Clinical trials: Heart Arrest, Out-Of-Hospital
Cardiac Arrest Due to Trauma (Disorder)
Ultrasound-guidance for Intraosseous Access During Earthquake
The aim of this field report is to describe as the use ultrasound guidance can facilitate the insertion of intraosseous access, during the resuscitation, in the victims of out-of hospital traumatic cardiac arrest
- Trial name
- NCT03491787
- Testing
- Ultrasound guidance
- Volunteers
- 31 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Out of Hospital Cardiac Arrest
Developing a Digital Handover Application for Paramedics to Provide a Personalized Approach to Pre-hospital Stratification for Out of Hospital Cardiac Arrest
A prospective study validating the role of the MIRACLE2 score in patients with resuscitated out of hospital cardiac arrest in a pre-hospital setting.
- Trial name
- RAPID-MIRACLE (NCT05185063)
- Testing
- Point of Care blood test
- Volunteers
- 500 people
- Sponsor
- King's College London
Cardiac Arrest, Trauma
Pre-Hospital Advanced Airway Management in the Nordic Countries
Pre-Hospital Advanced Airway Management (PHAAM) is a potentially lifesaving intervention. A recent Danish multicentre single country study demonstrated a 99,7% incidence of successful anaesthesiologist pre-hospital endotracheal…
- Conditions
- Cardiac Arrest, Trauma, Traumatic Brain Injury, Hypoventilation
- Trial name
- PHAST (NCT02450071)
- Where
- Sweden
- Volunteers
- 2,028 people
- Sponsor
- Karolinska Institutet
Out-of-Hospital Cardiac Arrest, Blood Pressure
Blood Pressure and OXygenation Targets After OHCA
This study compares two blood pressure targets and two oxygenation targets in the post-resuscitation care of comatose out-of-hospital cardiac arrets patients.
- Conditions
- Out-of-Hospital Cardiac Arrest, Blood Pressure, Hemodynamic Instability
- Trial name
- BOX (NCT03141099)
- Testing
- Low normal MAP, High normal MAP, Low normal PaO2.
- Where
- 2 sites in Denmark
- Volunteers
- 802 people
- Sponsor
- Jesper Kjaergaard
Arrest Cardio Respiratory
Free Iron and Out of Hospital Cardiac Arrest
Out of hospital cardiac arrest is associated with a poor prognosis. The aim of this study is to provide a better understanding of perturbations of iron metabolism after cardiac arrest and to analyze the impact on clinical…
- Trial name
- DESFER (NCT03491670)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Brest
Early Aspiration Pneumonia
Bronchial Alpha Amylase as a Marker for Early Aspiration Pneumonia in Therapeutic Hypothermia.
Early Aspiration Pneumonia is a frequent and dreadful complication in survivors of cardiac arrest. Therapeutic Hypothermia widely used in Intensive Care Unit for its benefice on post cardiac arrest syndrome may otherwise hide…
- Trial name
- NCT03007862
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Injury
Better First Aid With First Aid Training and Dispatcher Central Instructions?
The study evaluates the effect of a first aid course on first aid skills compared to no training. The study also evaluates the effect of first-aid instructions given by emergency dispatch central over mobile phone on first aid…
- Trial name
- NCT02391922
- Testing
- First aid course, First aid instructions by mobile phone
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tromso
Cardiac Arrest
Systems Saving Lives - Long-term Survival of Out-of-hospital Cardiac Arrest in the Urban Area of Bologna
Evaluation of clinical, logistical, and technical factors (e.g. implementation of pre-arrival instructions, implementation of the DAE RespondER, mechanical chest compressor, REBOA, and E-CPR) that impact on the outcomes of…
- Trial name
- SSL (NCT04510480)
- Testing
- Observational study without specific intervention
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Azienda Usl di Bologna
Out-Of-Hospital Cardiac Arrest
Accuracy of EEG Slow Wave Activity in Predicting Favourable Outcome in Patients With Hypoxic Brain Injury - A Substudy of STEPCARE Trial
This is an observational substudy embedded in the STEPCARE Trial. The study involves EEG analysis, covered by the ethics approval of STEPCARE Trial.
- Trial name
- PROPEASTEPCARE (NCT06564675)
- Testing
- C-Trend Index
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 300 people
- Sponsor
- University of Helsinki
Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia
Core Temperature in Patients With OHCA
A prospective observational study aiming to monitor core temperature via an esophageal probe in out of hospital cardiac arrest during transport and until arrival in hospital.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Accidental Hypothermia, Temperature Change, Body
- Trial name
- CT-OCHA (NCT04976712)
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- Azienda Sanitaria dell'Alto Adige
Out-of-Hospital Cardiac Arrest
A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest
The objective of this study will be to assess the frequency of return of spontaneous circulation (ROSC), survival to admission, survival to discharge from the hospital, and neurologic function at time of discharge from the…
- Trial name
- NCT01413399
- Testing
- 4 degree chilled saline
- Where
- United States
- Volunteers
- 542 people
- Sponsor
- Wake Forest University Health Sciences
Heart Arrest
rEduction of oXygen After Cardiac arresT: a Pilot Study
This Phase 2 study aims to determine the feasibility of paramedic titration of oxygen delivery in adult patients who have been resuscitated from OHCA.
- Trial name
- EXACT (NCT02499042)
- Testing
- Oxygen
- Where
- 2 sites in Australia
- Volunteers
- 59 people
- Sponsor
- Monash University
Out-of-hospital Cardiac Arrest
Prehospital Resuscitation Intra Nasal Cooling Effectiveness Survival Study
Promising result of intra-arrest cooling on neurological intact survival in cardiac arrest patients has recently been published in the PRINCE-study in Circulation 2010.
- Trial name
- PRINCESS (NCT01400373)
- Testing
- Prehospital intra-nasal cooling with RhinoChill
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 700 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Epidemiology and Cost-effectiveness of Out-Of-Hospital Cardiac Arrest in Finland
Observational study of all out-of-hospital cardiac arrest during 6 months in regional areas of Helsinki University Hospital and Kuopio University Hospital from activation of EMS system until follow up to 6 months of…
- Trial name
- FINNRESUSCI (NCT01295424)
- Testing
- No intervention
- Where
- Finland
- Volunteers
- 2,600 people
- Sponsor
- Kuopio University Hospital
Cardiac Arrest (CA)
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families
The aims are to define the exact prevalence of hereditary heart diseases in out-of-hospital cardiac arrest (OHCA) patients taking also into account gender, patient and OHCA characteristics, provincial settings and environmental…
- Trial name
- GenetiCA (NCT06844851)
- Where
- Italy
- Volunteers
- 1,725 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiac Arrest, Acute Coronary Lesion
Sensitive Troponin I in Out-of-hospital Cardiac Arrest
Troponin is a major diagnostic criterion of acute myocardial infarction (AMI) which confirms myocardial damage and necrosis. In out-of-hospital cardiac arrest (OHCA) patients its dynamics and diagnostic value is often…
- Conditions
- Cardiac Arrest, Acute Coronary Lesion, Stable Obstructive Coronary Disease, Non-obstructive Coronary Disease
- Trial name
- NCT02713048
- Testing
- Blood sample collection
- Where
- Slovenia
- Volunteers
- 159 people
- Sponsor
- University Medical Centre Ljubljana
Heart Arrest, Cardiac Arrest
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest.
- Trial name
- NCT01968148
- Where
- 2 sites in Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Out-of-hospital Cardiac Arrest
Digestive ENdoscopy afTeR Out-of-hospitAl Cardiac arresT
Post-cardiac arrest ischemia/reperfusion phenomenon led to organs injury and failure. Among the different organs, gastro-intestinal tract injury could contribute to post-cardiac arrest shock.
- Trial name
- ENTRACT (NCT02349074)
- Testing
- Digestive endoscopy
- Where
- 9 sites in Belgium, France
- Volunteers
- 221 people
- Sponsor
- Versailles Hospital
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital