Clinical trials: Heart; Dysfunction Postoperative, Cardiac Surgery
Heart; Dysfunction Postoperative, Cardiac Surgery, Anemia, Iron-Deficiency
Pre-operative Treatment With Erythropoietin and Iron Supplement in Cardiac Surgery
Pre-treatment of patients with erythropoietin subcutaneously and iron supplement intravenously, in order to create a clinical pathway to minimize transfusion of red blood cells in a selected group of cardiac patients with an…
- Trial name
- NCT02210949
- Testing
- Erythropoietin subcutaneously and Iron intravenously
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Postoperative Cognitive Dysfunction, Postoperative Recovery
Older People's Neurocognitive Recovery After Cardiac Surgery
Society is aging and advantages in anesthesia and surgery allow more complex interventions in older persons. Old age is a significant risk factor for the development of postoperative neurocognitive decline characterized by a…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Recovery, Cardiac Surgery
- Trial name
- ECPON (NCT06469515)
- Testing
- Elective or urgent cardiac surgery
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Karolinska Institutet
Cardiac Surgery and Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery
Many patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00334191
- Testing
- Sodium Bicarbonate
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Austin Health
Postoperative Cognitive Dysfunction(POCD)
The Effect and Mechanism of Computerized Cognition Training on the Incidence of Postoperative Cognitive Dysfunction After Cardiac Surgery
Whether enough time and high-quality cognitive training will reduce the incidence of postoperative cognitive dysfunction after cardiac surgery.
- Trial name
- NCT05523258
- Testing
- Computerized cognition training, Basic training based on tablet computer
- Volunteers
- 174 people
- Sponsor
- Mu Dong Liang
Heart; Dysfunction Postoperative, Cardiac Surgery, Adverse Anesthesia Outcome
The Prognostic Value of Troponin T for Long-term Outcome After Cardiac Surgery
This survey has two aims. First, we would like to be informed about the health condition of our patients two years following heart surgery at University Hospital, Basel.
- Trial name
- NCT00468598
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiac Disease, Myocardial Dysfunction
Temporary Epicardial Pace Wire With Integrated Sensor for Continuous Postoperative Monitoring of Myocardial Function
Transesophageal echocardiography is used to monitor cardiac wall motion at various time points during open-heart surgery. After surgery, the measurements are made at various time points by transthoracic echocardiography.
- Trial name
- NCT04886934
- Testing
- CS1 System
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Cardiaccs AS
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Patients Undergoing Cardiac Surgery
The Relation Between Preoperative ScO2 and the Postoperative Course of Humoral Organ Dysfunction Markers.
Cerebral oxygen saturation (ScO2) is a measure of cerebral and systemic oxygen delivery to demand ratio. An observational trial in a heterogeneous cohort of 1078 patients patients revealed that a ScO2 below 50% absolute during…
- Trial name
- NCT01409941
- Volunteers
- 765 people
- Sponsor
- University of Luebeck
Postoperative Complications
Cardiac Surgery and Postoperative Organ Dysfunction
The aim of the study is to identify the correlation between ischaemia reperfusion injury and postoperative multiorgan damage during cardiopulmonary cardiac surgery; and to investigate biomarkers that can predict postoperative…
- Trial name
- NCT05529212
- Testing
- ischemic reperfusion injury
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Surgery, Postoperative Cognitive Dysfunction
Five Years Follow-up of Neurological Outcome After Minimally Invasive Cardiac Surgery
A monocenter observational study will be started to investigate postoperative cognitive dysfunction 5 years after minimally invasive cardiac surgery.
- Trial name
- FUNOMICS (NCT05330260)
- Testing
- neurocognitive test battery
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Postoperative Cognitive Dysfunction
Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery
Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of…
- Trial name
- NCT04679259
- Testing
- Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood, Neurocognitive test, Assessment of delirium
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- SMG-SNU Boramae Medical Center
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Efferon LPS Hemoadsorption in Cardiac Surgery Patients
This randomized controlled study aims to evaluate the efficacy and safety of intraoperative and early postoperative hemoadsorption using the Efferon® LPS device in patients undergoing cardiac surgery with cardiopulmonary bypass…
- Trial name
- NCT07532174
- Testing
- Efferon LPS
- Where
- 3 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes
To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for…
- Trial name
- NCT02992600
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Han Yuan
Postoperative Cognitive Complications, Open Heart Surgery
Effect of a Cooling Helmet on Postoperative Cognitive Dysfunction in Adults Undergoing Open-Heart Surgery
Postoperative cognitive dysfunction, or POCD, is a decline in thinking, memory, attention, or executive function that may occur after surgery and anesthesia.
- Trial name
- HELMET-POCD (NCT07689500)
- Testing
- Cooling Helmet With Cold Water Circulation, Cooling Helmet With Room-Temperature Water Circulation
- Where
- Indonesia
- Volunteers
- 153 people
- Sponsor
- Universitas Indonesia
Post Operative Cognitive Dysfunction
Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients
This study will recruit patients more than 65 years old eligible for non-cardiac surgery. Patients who participate will take either vitamin B12 and folic acid supplementation or placebo for 7 days before surgery.
- Trial name
- B12-POCD (NCT03485404)
- Testing
- methylcobalamin, Folic Acid, non-cardiac surgery
- Where
- 13 sites in China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Postoperative Cognitive Dysfunction
Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery
Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life.
- Trial name
- NCT07681063
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Delirium, Cognitive Decline
Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery
Increasing numbers of elderly patients are undergoing cardiac surgery. Elderly patients may have prolonged recovery following cardiac surgery when compared to other groups of patients, and are at higher risk of postoperative…
- Conditions
- Delirium, Cognitive Decline, Post-operative Quality of Recovery
- Trial name
- DIRECT (NCT02699801)
- Testing
- propofol, Dexmedetomidine
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of British Columbia