Clinical trials: Hearing Disorders
Tinnitus
Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus
Tinnitus, or ringing in the ears, is a very common problem that often accompanies hearing loss. It affects up to 1 in 10 adults, and about 30% of people who experience chronic tinnitus find it very distressing.
- Trial name
- NCT03336398
- Testing
- Ketamine Hydrochloride in saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- New York State Psychiatric Institute
Hearing Impairment
The EarLens System Long Term Safety and Efficacy Definitive Multi-Center Study
The EarLens System is an assistive hearing device that is intended to provide amplification for the treatment of patients with sensorineural hearing impairment.
- Trial name
- NCT02042404
- Testing
- Sound amplification provided via EarLens System.
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- EarLens Corporation
Hearing Loss
Bilateral Benefit in Adult Users of the HiRes 90K Bionic Ear System
Normal hearing listeners gain important everyday benefits from listening with two ears (bilateral hearing) compared to their baseline performance with hearing aids.
- Trial name
- NCT00205881
- Testing
- HiRes 90K Bionic Ear System
- Where
- 9 sites in United States
- Volunteers
- 32 people
- Sponsor
- Advanced Bionics
Tinnitus
Efficacy of the Erchonia Corporation THL™ for Providing Relief of Tinnitus Symptoms
The purpose of this clinical study is to determine the effectiveness of the Erchonia® THL™, manufactured by Erchonia Corporation (the Company), for prescription home use in providing relief of tinnitus symptoms when used by…
- Trial name
- NCT05374421
- Testing
- Erchonia® THL™
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Erchonia Corporation
Sudden Deafness
Sudden Deafness Treatment Trial
This trial aims to compare the efficacy of oral prednisone vs. methylprednisolone injected into the middle ear for the treatment of moderate-to-severe, sudden sensorineural hearing loss (inner ear hearing loss affecting one ear…
- Trial name
- SSNHL (NCT00097448)
- Testing
- prednisone, methylprednisolone sodium succinate
- Where
- 14 sites in United States
- Volunteers
- 255 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Hearing Impairment, Sensorineural
A Feasibility Study Evaluating the Performance of Focused Multipolar Stimulation and Sound Coding in Adults.
The purpose of this early feasibility study is to explore several facets of hearing performance of Focused Multipolar stimulation in adult cochlear implant users.
- Trial name
- SASC (NCT05641155)
- Testing
- Focused Multipolar Stimulation (FMS) strategy
- Where
- 5 sites in United States, Belgium
- Volunteers
- 18 people
- Sponsor
- Cochlear
Tinnitus
Neuro-Music-Therapy for Patients With Chronic Tinnitus - a Controlled Clinical Trial
BACKGROUND: Tinnitus is a nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear.
- Trial name
- NCT01845155
- Testing
- Neuro-Music-Therapy according to the Heidelberg Model, Counselling
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- German Center for Music Therapy Research
Hearing Loss, Sensorineural
Hearing Study: Sensitivity to Features of Speech Sounds
The purpose of this study is to better understand the sensitivity of listeners to the fast changes in frequency or amplitude of sounds that occur in speech.
- Trial name
- NCT03666676
- Testing
- Signal processing to improve intelligibility
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Meniere's Disease
SPI-1005 for the Treatment of Patients With Meniere's Disease
This study will evaluate the safety, efficacy, and Pharmacokinetics (PK) of two dose levels of SPI-1005 administered for 28 days compared to placebo in patients with Meniere's disease.
- Trial name
- NCT03325790
- Testing
- 200mg SPI-1005 BID, 400mg SPI-1005 BID
- Where
- 13 sites in United States
- Volunteers
- 149 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Tinnitus
Clinical Trial of Sound-Based Versus Behavioral Therapy for Tinnitus
The purpose of this study is to determine if a novel sound-based therapy in comparison to standard of care (cognitive behavioral therapy) results in reducing tinnitus-related effects for people with bothersome tinnitus.
- Trial name
- NCT03022084
- Testing
- Desyncra, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- VA National Center for Rehabilitative Auditory Research
Sudden Sensorineural Hearing Loss
Oral Statins and Protection From Hearing Loss
A small clinical trial for idiopathic sudden sensorineural hearing loss (ISSNHL). Will the addition of an oral statin to the standard treatment (oral methylprednesolone and the salvage therapy of intratympanic dexamethasone)…
- Trial name
- NCT04826237
- Testing
- Statin, methylprednisolone, dexamethasone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Presbycusis, Aging
Evaluating Hearing Aid Service Delivery Models
The purpose of this study is to compare the outcomes for two different hearing-aid delivery models. In one model, the audiologist selects and fits the hearing aid and, in the other model, the consumer does this directly.
- Conditions
- Presbycusis, Aging, Hearing Loss
- Trial name
- NCT01788423
- Testing
- hearing aid
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Indiana University
Tinnitus
Auditory-somatosensory Stimulation to Alleviate Tinnitus
The purpose of this study is to develop and test a subject operated device to lessen tinnitus (ringing in the ear), based on subject-feedback for stimulus presentation.
- Trial name
- NCT02974543
- Testing
- Active Treatment: Bimodal auditory-somatosensory stimulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Tinnitus
High Dose Oxytocin Nasal Spray for Treatment of Tinnitus
The purpose of this study is to evaluate the effects of high-dose intranasal oxytocin for treating tinnitus. The hypothesis is that high dose intranasal oxytocin can significantly reduce tinnitus severity and disability.
- Trial name
- NCT04210310
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- NYU Langone Health
Hearing Impairment
The Performance-Perceptual Test as a Counseling Tool
The purpose of the study is to determine whether a new test of ability to understand speech in noise and an associated counseling program can improve hearing aid satisfaction.
- Trial name
- PPT (NCT00126113)
- Testing
- PPT-based Counseling, Standard Educational Counseling
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Sensorineural Hearing Loss, Noise Induced Hearing Loss
FX-322 in Adults With Stable Sensorineural Hearing Loss
This is a phase 2a single and repeat dose exploratory efficacy study of intratympanic FX-322 compared to placebo in healthy male and female adults with stable sensorineural hearing loss.
- Conditions
- Sensorineural Hearing Loss, Noise Induced Hearing Loss, Sudden Sensorineural Hearing Loss
- Trial name
- NCT04120116
- Testing
- FX-322 (One Dose), FX-322 (Two Doses), FX-322 (Four Doses)
- Where
- 16 sites in United States
- Volunteers
- 95 people
- Sponsor
- Frequency Therapeutics
Hearing Loss
Antioxidation Medication for Noise-induced Hearing Loss
This study will examine whether oral intake of 1200mg N-Acetylcysteine/day will prevent temporary threshold shift in hearing among workers exposed to noise
- Trial name
- NCT00552786
- Testing
- N-acetylcysteine (NAC), glucose
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hearing Loss
Cochlear Implantation in Adults With Asymmetric Hearing Loss Clinical Trial
This longitudinal study evaluates the possible benefit of cochlear implantation in the poor ear of adults with asymmetric hearing loss who continue to use a hearing aid in the better hearing ear.
- Trial name
- NCT03052920
- Testing
- Cochlear implant
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Tinnitus, Pulsatile Tinnitus
Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis
There have been few published studies that examine the efficacy and safety of endovascular treatments on patients with pulsatile tinnitus with venous stenosis.
- Conditions
- Tinnitus, Pulsatile Tinnitus, Venous Sinus Stenosis, Dural Sinus Stenosis
- Trial name
- NCT02734576
- Testing
- Venous Sinus Stenting with the Precise Pro Stent
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University