Clinical trials: Heart Arrest, Out-Of-Hospital
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Blood Pressure and Cerebral Blood Flow After Cardiac Arrest
Comatose patients that are admitted to an intensive care unit after out-of-hospital cardiac arrest (OCHA) have a high mortality, particularly due to hypoxic-ischemic neurologic injury.
- Trial name
- NCT05434910
- Testing
- Changes in mean arterial pressure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Niels Damkjær Olesen
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk
Out-of Hospital Cardiac Arrest
Hyperinvasive Approach in Cardiac Arrest
Prague out-of Hospital Cardiac Arrest (OHCA) study is a prospective randomized multicenter clinical study comparing use of prehospital intraarrest hypothermia, mechanical chest compression device, extracorporeal life support…
- Trial name
- NCT01511666
- Testing
- Prehospital mechanical compressions, intraarrest cooling and in hospital ECLS, Standard care
- Where
- Czechia
- Volunteers
- 256 people
- Sponsor
- Charles University, Czech Republic
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Cardiac Arrest, Out-Of-Hospital, Cardiac Arrest With Successful Resuscitation
CardioPulmonary Resuscitation With Argon (CPAr) Trial
Preclinical studies suggest that argon (Ar) might diminish the neurological and myocardial damage after any hypoxic-ischemic insult.
- Trial name
- CPAr (NCT05482945)
- Testing
- Noble gas Argon
- Where
- 9 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Heart Arrest
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) is an important issue for the emergency physicians and co-workers. How to improve the return of spontaneous circulation (ROSC) rate and prognosis of these patients challenges the emergency…
- Trial name
- NCT00172354
- Testing
- Hydrocortisone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Out-Of-Hospital Cardiac Arrest
The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries
Objectives/Hypotheses 1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites.
- Trial name
- NCT05545176
- Testing
- termination of resuscitation rules
- Where
- Taiwan
- Volunteers
- 140,000 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest, Coma
Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades
New single use laryngoscope metal blades are available for intubation. This type of blade is safer than the reusable ones concerning the interhuman cross infection risk.
- Conditions
- Cardiac Arrest, Coma, Major Trauma, Respiratory Distress
- Trial name
- LAMETA (NCT00644722)
- Testing
- MacIntosh Green Lite (metal single use laryngoscope blades), MacIntosh Green Spec II (metal reusable laryngoscope blades)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Henri Mondor University Hospital
Cardiac Arrest, Cardiac Arrest Circulatory
Resuscitative TEE Collaborative Registry
The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and…
- Conditions
- Cardiac Arrest, Cardiac Arrest Circulatory, Cardiac Arrest, Out-Of-Hospital, Shock
- Trial name
- rTEECoRe (NCT04972526)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Out-of-hospital Cardiac Arrest (OHCA), Cardiac Arrest (CA)
the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)
Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiac Arrest (CA), CPR, ACLS
- Trial name
- Bio-CPR (NCT07258823)
- Testing
- CPR
- Volunteers
- 408 people
- Sponsor
- Guangdong Provincial People's Hospital
Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR)
The AIR-CPR Study: AI-Guided Chest Compressions
The AIR-CPR project aims to improve survival rates for patients with Out-of-Hospital Cardiac Arrest (OHCA) by utilizing Artificial Intelligence (AI) to optimize chest compression locations.
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR), Aortic Valve Compression, Precision Resuscitation
- Trial name
- AIR-CPR (NCT07431710)
- Testing
- Device: AI-Enhanced Arterial Waveform Monitor (AIR-CPR App), AI-Guided Chest Compression Repositioning, Transesophageal Echocardiography (TEE)
- Where
- Taiwan
- Volunteers
- 255 people
- Sponsor
- Far Eastern Memorial Hospital
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiac Arrest With Successful Resuscitation, Post Cardiac Arrest Syndrome
- Trial name
- STEROHCA (NCT04624776)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 2 sites in Denmark
- Volunteers
- 158 people
- Sponsor
- Christian Hassager
Out-Of-Hospital Cardiac Arrest
Referral of Callers to Retrieve Drone-delivered AEDs in Out-of-hospital Cardiac Arrest
Time to defibrillation is the most important predictor of survival in cardiac arrest. Recent studies have shown that unmanned drones can deliver AEDs to the site of real life out-of hospital cardiac arrest (OHCA) before ambulance…
- Trial name
- NCT05391256
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- 2 sites in Sweden
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest
More than 300,000 Americans experience out-of-hospital cardiac arrest annually, with overall survival rates averaging less than 5%.
- Trial name
- NCT01325870
- Testing
- ACD-CPR, ITPR, S-CPR
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Advanced Circulatory Systems
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Sudden
The Scandinavian AED and Mobile Bystander Activation Trial
Sudden cardiac death is a major health problem in the western world. In Europe alone nearly 300 000 patients are affected annually.
- Trial name
- SAMBA (NCT02992873)
- Testing
- Layperson allocated to start CPR and fetch nearest AED, Layperson allocated to start CPR
- Where
- 2 sites in Sweden
- Volunteers
- 815 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Do Patients Suffering a Cardiac Arrest Present to the Ambulance Service With Symptoms in the Preceeding 48hrs?
A cardiac arrest is often preceeded by a varying period of physiological deterioration which if acted upon may prevent the cardiac arrest.
- Trial name
- NCT04604639
- Testing
- NEWS2 score
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Prehospital Airway Management in Patients With Cardiac Arrest
A RCT on Supraglottic Airway Versus Endotracheal Intubation in OHCA
In this 3-year successive research plan, investigators will conduct a prehospital randomized controlled trial to address the following question: In adult patients with non-traumatic cause of out-of-hospital cardiac arrest…
- Trial name
- SAVE (NCT02967952)
- Testing
- supraglottic airway (SGA) V.S. endotracheal intubation (ETI)
- Volunteers
- 852 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have…
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Emergency Medical Services
- Trial name
- REVIVES (NCT06203847)
- Testing
- Combination group, Standard group
- Where
- Taiwan
- Volunteers
- 1,344 people
- Sponsor
- National Taiwan University Hospital
Pediatric, Cardiac Arrest
Pediatric Out-of-hospital Cardiopulmonary Arrest
The objective of this observational and retrospective study is to determine the predictive factors of in-hospital mortality following an out-of-hospital cardiopulmonary arrest (CPA) in the population under 18 years old.
- Conditions
- Pediatric, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
- Trial name
- Ped-CPA (NCT05474131)
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Ischemic Brain Injury
Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients
The main purpose of this study is to explore whether xenon is neuroprotective in humans. In addition, the purpose is to explore the underlying mechanisms for the possible synergistic neuroprotective interaction of xenon and…
- Trial name
- Xe-hypotheca (NCT00879892)
- Testing
- xenon, Hypothermia
- Where
- 10 sites in United States, Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital