Clinical trials: Heart Arrest, Out-Of-Hospital
Pediatric ALL, Cardiac Arrest
Effect of IAM With an I-gel® on Ventilation Parameters in Simulated Pediatric OHCA
Pediatric cardiac arrest occurs most in the prehospital setting. Most of them are due to respiratory failure (e.g., trauma, drowning, respiratory distress), where hypoxia leads to cardiac arrest.
- Conditions
- Pediatric ALL, Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation
- Trial name
- NCT05498402
- Testing
- i-gel ® device, bag-valve-mask ventilation
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Out-of-Hospital Cardiac Arrest
A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest
The objective of this study will be to assess the frequency of return of spontaneous circulation (ROSC), survival to admission, survival to discharge from the hospital, and neurologic function at time of discharge from the…
- Trial name
- NCT01413399
- Testing
- 4 degree chilled saline
- Where
- United States
- Volunteers
- 542 people
- Sponsor
- Wake Forest University Health Sciences
Out-of-Hospital Cardiac Arrest
Arizona Prehospital CPR Quality Improvement Project
The quality of cardiopulmonary resuscitation (CPR) provided to patients with out-of-hospital cardiac arrest (OHCA) is often suboptimal.
- Trial name
- NCT01258244
- Testing
- Audiovisual Feedback
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Valleywise Health
Out-of-hospital Cardiac Arrest
Cardiac AResT And GENEtic
Sudden death is a major problem in industrially developed countries. Despite a decline in ischemic heart disease mortality and the progress has been made in resuscitation, treatment of sudden death victims is frequently…
- Trial name
- CARTAGENE (NCT00604149)
- Where
- France
- Volunteers
- 2,332 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Out of Hospital Cardiac Arrest, Ventricular Fibrillation
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR
- Trial name
- DOUBLE D (NCT07174986)
- Testing
- Double sequential defibirllation, Standard defibrillation
- Where
- 14 sites in Netherlands, Spain and 1 more
- Volunteers
- 916 people
- Sponsor
- Gabriel Riva
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Out-of-Hospital Cardiac Arrest
AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA
The investigators aimed to evaluate the effect of AMCPR (Augmented-Medication CardioPulmonary Resuscitation: administration of additional vasopressin to titrate to arterial diastolic blood pressure over 20 mmHg) on…
- Trial name
- NCT03191240
- Testing
- Vasopressins, Normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- Asan Medical Center
Cardiac Arrest
Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
This trial is currently a single-center, randomized, double-blind investigator initiated prospective clinical trial initiated at the University of Ottawa Heart Institute (UOHI).
- Trial name
- CAPITALCHILL (NCT02011568)
- Testing
- Therapeutic Hypothermia
- Where
- Canada
- Volunteers
- 389 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Blood Pressure and Cerebral Blood Flow After Cardiac Arrest
Comatose patients that are admitted to an intensive care unit after out-of-hospital cardiac arrest (OCHA) have a high mortality, particularly due to hypoxic-ischemic neurologic injury.
- Trial name
- NCT05434910
- Testing
- Changes in mean arterial pressure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Niels Damkjær Olesen
Out-of-Hospital Cardiac Arrest
Implementation of Gold Standard EMS CPR Programs for 2% Improvement in Survival Rates of Out-of-Hospital Cardiac Arrest in a Metropolitan City
This study aims to improve the survival rate of out-of-hospital cardiac arrest patients by 2% through a bundle of three intervention measures including: 1) dispatcher-assisted CPR, 2) multi-tiered response team CPR, and 3)…
- Trial name
- 2% Project (NCT02540629)
- Testing
- Bundled EMS CPR approach including dispatcher-assisted CPR, 3-person team CPR, and feedback CPR monitoring device
- Where
- South Korea
- Volunteers
- 12,670 people
- Sponsor
- Seoul National University Hospital
Injury
Better First Aid With First Aid Training and Dispatcher Central Instructions?
The study evaluates the effect of a first aid course on first aid skills compared to no training. The study also evaluates the effect of first-aid instructions given by emergency dispatch central over mobile phone on first aid…
- Trial name
- NCT02391922
- Testing
- First aid course, First aid instructions by mobile phone
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tromso
Out-of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
Improving Bystander CPR Quality Through Dispatcher-assisted Basic Life Support Education Program
In an attempt to enhance OHCA survival by increasing bystander CPR rate, this study will assess the effectiveness of the new basic life support with dispatch assistance (DA-BLS) education program through a simulation experiment.
- Trial name
- NCT02527473
- Testing
- Dispatcher-Assisted Basic Life Support CPR Education
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Bystander, Chest Compression
REsuscitation Survey of Police Officers in New Taipei City for Duty
Out-of-hospital cardiac arrest (OHCA) remains a time-critical emergency where early cardiopulmonary resuscitation (CPR) and timely defibrillation using an automated external defibrillator (AED) are key to improving survival and…
- Conditions
- Bystander, Chest Compression, Out of Hospital Cardiac Arrest, AED
- Trial name
- RESPOND (NCT06955351)
- Testing
- Survey by Questionnaire
- Where
- Taiwan
- Volunteers
- 4,867 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Out-Of-Hospital Cardiac Arrest, Acute Coronary Syndrome
Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI
The main objective of the trial is to find out if 4-hour continuous infusion of parenteral P2Y12 inhibitor cangrelor at the start of primary percutaneous coronary intervention (PCI) immediately and effectively suppresses platelet…
- Trial name
- Cangrelor OHCA (NCT04005729)
- Testing
- Cangrelor 50 MG
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Wounds and Injuries, Out-of-Hospital Cardiac Arrest
Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest
This retrospective population-based cohort study uses linked administrative healthcare data from the Local Health Authority of Bologna (Italy) to describe the use of four classes of psychoactive drugs (opioids, antiepileptics…
- Conditions
- Wounds and Injuries, Out-of-Hospital Cardiac Arrest, Traumatic Brain Injury
- Trial name
- LIFT-C (NCT07882589)
- Testing
- Opioids (ATC N02A), Antiepileptics (ATC N03A), Antipsychotics (ATC N05A)
- Where
- 2 sites in Italy
- Volunteers
- 52,720 people
- Sponsor
- Azienda Usl di Bologna
Cardiac Arrest, Neurological Injury
Lactate in Cardiac Arrest
Blood lactate levels will be measured using a simple handheld device at time of return of spontaneous circulation (ROSC) following out of hospital cardiac arrest (OHCA).
- Trial name
- NCT02352350
- Testing
- Blood Lactate Levels, Neurological Outcomes
- Sponsor
- University of Florida
Heart Arrest, Out-Of-Hospital, Physical Activity
Physical Activity After Cardiac Arrest; a Sub-study in the Target Temperature Management Trial 2
The Target Temperature Management trial 2 (TTM2) is an international multi-center study, that randomize patients with OHCA of a presumed cardiac or unknown cause to target temperature management at 33°C or normothermia but…
- Trial name
- NCT03543332
- Testing
- Measures of physical activity and kinesiophobia
- Where
- 8 sites in Denmark, Sweden and 1 more
- Volunteers
- 109 people
- Sponsor
- Region Skane
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
AutoPulse Compared With Manual Technique for OHCA Patients on Outcome and CPR Process.
The AutoPulse Resuscitation System Model 100 (ZOLL Medical Corporation, Chelmsford, MA, US) ZOLL has been used as a standard treatment for a number of subjects in this trial and granted CE marking for Europe in November of 2003.
- Trial name
- NCT04663009
- Testing
- AutoPulse
- Where
- Norway
- Volunteers
- 3,250 people
- Sponsor
- Lars Wik
Cardiopulmonary Resuscitation, Echocardiography
Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound
Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR.
- Trial name
- NCT03852225
- Testing
- Intra-arrest echocardiography
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Emergency Medical Service of the Central Bohemian Region, Czech Republic
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA