Clinical trials: Heart; Dysfunction Postoperative, Cardiac Surgery
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
A condition of decreased serum T3 level in children after cardiac surgery using cardiopulmonary bypass has been commonly recognized as euthyroid sick syndrome (ESS).
- Trial name
- OTICC (NCT02521168)
- Testing
- Oral triiodothyronine
- Where
- Indonesia
- Volunteers
- 177 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Postoperative; Dysfunction Following Cardiac Surgery
Stress, Anxiety and Type A Personality and Analgesics
Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests.
- Trial name
- SATA-1 (NCT02756598)
- Testing
- Sufentanil I, Sufentanil II, Propofol I
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Head and Neck Surgery, Maxillofacial Surgery
Impact of Nociception Level (NOL)-Guided Remifentanil Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity
The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension…
- Trial name
- NCT04963036
- Testing
- Entropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Cardiac Surgery, Post-operative Cognitive Dysfunction
Active Temperature Management After Cardiac Surgery and Its Effect on Postoperative Cognitive Dysfunction
This study will assess the effect of active postoperative temperature management and its effect on the cognitive function in patients following coronary artery bypass graft (CABG) surgery to determine if active postoperative…
- Conditions
- Cardiac Surgery, Post-operative Cognitive Dysfunction, Fever
- Trial name
- NCT03947671
- Testing
- Rapr Rounds Hyper/Hypothermia Wraps, Acetaminophen
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Feasibility of a Meditation Program Perioperatively
Guided Meditation as an Adjunct to Enhance Postoperative Recovery
The primary purpose of this trial is to test the feasibility of implementing a meditation program in the perioperative period.
- Trial name
- NCT03198039
- Testing
- Meditation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colectomy, Colectomy Left/Right/Total Under Laparotomy
Clinical Study on the Prevention and Treatment of Postoperative Gastrointestinal Dysfunction by Acupuncture Under ERAS Management Based on Artificial Intelligence Monitoring
Brief Summary: Acupuncture for Faster Recovery After Colorectal Surgery 1. What is this study about? Colorectal cancer is a common health condition that usually requires surgery.
- Conditions
- Colectomy, Colectomy Left/Right/Total Under Laparotomy, Cancer, Chinese Medicine
- Trial name
- NCT07335237
- Testing
- Accupuncture
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Valvular Heart Disease Patients
The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery
Ischemic reperfusion injury of cardiopulmonary bypass and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing valvular heart surgery.
- Trial name
- NCT02720549
- Testing
- remote ischemic postconditioning, valvular surgery with bypass
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Yonsei University
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Ischemic Heart Disease, Bone Marrow Cells
Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease
The purpose of this study evaluate the effect of the method of administration of autologous bone marrow mononuclear cells for the duration of of functioning aorto-coronary bypass grafts in the surgical treatment of coronary heart…
- Conditions
- Ischemic Heart Disease, Bone Marrow Cells, Coronary Artery Bypass Grafting (CABG), Heart Failure, Diastolic
- Trial name
- TAMIS (NCT02059512)
- Testing
- Group 1, Group 0, Group 2
- Where
- Russia
- Volunteers
- 117 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Heart; Dysfunction Postoperative, Cardiac Surgery
Clinical Assessment of Nonin 7600 Near Infrared Spectroscopy (NIRS) Tissue Oximetry During Cardiovascular Surgery
An observational study designed to evaluate the performance of a new Near Infrared Spectroscopy (NIRS) tissue oximeter device in the clinical setting, including a cerebral sensor and peripheral sensor.
- Trial name
- NCT01289470
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nonin Medical, Inc
Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and…
- Trial name
- NCT07483151
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POCD assessments
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhuan Zhang
Surgery
Role of Cerebral Oximetry in Reducing Postoperative End Organ Dysfunction/Failure After Complex Non-Cardiac Surgery
The number of elderly patients requiring general anesthesia for major surgical procedures is increasing dramatically. It is estimated that 20% of these patients will develop major complications after surgery.
- Trial name
- NCT04627506
- Testing
- Bilateral NIRS (Masimo, O3TM Regional Oximetry)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Prosthesis Survival, Prosthesis; Cardiac, Heart, Functional Disturbance as Result
Transcatheter Aortic Valve Implantation Versus Standard Surgical Aortic Valve Replacement
The mechanical intervention is treating aortic valve stenosis (AVS) which may be performed using the standard open surgical approach for aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI).
- Trial name
- TAVISAR (NCT05261204)
- Testing
- Transcatheter Aortic Valve Implantation, Bioprothesis, Sutureless
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Centre Cardiologique du Nord
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction
Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.
Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery.
- Conditions
- Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction, Mechanical Ventilation Strategies
- Trial name
- APRV-OBESE-CS (NCT07409324)
- Testing
- Airway Pressure Release Ventilation (APRV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Heart; Dysfunction Postoperative, Cardiac Surgery
VolulyteTM in Cardiac Surgery
The study will compare the efficacy and safety of VolulyteTM and human albumin in elective open-heart surgery in adult patients.
- Trial name
- NCT01553617
- Testing
- 6% hydroxyethyl starch 130/0.4 in an isotonic electrolyte solution (VolulyteTM), Human serum albumin
- Where
- 5 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Fresenius Kabi
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Cardiac Surgery and Cardiopulmonary Bypass
High-Dose N-Acetylcysteine in Cardiac Surgery
At least 14% of patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00332631
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Austin Health