Clinical trials: Heart; Dysfunction Postoperative, Cardiac Surgery
Cardiac Surgery, Post-operative Cognitive Dysfunction
Active Temperature Management After Cardiac Surgery and Its Effect on Postoperative Cognitive Dysfunction
This study will assess the effect of active postoperative temperature management and its effect on the cognitive function in patients following coronary artery bypass graft (CABG) surgery to determine if active postoperative…
- Conditions
- Cardiac Surgery, Post-operative Cognitive Dysfunction, Fever
- Trial name
- NCT03947671
- Testing
- Rapr Rounds Hyper/Hypothermia Wraps, Acetaminophen
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Sepsis
Validation of Progranulin as a Biomarker for Sepsis
Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.
- Trial name
- PROGRANULIN (NCT03280576)
- Where
- 2 sites in Germany
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Organ Dysfunction, Inflammation in Cardiac Surgery
Epigenetic Susceptibility to Inflammatory Complications After Cardiac Surgery
This study aims to better understand 3 crucial questions: 1. Why do some patients experience more severe complications after heart surgery than others? 2.
- Conditions
- Organ Dysfunction, Inflammation in Cardiac Surgery, Epigenetic, Coronary Artery Bypass Graft
- Trial name
- Epi-SICCS (NCT07865026)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Glasgow
Heart; Dysfunction Postoperative, Cardiac Surgery
VolulyteTM in Cardiac Surgery
The study will compare the efficacy and safety of VolulyteTM and human albumin in elective open-heart surgery in adult patients.
- Trial name
- NCT01553617
- Testing
- 6% hydroxyethyl starch 130/0.4 in an isotonic electrolyte solution (VolulyteTM), Human serum albumin
- Where
- 5 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Fresenius Kabi
Intellectual Frailty of Aging, Cardiovascular Diseases
Assessment of Frailty as a Risk Factor for Cardiac and Vascular Surgery
The purpose of this study is to assess the impact of frailty as a multidimensional risk factor on the outcomes of adult cardiac and vascular surgery.
- Conditions
- Intellectual Frailty of Aging, Cardiovascular Diseases, Myocardial Infarction, Vascular Diseases
- Trial name
- NCT02224222
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Pulmonary Dysfunction, Median Sternotomy Recovery
FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy
Background and Rationale: Open-heart surgery via a median sternotomy is associated with severe acute postoperative pain. This pain can impair a patient's ability to take deep breaths and cough effectively which increases the risk…
- Conditions
- Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
- Trial name
- FROST-STERN (NCT07637370)
- Testing
- Intercostal Nerve Cryoablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Surgical Wound, Wound Healing Delayed
Using AI Within Digital Wound Monitoring of Surgical Wounds to Prioritise Non-healing Wounds for Urgent Review
The goal of this clinical trial is to learn if artificial intelligence within digital wound monitoring of surgical wounds can prioritise non-healing wounds for urgent review in patients having first/redo CABG surgeries with or…
- Conditions
- Surgical Wound, Wound Healing Delayed, Heart; Surgery, Heart, Functional Disturbance as Result
- Trial name
- WISDOM (NCT06475703)
- Testing
- Isla wound prioritisation module, Standard follow-up
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pain, Postoperative, Atrial Fibrillation
BRS and Outcomes in Cardiothoracic Surgery
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how likely you are to suffer…
- Conditions
- Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
- Trial name
- NCT03243279
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Delirium, Inflammation
The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery
The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on…
- Conditions
- Delirium, Inflammation, Cognitive Disorders, Amnestic
- Trial name
- KeCoDy (NCT02782429)
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Flavia orange
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery Requiring Extracorporeal Circulation
Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac Surgery
Cardiac Surgery and Acute Kidney Failure (AKI) post Surgery: AKI is a frequent complication in the immediate aftermath of cardiac surgery with an incidence varying from 5 to 40%.
- Trial name
- MIT-CEC (NCT04125069)
- Testing
- Coronary Artery Bypass Graft (CABG)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital Center of Martinique
Atrial Fibrillation, Left Ventricular Diastolic Dysfunction
Characterizing Patients With POAF in Relation to Cardiac Surgery by wavECG and TTE
Post-operative atrial fibrillation (POAF) is frequently observed after open-heart surgery. Despite numerous attempts to predict POAF, it remains a challenge to correctly identify the patients at risk.
- Trial name
- NCT03962166
- Where
- Denmark
- Volunteers
- 353 people
- Sponsor
- Helena DOMINGUEZ
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Heart Surgery
To determine the rate of Postoperative Cognitive Dysfunction (POCD) in the early and late postoperative periods by comparing the preop and postop period mini mental status tests in participants undergoing open heart surgery, and…
- Trial name
- NCT05406843
- Testing
- Preoperative cognitive functions of participants undergoing open heart surgery, Postoperative cognitive functions of particiants undergoing open heart surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kocaeli University
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Postoperative Cognitive Decline, Postoperative Delirium
Daridorexant to Prevent Post-cardiotomy Delirium
The goal of this follow-on pilot randomized clinical trial is to obtain additional preliminary data to inform a larger, adequately powered phase 2b trial of daridorexant for the prevention of postoperative delirium after heart…
- Trial name
- NCT07217912
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Head and Neck Surgery, Maxillofacial Surgery
Impact of Nociception Level (NOL)-Guided Remifentanil Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity
The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension…
- Trial name
- NCT04963036
- Testing
- Entropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Cognitive Function Abnormal, Anesthesia
Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations.
- Conditions
- Cognitive Function Abnormal, Anesthesia, Surgery
- Trial name
- NCT04101006
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Cognitive Disorder, Glaucoma
Application of Innovative Non-Invasive Neuroprotective Technology in Cardiac Surgery and Ophthalmology
Postoperative cognitive dysfunction (POCD) and delirium (incidence up to 42 %) after cardiac surgery with cardiopulmonary bypass (CPB) are common postoperative complications that impair the patient's quality of life and increase…
- Trial name
- NCT04943458
- Testing
- Monitoring of cerebral autoregulation
- Where
- Lithuania
- Volunteers
- 270 people
- Sponsor
- Milda Svagzdiene
Surgical Wound Infection, Heart; Surgery, Heart, Functional Disturbance as Result
Early Detection of Surgical Wound Infections Using Sensor Technology
Infections that are caused by surgical incision are commonly known as surgical site infections (SSI). A surgical wound infection can develop at any time after surgery until the wound has healed (usually two to three weeks after…
- Trial name
- SSI-Sensor (NCT03401658)
- Testing
- Sensor light detector
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Pulmonary Atelectasis
Descriptive and Comparative Study of Respiratory Function in the Postoperative Cardiac Surgery Patient
The study comprises two different objectives. Longitudinal description of postoperative pulmonary dysfunction in the cardiothoracic surgery patient, and the comparison of two different lungrecruitment strategies.
- Trial name
- NCT03009331
- Testing
- Lungrecruitment manoeuver in prone position., Lungrecruitment manoeuver in supine position.
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital