Clinical trials: Hearing Loss, Sudden
Sudden Sensorineural Hearing Loss
Phase I Clinical Study of HY01 in Patients
Phase I clinical study on the safety, tolerance, efficacy and pharmacokinetics of repeated intratympanic HY01 in patients with sudden sensorineural hearing loss.
- Trial name
- NCT04961099
- Testing
- HY01
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Heyu (Suzhou) Pharmaceutical Technology Co., Ltd
Sudden Sensorineural Hearing Loss
Small Sample，Unicentric，Randomized, Controlled Clinical Study of Coenzyme I for Injection in the Treatment of Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss is one of the most common emergencies in otorhinolaryngology, and its incidence is increasing year by year and tends to be younger.
- Trial name
- NCT05849519
- Testing
- Coenzyme I for Injection + conventional treatment, Conventional treatment
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sudden Sensorineural Hearing Loss
Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss
The annual incidence of sudden sensorineural hearing loss (SSNHL) is 5 to 20 per 100 000 persons. The pathophysiology of SSNHL and acute vestibulo-cochlear syndromes (VCS) is unknown in more than 70% of cases.
- Trial name
- SERORL (NCT07113158)
- Testing
- Aspirin + Acid folic
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sudden Hearing Loss
Trans-round Window Membrane Intracochlear Steroid
Safety and efficacy of intracochlear injection of glucocorticoid through the round window membrane in patients with profound or complete sudden sensorineural hearing loss
- Trial name
- NCT07540728
- Testing
- Experimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Vestibular Disorder
Vestibular Function and Vestibular Rehabilitation in SSHL With Vertigo
To evaluate the vestibular function and vestibular rehabilitation in sudden sensorneural hearing loss(SSHL) with vertigo
- Trial name
- NCT03431506
- Testing
- Vestibular rehabilitation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Idiopathic SSNHL, Age Over 18
Blood Markers in Adult Patients With Sudden Sensorineural Hearing Loss (SSNHL)
The roles of thrombophilia and cardiovascular risk factors in sudden sensorineural hearing loss (SSNHL) remain controversial. Cochlear micro-thrombosis has been hypothesized as a possible pathogenic mechanism of SSNHL.
- Trial name
- SSNHL (NCT03919474)
- Testing
- microvascular markers
- Where
- France
- Volunteers
- 394 people
- Sponsor
- Hopital Lariboisière
Autoimmune Inner Ear Disease
The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease
The purpose of this study is to determine if gevokizumab therapy may be an alternate therapy in patients with steroid resistant Autoimmune Inner Ear Disease.
- Trial name
- NCT01950312
- Testing
- gevokizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- XOMA (US) LLC
Sudden Sensorineural Hearing Loss (SSNHL), Hyperbaric Oxygen Therapy
Effect of Hyperbaric Oxygen Therapy(HBOT) on Patients With Sudden Sensorineural Hearing Loss(SSNHL) and Coagulation Function
The objective of this observational study was to understand the effect of HBO on patients with SSNHL and its association with coagulation function and prognosis.
- Trial name
- NCT06819202
- Testing
- Hyperbaric oxygen treatment
- Where
- China
- Volunteers
- 1,309 people
- Sponsor
- Sun Yuting
Sudden Sensorineural Hearing Loss
Speech Perception Impairment Follow Complete Recovery of Sudden Sensorineural Hearing Loss
At present, few research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing.This project evaluate the speech…
- Trial name
- NCT05608161
- Testing
- speech in noise test
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Sensorineural Hearing Loss, Autoimmune Inner Ear Disease
A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
The purpose of this study is to determine if Anakinra (an interleukin-1 receptor antagonist) can improve hearing thresholds in those patients with Autoimmune Inner Ear Disease (AIED) that did not respond to oral steroid therapy…
- Trial name
- NCT01267994
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Andrea Vambutas
Presbycusis, Hearing Loss, Sensorineural
FX-322 in Adults With Age-Related Sensorineural Hearing Loss
This is a Phase 1b, prospective, randomized, double-blind, placebo-controlled, single-dose, multicenter, safety study of FX-322, administered by intratympanic injection, in adults with age-related sensorineural hearing loss.
- Conditions
- Presbycusis, Hearing Loss, Sensorineural, Noise Induced Hearing Loss, Sudden Hearing Loss
- Trial name
- NCT04601909
- Testing
- FX-322
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Frequency Therapeutics
Sudden Deafness, Sensorineural Hearing Loss
Autologous Blood Monocyte Vesicles for the Treatment of Sudden Deafness
Sudden deafness is a common emergency in otorhinolaryngology. As the etiology and mechanism of sudden deafness remains unknown, there is no specific treatment.
- Trial name
- NCT06707389
- Testing
- autologous blood monocyte vesicles (lower dose), Methylprednisolone, autologous blood monocyte vesicles (higher dose)
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sudden Hearing Loss
Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is diagnosed when there's a sudden drop in hearing of at least 30 decibels across three consecutive frequencies, emerging within up to 72 hours.
- Trial name
- NCT06467526
- Testing
- Hydroxychloroquine, Steroid
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Eustachian Tube Dysfunction, Sudden Hearing Loss
What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube?
Pilot study done to evaluate the breakdown and and potential utility of a bioabsorbable ventilation ear tube made with gelatin.
- Conditions
- Eustachian Tube Dysfunction, Sudden Hearing Loss, Meniere Disease
- Trial name
- NCT04902963
- Testing
- PE tube
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Skovlund Medical Products, LLC
Sudden Hearing Loss, Obstructive Sleep Apnea
The Effect of PAP on ISSHL Comorbided With OSA
This clinical randomized controlled study is to explore the effect of positive airway pressure(PAP) on patients in Beijing Tsinghua Changgung Hospital diagnosed with both idiopathic sudden sensorineural hearing loss…
- Trial name
- NCT04192656
- Testing
- non-invasive positive airway pressure, Methylprednisolone Hemisuccinate, Ginaton
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Sudden Hearing Loss
Effectiveness of Integrative Medical Treatment in Sudden Hearing Loss
Sudden hearing loss is an emergency in otolaryngology that requires diagnosis and treatment as soon as possible. The golden treatment period is two weeks since the onset of the disease.
- Trial name
- NCT07235488
- Testing
- Acupuncture, steroid therapy
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital
Sudden Hearing Loss, Sensorineural Hearing Loss
Yiyuancong for the Treatment of Sudden Sensorineural Hearing Loss
This project aims to evaluate the clinical efficacy of Yiyuancong, an independently developed traditional Chinese medicine (TCM) formula based on the homology of medicine and food, in participants with sudden sensorineural…
- Trial name
- NCT07505667
- Testing
- Standard treatment combined with Yiyuancong, Standard treatment
- Where
- 5 sites in China
- Volunteers
- 128 people
- Sponsor
- Guangdong Provincial People's Hospital
Hearing Loss
Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss
The purpose of the study is to determine whether AM-111 is effective in the treatment of acute inner ear hearing loss (acute sensorineural hearing loss, ASNHL).
- Trial name
- NCT00802425
- Testing
- AM-111
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Auris Medical AG
Obstructive Sleep Apnea, Sudden Hearing Loss
OSA and Sudden Sensorineural Hearing Loss
This study studies the prevalence between obstructive sleep apnea syndrome and sensorineural hearing loss. We recruit patients who have been treated for sudden sensorineural hearing loss in Poitiers' University Hospital between…
- Trial name
- SAS-SB (NCT03747874)
- Testing
- ventilatory polygraphy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Hearing Loss, Sudden Deafness
The Effect of Antiviral Therapy With Pegylated Interferon-alpha on Auditory Disability
The aim of the study is to assess the effect of antiviral therapy with pegylated interferon alpha for hepatitis C and B on auditory disability as there are reports in the English literature on auditory disability caused by…
- Trial name
- HLIPT2010 (NCT01265693)
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center