Clinical trials: Heart; Complications
Dyspnea; Uremic, End Stage Renal Disease
Dyspnea Assessment in Hemodialysis Patients
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of…
- Conditions
- Dyspnea; Uremic, End Stage Renal Disease, Chronic Lung Disease, Chronic Heart Disease
- Trial name
- NCT03773991
- Testing
- Lung MRI, Sodium MRI, Chest CT
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Surgery, Acute Kidney Injury
Acute Normovolemic Hemodilution in Complex Cardiac Surgery
Postoperative bleeding in cardiac surgery is a frequent complication, and cardiac surgery utilizes 15-20% of the national blood supply. Packed red blood cells (pRBCs) are associated with worse short and long term outcomes.
- Conditions
- Cardiac Surgery, Acute Kidney Injury, Congenital Heart Disease, Aortic Surgery
- Trial name
- ANH (NCT05049590)
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of California, Los Angeles
Heart Diseases, Vascular Diseases
Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration…
- Conditions
- Heart Diseases, Vascular Diseases, Transfusion Related Complication, Coagulation Disorder, Blood
- Trial name
- NCT05806346
- Testing
- TXA administration
- Where
- 3 sites in South Korea
- Volunteers
- 764 people
- Sponsor
- Konkuk University Medical Center
Diabetes Mellitus, Type 2, Heart Failure
A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record
The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure.
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Chronic Kidney Diseases
- Trial name
- APPLE TREE (NCT06642272)
- Testing
- Empagliflozin 10 MG, Dapagliflozin 10 MG
- Where
- 12 sites in Denmark
- Volunteers
- 17,200 people
- Sponsor
- Herlev and Gentofte Hospital
Myocardial Reperfusion Injury
Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)
The use of volatile anesthetics in cardiac anesthesia is very common, because of their cardioprotective effects and their ability to ensure a sufficient depth of anesthesia.
- Trial name
- NCT01601795
- Testing
- Sevoflurane, Isoflurane
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Elderly Patients (>65 Years), Diabetes (DM)
Multidisciplinary Dissection of Renal and Metabolic Effects of Glyfozines on Elderly Patients: From Molecular Aspects to Clinical Indications
The project aims to study the impact of SGLT2i therapy on clinical and biochemical aspects. in elderly. The project will combine different types of data, such as clinical and biological information, and will use advanced Bayesian…
- Conditions
- Elderly Patients (>65 Years), Diabetes (DM), Heart Disease, Renal Diseases
- Trial name
- NCT07119424
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Chiara Lanzani
Atrial Fibrillation, Atrial Flutter
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2)
People receiving dialysis are more likely to develop atrial fibrillation (AF), an irregular heartbeat that increases the risk of stroke.
- Conditions
- Atrial Fibrillation, Atrial Flutter, End Stage Kidney Disease (ESRD), Dialysis Patients
- Trial name
- SAFE-D2 (NCT07779746)
- Testing
- Eliquis, No oral anticoagulation
- Volunteers
- 848 people
- Sponsor
- Unity Health Toronto
Major Non-cardiac Surgery
Effects of Perioperative Administration of Dexamethasone on Postoperative Complications and Mortality After Non-cardiac Major Surgery
Postoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery.
- Trial name
- PACMAN (NCT03218553)
- Testing
- Dexamethasone
- Where
- 29 sites in France
- Volunteers
- 1,222 people
- Sponsor
- Nantes University Hospital
Kidney Diseases
Shrunken Pore Syndrome: a Retrospective, Single Center, Cohort Study
To study the impact a difference in renal clearance of small and large molecules has on long-term survival.
- Trial name
- NCT04141072
- Testing
- Shrunken Pore Syndrome
- Where
- Sweden
- Volunteers
- 4,719 people
- Sponsor
- Henrik Bjursten
Turner Syndrome, Ovarian Insufficiency
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population.
- Trial name
- CRYO-X0 (NCT01410045)
- Testing
- Ovariectomy
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Delirium
The Delirium-CS Canada Study
Delirium is a prevalent complication following cardiac surgery that is under-recognized using current methods of delirium detection and that may be better identified through a systematic and standardized perioperative screening…
- Trial name
- DELIRIUM-CS (NCT02206880)
- Where
- 12 sites in Canada
- Volunteers
- 235 people
- Sponsor
- St. Boniface Hospital
Arrhythmia, Cardiac
Japanese Lead Extraction Registry
Japanese Lead Extraction (J-LEX) Registry is an observational nationwide registry, performed by Japanese Heart Rhythm Society, collaborated with the National Cerebral and Cardiovascular Center.
- Trial name
- J-LEX (NCT04345627)
- Where
- Japan
- Volunteers
- 5,000 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Acute Heart Failure, Renal Failure
Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure
Renal Compromise after treatment of decompensated heart failure with diuretics is not uncommon. The purpose of our study is to investigate the relationship between cystatin C and worsening renal function in this setting.
- Trial name
- NCT00561483
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Complication of Coronary Artery Bypass Graft
The Fusion Versus The Affinity Oxygenation Systems
This study compares between the clinical, hematological, inflammatory and neurological outcome of patients undergoing Coronary Artery Bypass Grafting (CABG) surgery in which different oxygenation systems will be used.
- Trial name
- NCT02554305
- Testing
- fusion oxygenation system, Affinity oxygenation system
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Pain, Postoperative
Serratus Planus Block After Minimally Invasive Cardiac Surgery
Many patients receiving MICS (minimally invasive cardiac surgery) suffer from significant postsurgical pain. While systemic analgesic therapy has been proven to be insufficient in a great number of patients, significant unwanted…
- Trial name
- NCT06746272
- Testing
- Serratus Anterior Plane Block
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- Medical University of Vienna
Acute Kidney Injury
Dexmedetomidine in Pediatric Cardiac Surgery
Dexmedetomidine is a selective α-2 receptor agonist with a sedative and cardiopulmonary profile that makes it an attractive anesthetic for pediatric patients with congenital heart disease (CHD).
- Trial name
- NCT02888275
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Seoul National University Hospital
Chronic Kidney Disease, Heart Failure With Reduced Ejection Fraction (HFrEF)
Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure
This study compares the effects of once-daily versus twice-daily ramipril dosing on renal function in chronic kidney disease (CKD) patients with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT07259512
- Testing
- Ramipril
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Evi Liliek Wulandari
Fetal Distress With Antenatal Problem, Fetal Growth Retardation
Validation of Sensors for Long-term Non-Invasive Fetal Monitoring
A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy.
- Trial name
- NCT06952777
- Testing
- Non-adhesive capacitively-coupled sensors
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
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