Clinical trials: Heart; Complications
Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis
Hypoxemia in Maintenance Hemodialysis Patients
Previous research has shown that many patients with kidney failure undergoing chronic hemodialysis (HD) have a very low venous oxygen concentration, which may further decrease during dialysis treatments.
- Conditions
- Oxygen Saturation and the Relationship to Other Cardiac Variables, Maintenance Hemodialysis, Kidney Failure, Chronic
- Trial name
- NCT03045796
- Testing
- Oxygen Saturation measured by WristOx
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
HFrEF - Heart Failure With Reduced Ejection Fraction, Chronic Kidney Disease
Swedish Cardiac And Renal Failure Study-1
Previous studies have shown that patients with heart failure with reduced pumping function and preserved kidney function experience improved symptoms, longer survival, and fewer hospitalizations when treated with medications such…
- Trial name
- SCARF-1 (NCT07029503)
- Testing
- Eplerenone
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Hypertension in Pregnancy, Gestational Hypertension
Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy (HDP) are now well-recognized risk factors for adverse outcomes in the postpartum period and for development of future cardiovascular disease (CVD).
- Conditions
- Hypertension in Pregnancy, Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia
- Trial name
- NCT04998942
- Testing
- virtual cardiac wellness program
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Bypass Surgery, Coronary Heart Disease
Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA
The purpose of this study is to assess the effects of nesiritide compared to placebo when given with standard of care therapies, on kidney function, heart function and the need of other treatments in heart failure patients…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00653042
- Testing
- Nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Sepsis, Respiratory Failure
Inert Gas Rebreathing in Ventilated Patients
Measuring hemodynamic parameters in ventilated patients is important yet still complicated to perform. Inert gas rebreathing (IGR) showed promising results when being compared to other invasive as well as non-invasive techniques…
- Conditions
- Sepsis, Respiratory Failure, Heart Failure, Renal Failure
- Trial name
- VIGR (NCT01891253)
- Testing
- non-invasive determination of cardiac output
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Kangaroo-mother Care
Skin-to-skin Contact Between Premature Infant and Mother
Aim: To determine the effect of kangaroo mother care (KMC) on perfusion index, heart rate, and oxygen saturation in premature infants who were discharged early and admitted to the neonatal intensive care in the following days.
- Trial name
- NCT06380231
- Testing
- kangaroo mother care (KMC)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Istanbul Rumeli University
Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of GDC-8264 in Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) and Major Adverse Kidney Events (MAKE)
The aim of this study is to evaluate the efficacy and safety of GDC-8264 compared with placebo in participants undergoing cardiac surgery who are determined to be at moderate to high risk of developing AKI and subsequent MAKE at…
- Trial name
- NCT06602453
- Testing
- GDC-8264
- Where
- 34 sites in United States, Australia and 10 more
- Volunteers
- 67 people
- Sponsor
- Genentech, Inc.
AF - Atrial Fibrillation, Complication
Esophageal Protection Study: A Multicenter Study
Atrial fibrillation (AF) is a common debilitating heart rhythm condition that can cause heart failure and negatively impact a patient's outlook in terms of symptoms and disability.
- Conditions
- AF - Atrial Fibrillation, Complication, Atrio-Esophageal Fistula
- Trial name
- NCT04577859
- Testing
- ensoETM. Esophageal cooling during AF ablation, Esophageal temperature monitoring probe
- Where
- 6 sites in United States, United Kingdom
- Volunteers
- 152 people
- Sponsor
- Advanced Cooling Therapy LLC, d/b/a Attune Medical
Myocardial Infarction
Patients With Non-ST-segment Elevation Acute Coronary Syndrome
There are two types of acute coronary syndrome (ACS): ACS with persistent ST segment elevation (ACS ST +) and ACS without ST segment elevation (non-ST + ACS).
- Trial name
- SCA (NCT05159973)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Surgery, Perioperative/Postoperative Complications
The Perioperative Management of Anti-thrombotic Drug Registry
The purpose of the study is to investigate contemporary antiplatelet therapy management of patients referred for non-cardiac and cardiac surgical procedures while on chronic therapy with antiplatelet and/or anticoagulant drugs.
- Trial name
- CNCS (NCT03695159)
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- University of Texas Southwestern Medical Center
End Stage Renal Disease / Hemodialysis
Mineralocorticoid Receptor Antagonists in End Stage Renal Disease
End stage renal disease (ESRD) patients exhibit an extraordinarily high annual mortality. Cardiovascular (CV) causes account for almost half of all-cause mortality.
- Trial name
- MiREnDa (NCT01691053)
- Testing
- Spironolactone
- Where
- 3 sites in Germany
- Volunteers
- 118 people
- Sponsor
- Wuerzburg University Hospital
Uric Acid
Uric Acid and Surgical Prognosis
Preoperative serum uric acid significantly impacted mortality and morbidity in non-cardiac surgery.
- Trial name
- NCT06837545
- Testing
- No Intervention (Observational Study)
- Where
- South Korea
- Volunteers
- 309,353 people
- Sponsor
- Asan Medical Center
Delirium, Postoperative, Cardiac Disease
Optic Nerve Sheath Diameter is Associated With Postoperative Delirium in Patients Undergoing Open Heart Surgery
Although the incidence of delirium after cardiac surgery is high, it is not sufficiently recognized. The long-term effects of delirium are likely to be underestimated.
- Conditions
- Delirium, Postoperative, Cardiac Disease, Cardiac Valve Disease
- Trial name
- NCT05942183
- Testing
- ONSD
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
Acute Kidney Injuries, Chronic Renal Diseases
Vitamin D Metabolites as Biomarkers for the Identification of Kidney Injury in Cardiac Surgery
The investigators will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine.
- Trial name
- VITAL (NCT06688994)
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Insufficiency, Acute Renal Insufficiency
The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury.
- Conditions
- Acute Kidney Insufficiency, Acute Renal Insufficiency, Acute Kidney Injury, Ischemic Preconditioning
- Trial name
- NCT00821522
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Robert Kramer, MD
Acute Kidney Injury, Cardiac
Pre-operative Exposure to SGLT2 Inhibitors and Post-operative Acute Renal Failure in Cardiac Surgery: a Retrospective Monocentric Cohort Study
Cardiac surgery with cardiopulmonary bypass exposes patients to the risk of post-operative acute kidney injury. In the specific setting of cardiac surgery, acute kidney injury is often of multifactorial origindue to particular…
- Conditions
- Acute Kidney Injury, Cardiac, Surgery
- Trial name
- SGLT2i (NCT06453161)
- Testing
- Post-operative acute kidney injury
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
Bypass Complication, Cardioplegia Solution Adverse Reaction
Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery
Investigating the myocardial effects of cold blood cardioplegia and del nido cardioplegia solution, which are routinely used in clinical practice, will contribute to the studies in the literature on the safety and efficacy of…
- Conditions
- Bypass Complication, Cardioplegia Solution Adverse Reaction, Endothelial Degeneration, Oxidative Stress
- Trial name
- NCT05603429
- Testing
- Endocan, E-Selectin, TNF-alpha, Total Oxidant and Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Surgical Site Infection
Medixair® System on Surgical Site Infection in Cardiac Patients
There is a growing incidence of sepsis and septic shock in people after surgery, for which there may be several reasons: more elderly people and more severe illnesses are entering operating theatres, more invasive systems are…
- Trial name
- NCT02492919
- Testing
- Medixair®
- Volunteers
- 1,000 people
- Sponsor
- University of Valladolid
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
IUGR, Fetal Growth Retardation
Cardiac Displacement From Third Trimester to Early Childhood
The aim is to increase awareness of the relationship between (IUGR) and cardiac function in the foetus, the development of cardiac function over time after delivery and what significance a possible early disturbed myocardial…
- Conditions
- IUGR, Fetal Growth Retardation, Intrauterine Growth Restriction
- Trial name
- CADETTE (NCT02583763)
- Testing
- Echocardiography, Blood sample
- Where
- 2 sites in Sweden
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping