Clinical trials: Heart; Complications
Gender Discrimination, Cardiac Event
AN OBSERVATIONAL STUDY ON CARDIOVASCULAR INVOLVEMENT IN COVID RECOVERED PATIENTS
Aim of the study is to evaluate the prevalence and bring awareness ofcardiovascular complications in COVID-19 recovered patients.
- Conditions
- Gender Discrimination, Cardiac Event, Complication
- Trial name
- NCT05710796
- Testing
- Difference in gender, response to disease, diagnostic test values
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Kakatiya University
Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment
Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients
The purpose of this prospective observational clinical cohort study is to develop a scientifically based approach to the prediction and early diagnosis of intestinal dysfunction in cardiac surgery patients.
- Conditions
- Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment, Cardiac Surgery, Cardiac Surgery in Adult Patient
- Trial name
- PREDICT-GICS (NCT07422246)
- Testing
- additional blood testing for specific and non-specific markers of intestinal dysfunction, ultrasound examination of abdominal organs and measurement of intra-abdominal pressure
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Pregnancy, Heart; Complications, Valve, Prosthesis
Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Pregnancy is associated with increased risk of thrombosis among women with mechanical prosthetic heart valves.However, the best anticoagulant treatment strategies for pregnant patients with prosthetic heart valves have been…
- Trial name
- NCT02240927
- Testing
- Low Molecular Weight Heparine : Enoxaparine, Enoxaparine and 2.5 mg Warfarin, Enoxaparine and 4mg Warfarin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Type 1 Diabetes, Coronary Artery Calcifications
Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes.
Objective: To investigate whether visceral adipose tissue (VAT) and its adipokines contribute to early signs of cardiovascular disease, meaning coronary artery calcifications (CAC) and diastolic dysfunction in type 1 diabetes…
- Conditions
- Type 1 Diabetes, Coronary Artery Calcifications, Diastolic Dysfunction
- Trial name
- VISCERA (NCT02689570)
- Testing
- observational
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
Postresuscitation disease is a constellation of disorders related to whole-body ischemia and reperfusion syndrome. It includes hypoxic damage in brain, liver, kidney, heart and other organ.
- Trial name
- NCT01987466
- Testing
- Serum NGAL level
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Yonsei University
Bladder Hyperactivity, Sacral Neuromodulation
Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation
Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence.
- Trial name
- ESTIME (NCT06434831)
- Testing
- Medical device for SNM: Interstim X or Interstim micro
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Disorder of Vitamin C, Atrial Fibrillation
High Dose Vitamin C in Cardiac Surgery Patients
Coronary artery bypass grafting (CABG) is the most common procedure performed by cardiac surgeons. Post-operative atrial fibrillation (AF) is the most common adverse event following CABG, experienced in 20-50% of patients; the…
- Conditions
- Disorder of Vitamin C, Atrial Fibrillation, Complications Due to Coronary Artery Bypass Graft, Heart Valve Disease
- Trial name
- NCT02762331
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Covid19, Cardiac Complication
One-year Cardiac Follow-up of Patients With COVID-19 Pneumonia
The primary objective of the study is to assess the cardiac status of COVID-19 pneumonia patients during 1 year after discharge
- Trial name
- NCT04501822
- Testing
- Evaluation of clinical, instrumental and laboratory diagnostics tests
- Where
- Russia
- Volunteers
- 380 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Sternal Wound Complications, Obesity (Body Mass Index >30 kg/m2)
Sternal Closure in High-BMI Patients: Cable vs Wire
This retrospective study compares two sternal closure techniques-standard stainless-steel wires and rigid cable systems-in adult patients with a body mass index (BMI) ≥30 who underwent open-heart surgery between January 1, 2020…
- Conditions
- Sternal Wound Complications, Obesity (Body Mass Index >30 kg/m2), Median Sternotomy, Cardiac Surgery
- Trial name
- NCT07097272
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Samsun University
Contrast Induced Acute Kidney Injury
Study of APX-115 in Contrast Induced Acute Kidney Injury in Subjects Undergoing PCI
This phase 2 study is to assess the safety and efficacy of APX-115 active doses in Contrast Induced Acute Kidney Disease compared to placebo following multiple oral dosing in patients with undergoing percutaneous coronary…
- Trial name
- NCT05758896
- Testing
- Isuzinaxib (APX-115)
- Where
- 14 sites in United States, South Korea
- Volunteers
- 218 people
- Sponsor
- Aptabio Therapeutics, Inc.
Inflammasomes, Cognitive Dysfunction
Correlation of NLRP3 With Cognitive Dysfunction Early After Heart Valve Replacement Surgery
The investigators decided to assess the prognostic value of NLRP3 inflammasome level in early after heart valve replacement surgery and whether it was related to postoperative cognitive dysfunction.
- Conditions
- Inflammasomes, Cognitive Dysfunction, Pyrin Domain-Containing 3 Protein, Postoperative Complications
- Trial name
- NCT04191642
- Where
- China
- Volunteers
- 75 people
- Sponsor
- General Hospital of Ningxia Medical University
Congenital Heart Defects
Cylexin for Reduction of Reperfusion Injury in Infant Heart Surgery
We conducted a multicenter, randomized, placebo-controlled trial of Cylexin, an inhibitor of the attachment of white blood cells to the endothelium.
- Trial name
- NCT00226369
- Testing
- CY-1503
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Chronic Kidney Diseases
Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes
Patient with complex comorbidities present a growing challenge for health-care providers, that the current system is poorly designed to handle.
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Cardiovascular Diseases, Chronic Disease
- Trial name
- CareHND (NCT03362983)
- Testing
- CareHND
- Where
- Sweden
- Volunteers
- 131 people
- Sponsor
- Danderyd Hospital
Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury
SIRAKI 02 Posthoc Analysis.
Our randomized controlled trial with 343 patients requiring non emergent cardiac surgery with a prolonged expected cardiopulmonary bypass (CPB) time (>90 minutes) demonstrated that the use of an extracorporeal blood purification…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury, Chronic Kidney Disease(CKD), Kidney Failure, Acute
- Trial name
- OXI-SAFE-CEC (NCT06781294)
- Testing
- Extracorporeal Cytokine hemadsorption therapy
- Where
- Spain
- Volunteers
- 343 people
- Sponsor
- Hospital Universitari de Bellvitge
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Decompensated Heart Failure (ADHF)
Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.
The aim of this clinical trial is to investigate whether pulsatile compression therapy can support heart and kidney function in patients admitted with acute heart failure and fluid accumulation in the legs.
- Trial name
- COMPLEX (NCT07377019)
- Testing
- Pulsatile Compression Boots (PCB)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
Thromboembolism, Deep Vein Thrombosis
DVT After Cardiac Procedure
Patients undergoing electrophysiology studies (EPS) and cardiac ablation procedure for the treatment of cardiac arrhythmias may be at increased risk of deep vein thrombosis (DVT) during or after the procedure, which may lead to…
- Trial name
- NCT03877770
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Manchester University NHS Foundation Trust
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