medical Imaging
Osteoarthritis
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacology of ONO-4474 in Healthy Volunteers
A Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacology of ONO-4474 in healthy volunteers.
- Trial name
- NCT02454387
- Testing
- ONO-4474 Part A1, ONO-4474 Part A2, ONO-4474 Part B
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Infections, Human Immunodeficiency Virus and Tuberculosis
A Phase 1, Open Label, Placebo-Controlled Study to Evaluate the Effect of GSK1349572 on Iohexol and Para-Aminohippurate Clearance in Healthy Subjects
The current study is designed to confirm the mechanism behind the increase in serum creatinine observed during GSK1349572 therapy; specifically, the study will determine whether GSK1349572 has any effect on glomerular filtration…
- Trial name
- NCT01214993
- Testing
- GSK1349572, Iohexol Injection, Para-aminohippurate infusion
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Diabetes Mellitus
The Pharmacokinetics, Safety and Tolerability of IN-C009 in Healthy Subjects
This study was conducted as a randomized, open-label, single-dose, crossover study design. All participants were randomly allocated for group A (Period 1: Individual components (ICs), period 2: FCDP) and group B (Period 1: FCDP…
- Trial name
- NCT05066516
- Testing
- FCDP, dapagliflozin 10mg/linagliptin 5 mg or co-administration of a single dose of dapagliflozin and linagliptin
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Healthy Subjects
A First-In-Human Study of Single and Multiple Ascending Doses of Oral SUL-238 in Healthy Subjects
The goal of this randomized, double-blind, placebo-controlled, single-center study is to evaluate the safety, tolerability, pharmacokinetics of single and multiple oral doses of SUL-238 in healthy subjects (aged ≥40 years).
- Trial name
- NCT06277492
- Testing
- Single ascending doses SUL-238, Single dose SUL-238, Multiple ascending doses SUL-238
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- GEN İlaç ve Sağlık Ürünleri A.Ş.
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