Clinical trials: Hearing-Impairment
Sensorineural Hearing Loss, Bilateral, Cochlear Implant
Clinical Investigation of New CI Delivery Models in an Adult Nucleus CI Population
Use of Artificial Intelligent (AI) technology to assist audiologists in programming cochlear implants.
- Trial name
- NCT03304106
- Testing
- Commercially available cochlear implant and AI system
- Where
- 9 sites in United States
- Volunteers
- 102 people
- Sponsor
- Cochlear
Hearing Loss, Conductive, Hearing Loss, Mixed
Expanded Indications in the Pediatric BONEBRIDGE Population
This study will assess safety and efficacy of the MED-EL BONEBRIDGE Bone Conduction Implant in children under 12 years old with conductive or mixed hearing loss.
- Trial name
- NCT05615649
- Testing
- MED-EL BONEBRIDGE Bone Conduction Implant
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- Med-El Corporation
Deafness, Blindness
Workshops for Veterans With Vision and Hearing Loss
This is a pilot study of workshops to help Veterans with both vision and hearing loss live a happier, fuller and less stressful life. The results will be used to guide the development of a large scale clinical trial.
- Trial name
- DSLW (NCT01109576)
- Testing
- DSL Workshop
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- US Department of Veterans Affairs
Hearing Loss
Bilateral Cochlear Implantation in Children With the MED-EL Cochlear Implant
The purpose of this study is to evaluate and document longitudinal efficacy in young children implanted bilaterally with MED-EL COMBI 40+ / PULSARCI100/SONATATI100 cochlear implant systems.
- Trial name
- NCT00784043
- Testing
- Cochlear Implant
- Where
- 9 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Med-El Corporation
Tinnitus, Hearing Loss
Neuro-feedback Therapy for Treating Tinnitus
Neuro-feedback for treating tinnitus seem to be a promising approach to help people suffering from chronic tinnitus. The past studies on this approach suffered interindividual variability in their results.
- Trial name
- TNTA (NCT03773926)
- Testing
- Neuro-feedback therapy
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Zeta Technologies
Conductive Hearing Loss, Middle Ear
Ossiview Normative Mobility Data Collection Protocol
The goal of this observational study is to learn about the sound-induced vibration level of certain structures in the middle ear in the normal-hearing population.
- Trial name
- NCT06310278
- Testing
- Ossicular mobility measurement
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Audioptics Medical Incorporated
Sensori-Neural Deafness, Exosomes
A Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.
Primary Objective To compare the efficacy of a single course of IT Exo-Dex versus conventional IT dexamethasone and exosome vehicle alone, as measured by the mean change in pure-tone average (PTA; 0.5, 1, 2, 4 kHz) from baseline…
- Trial name
- EXO-DEX-SNHL (NCT07568184)
- Testing
- exosomes derived from human umbilical cord mesenchymal stem cells
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Usher Syndromes
Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome
This study will examine the safety and efficacy of NPI-001 Tablets as compared to placebo for 24 months in subjects with vision loss due to RP associated with Usher syndrome.
- Trial name
- SLO RP (NCT04355689)
- Testing
- NPI-001
- Where
- 4 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Nacuity Pharmaceuticals, Inc.
Hearing Loss, Sensorineural
Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy
Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.
- Trial name
- TREATGENE (NCT03996824)
- Testing
- Peroperative collect of inner ear cells
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut Pasteur
Hearing Loss
Telemonitoring in Cochlear Implant Patient Care
Following a sufficient delay after the cochlear implantation and initial implant activation, the patient will return to the hospital for follow-up visits for equipment maintenance and auditory performance evaluation only once per…
- Trial name
- EMPSICOT (NCT05566353)
- Testing
- Remote Check
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Montpellier
Sensorineural Hearing Loss
Clinal Evaluation of Navigation Based Functional Ear Surgery Using Image Guided and Robotically Assisted Techniques
To assess the feasibility of achieving a minimally invasive access to the inner ear through the navigation-based HEARO procedure and subsequently insert the electrode array of the cochlear implant through the access.
- Trial name
- EAR2OS (NCT03746613)
- Testing
- HEARO
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- Prof. Vedat Topsakal
Deafness, Hearing Loss
Speech Perception Performance With Gap-interleaved Stimulation Paradigms
Cochlear implants (CI) are used to help patients with severe to profound hearing loss regain auditory perception by electrical stimulation of the auditory nerve.
- Trial name
- NCT03937388
- Testing
- Cochlear stimulation strategy including time-fixed gaps
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Angelica Perez Fornos
Sudden Sensorineural Hearing Loss (SSNHL), Hyperbaric Oxygen Therapy
Effect of Hyperbaric Oxygen Therapy(HBOT) on Patients With Sudden Sensorineural Hearing Loss(SSNHL) and Coagulation Function
The objective of this observational study was to understand the effect of HBO on patients with SSNHL and its association with coagulation function and prognosis.
- Trial name
- NCT06819202
- Testing
- Hyperbaric oxygen treatment
- Where
- China
- Volunteers
- 1,309 people
- Sponsor
- Sun Yuting
Hearing Loss, Deafness
Auditory-Cognitive Training to Optimize Outcomes for Older CI Users
The proposed study will investigate whether an auditory brain training program can improve cochlear implant (CI) outcomes in older post-lingually deafened CI users.
- Trial name
- ARCog (NCT05176561)
- Testing
- Auditory-Cognitive Training, Non-auditory Cognitive Training
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gallaudet University
Hearing Loss, Hearing Aids
New Hearing Aid Users and Their Social Participation
Does first-ever hearing aid fitting change social participation? Using a mixed methods approach made up of audiological assessments (hearing test and examination of the ear canal and eardrum), questionnaires, semi-structured…
- Conditions
- Hearing Loss, Hearing Aids, Social Participation
- Trial name
- NCT07866586
- Testing
- Observation
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Brain Mapping, Deafness
Areas of Brain Responsible for Understanding American Sign Language
The human brain is made up of two halves called hemispheres. Each half of the brain is responsible for processing different kinds of information.
- Conditions
- Brain Mapping, Deafness, Healthy
- Trial name
- NCT00001782
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hearing Loss, Bilateral Sensorineural, Progressive
Quality Control of CE-Certified Phonak Hearing Aids - 2017_27
A methodical evaluation of new CE-labelled Phonak Hearing Systems is intended to be conducted on hard of participants with a hearing loss to grant quality control prior to product launch.
- Trial name
- NCT03253003
- Testing
- Line extension of the Phonak Audéo B product family
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- Sonova AG
Mild to Severe Sensorineural Hearing Loss
Esteem Totally Implantable Hearing System
To evaluate the safety and efficacy of the Esteem Totally Implantable Hearing System in subjects suffering from mild to severe hearing loss.
- Trial name
- NCT01092910
- Testing
- Esteem Totally Implantable Hearing System
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Envoy Medical Corporation
Hearing Loss
Lyric4 Outcomes Evaluation
The goal of this clinical investigation is to obtain feedback on Lyric4 device updates within a cohort of experienced adult Lyric hearing instrument users.
- Trial name
- NCT06169683
- Testing
- Lyric4
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Sonova AG
Age-related Hearing Impairment 1, Personal Communication
Baltimore HEARS: Hearing Health Equity Through Accessible Research & Solutions
Age-related hearing loss is highly prevalent and hearing health care is underutilized. The primary objective of the proposed randomized controlled trial is to investigate the efficacy of a community health worker (CHW)-delivered…
- Trial name
- HEARS (NCT03442296)
- Testing
- Baltimore HEARS
- Where
- 2 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University