Clinical trials: Heart; Complications
Postoperative Complications
Cardiopulmonary Exercise Testing in Cardiosurgery Patients
Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery.
- Trial name
- NCT06702059
- Testing
- Cardiopulmonary exercise testing
- Where
- 2 sites in Czechia
- Volunteers
- 130 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Kidney Disease, Left Ventricular Hypertrophy
Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction?
Cardiovascular related disease is the main cause of death in patients with kidney disease, and "oxidative stress" is thought to be a major contributor by promoting thickening of the heart muscle and stiffening of the arteries.
- Trial name
- NCT00688480
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- A. D. Struthers
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Urinary Incontinence
Development of a Cardiac Signal Analysis Algorithm for Bladder Filling Assessment: Pilot Study
The puropose of this clinical trial is to build a database of signals issued from the device to delvelop signal processing algorithms to calculat the LFVI.
- Trial name
- ENURESIA 1 (NCT07607652)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Coronary Artery Disease, Vascular Access Complication
Left Radial comparEd to Femoral Approach for CORonary Angiography in Patients With Previous CABG StuDy
This randomized, multicenter, prospective study seeks to compare left radial and femoral access during cardiac catheterization of patients with prior history of CABG surgery, with the primary objective of demonstrating that the…
- Trial name
- L-RECORD (NCT03393052)
- Testing
- Coronary Angiography
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University Hospital of Patras
Drug Resistance, Bacterial, Postoperative Wound Infection
Local Collagen-Gentamicin and Extra Fixation of the Sternum for Prevention of Sternal Wound Infection in Cardiac Surgery
The aim of the present study is to evaluate a new technique for prevention of sternal wound infection consisting of local application of collagen-gentamicin in addition to routine i.v. antibiotic prophylaxis.
- Trial name
- LOGIX (NCT00484055)
- Testing
- Local application of collagen-gentamicin, Fixation of the sternotomy with more than six wires
- Where
- 2 sites in Sweden
- Volunteers
- 1,358 people
- Sponsor
- Region Örebro County
Accident, Traffic
Role of ETS in Improving Cardiac and Respiratory Complications in Road Traffic Accident Cases
This study will be a Cross-Sectional Study The research will be conducted in the Accident \& Emergency (A\&E) Department and Trauma Center of District Head Quarter (DHQ), Karak.
- Trial name
- NCT07049393
- Testing
- Road traffic accident (RTA) victims(SAQ)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Superior University
Postoperative Cognitive Dysfunction, Delirium
Correlation Between Urine UACR and Postoperative Neurocognitive Disorder in Elderly Patients With Non-cardiac Surgery
This study intends to evaluate the relationship between urinary albumin/creatinine ratio and postoperative neurocognitive impairment in elderly non-cardiac surgery patients.
- Trial name
- NCT03860714
- Testing
- Neuropsychological tests
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Han Yuan
Atrial Fibrillation, Peritoneal Dialysis Complication
Safety and Efficacy of Apixaban Versus Warfarin in Peritoneal Dialysis Patients With Non Valvular Atrial Fibrillation: a Prospective, Randomised, Open-label, Blinded End-point Trial (APIDP2)
Introduction: Several randomised controlled trials have demonstrated that novel oral anticoagulants (NOACs) are safer compared to vitamin K antagonists for the management of non valvular atrial fibrillation (NVAF) to prevent…
- Trial name
- APIDP2 (NCT06045858)
- Testing
- Anticoagulation Agents
- Volunteers
- 178 people
- Sponsor
- University Hospital, Caen
Myocardial Infarction, Reperfusion Injury
Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on…
- Trial name
- R²ACE (NCT01414452)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universiteit Antwerpen
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Vagus Nerve Stimulation, Acute Coronary Syndrome
Auricular Vagus Stimulation and STEMI
At the moment, the invasive strategy for the infarct-associated coronary artery in patients with ST-segment elevation myocardial infarction (STEMI) necessary to save the myocardium and reduce the size of the necrosis zone remains…
- Conditions
- Vagus Nerve Stimulation, Acute Coronary Syndrome, Ischemia Reperfusion Injury
- Trial name
- NCT05992259
- Testing
- TENS
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
End Stage Renal Disease, Cardiac Insufficiency
Invasive Monitoring of Pulmonary Artery Pressure (PAP) Among Dialysis Treated Patients
The purpose of this study is examine whether invasive pulmonary artery pressure (PAP) monitoring could be beneficial for the patients in dialysis treatment.
- Trial name
- NCT02862197
- Where
- Finland
- Volunteers
- 8 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
CMR in T2DM: The NSR Cohort
This study aims to investigate the myocardial phenotype of patients with type 2 diabetes. From 2016-2019 the investigators recruited a cohort of 296 subjects with type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies, Cardiovascular Magnetic Resonance Imaging, Coronary Microvascular Dysfunction
- Trial name
- NCT05915260
- Testing
- All subjects will undergo cardiac magnetic resonance imaging with gadolinium contrast and with adenosine myocardial perfusion
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Slagelse Hospital
Post Operative Pain, Bradycardia
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
Abdominal surgeries are major surgical procedures that are performed at any teaching hospital. Pain control is major concern in the intra-operative as well as post-operative period in these patients.
- Conditions
- Post Operative Pain, Bradycardia, Hypotension, Nausea
- Trial name
- NCT06531603
- Testing
- bupivacaine wound infilteration, Bupivacaine plus dexmedetomidine wound infilteration
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahiwal medical college sahiwal
Premature Birth, Newborn
Pain Management in Neonatal Intensive Care Units by Studying the Autonomic Balance
Fight against the pain caused by the disease or by the diagnostic and therapeutic procedures is a daily and essential concern for the caregiver neonatologist.
- Trial name
- NIPE-DOL (NCT02764424)
- Testing
- NIPE (MDoloris®)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation
TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics
The aim of this clinical study is to learn more about the effects of TAVR-prosthesis positioning on hemodynamics and the coronary arteries. The main questions it aims to answer are: 1.
- Conditions
- Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation, Commissural Alignment, Commissural Misalignment
- Trial name
- NCT06896227
- Testing
- transthoracic echocardiography
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hyperoxia
Hyperoxia and Pulmonary Complications After Cardiac Surgery
The main objective is to demonstrate that hyperoxia in cardiac surgery increase the occurrence of post-operative pulmonary complications
- Trial name
- HYPER-CARDIO (NCT04278066)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS)
Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis
The ASPIRE-GCA Pilot trial will assess the feasibility of a future randomized controlled trial (RCT) evaluating the efficacy of low-dose ASA in preventing ischemic complications in patients with Giant Cell Arteritis (GCA).
- Conditions
- Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS), Ishemic and Thrombotic Complications
- Trial name
- ASPIRE-GCA (NCT07908082)
- Testing
- Acetyl Salicylic Acid (ASA)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Cardiac Surgery
Effect of Stellate Ganglion Block on Arterial Catheterization Complications in Selected Group of Patients Undergoing Elective Cardiac Surgeries
Radial artery catheterization is the usual method for invasive monitoring in cardiac surgeries. Although it is relatively safe, complications do happen. Hematoma and ischemia are well known complications.
- Trial name
- stellate block (NCT07077824)
- Testing
- Stellate Ganglion Block Injection with Bupivicaine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
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