Clinical trials: Heart Arrest, Out-Of-Hospital
Out-of-Hospital Cardiac Arrest
Survival Study After Out-of-hospital Cardiac Arrest
The purpose of this study is to determine if dual dispatch of ambulance, fire fighters and/or police in out-of-hospital cardiac arrest (OHCA), can reduce the time to cardiopulmonary resuscitation (CPR) and defibrillation, thus…
- Trial name
- SAMS (NCT02184468)
- Testing
- Simultaneously dispatch of firefighters and/or police in case of OHCA
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Epidemiology and Cost-effectiveness of Out-Of-Hospital Cardiac Arrest in Finland
Observational study of all out-of-hospital cardiac arrest during 6 months in regional areas of Helsinki University Hospital and Kuopio University Hospital from activation of EMS system until follow up to 6 months of…
- Trial name
- FINNRESUSCI (NCT01295424)
- Testing
- No intervention
- Where
- Finland
- Volunteers
- 2,600 people
- Sponsor
- Kuopio University Hospital
Cardiac Arrest, Out-Of-Hospital, Ketamine
The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study
Recent evidence suggests ketamine may attenuate harmful cellular cascades taking place after brain injury that result in permanent damage.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Ketamine, Neurologic Manifestations
- Trial name
- KetCat (NCT04360070)
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Fraser Health
Out-of-Hospital Cardiac Arrest
A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea
Therapeutic hypothermia after out-of-hospital cardiac arrest is considered as a standard care. However, optimal candidates, optimal dose, duration, timing of initiation and rate of rewarming is still unknown.
- Trial name
- NCT02827422
- Testing
- not provided
- Where
- South Korea
- Volunteers
- 1,800 people
- Sponsor
- Kyu Nam Park
Heart Arrest, Out-Of-Hospital
Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest
Phase II double blind (participants and investigator) placebo controlled randomized (1:1) clinical trial of inhaled nitric oxide (iNO) 20 ppm administered over 12h beginning as soon as possible but within 4 h of return of…
- Trial name
- iNOOHCA (NCT03079102)
- Testing
- Nitric Oxide, Nitrogen
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Cameron Dezfulian
Out-of-Hospital Cardiac Arrest
REBOA in Out-of-hospital Cardiac Arrest
Unexpected cardiac arrest is a frequent and devastating event with a high mortality and morbidity. Half of the patients who survive to ICU admission ultimately die because of hypoxic-ischemic encephalopathy.
- Trial name
- NCT04373122
- Testing
- REBOA
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Arrest
Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy
A prospective multicenter biomarker study with adult patients treated on intensive care units after out-of-hospital cardiac arrest.
- Trial name
- NCT06471972
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 1,500 people
- Sponsor
- Region Skane
Cardiac Arrest, Coma
Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades
New single use laryngoscope metal blades are available for intubation. This type of blade is safer than the reusable ones concerning the interhuman cross infection risk.
- Conditions
- Cardiac Arrest, Coma, Major Trauma, Respiratory Distress
- Trial name
- LAMETA (NCT00644722)
- Testing
- MacIntosh Green Lite (metal single use laryngoscope blades), MacIntosh Green Spec II (metal reusable laryngoscope blades)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Henri Mondor University Hospital
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study
Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiopulmonary Resuscitation
- Trial name
- TANGO2 (NCT03981107)
- Testing
- Chest Compression Only CPR (CO-CPR) performed by trained bystanders after instructions from dispatchers, Standard CPR (S-CPR) performed by trained bystanders after instructions from dispatchers
- Where
- 2 sites in Italy, Sweden
- Volunteers
- 3,260 people
- Sponsor
- Karolinska Institutet
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Out-Of-Hospital Cardiac Arrest
Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain…
- Trial name
- RIPOST-CA (NCT06473207)
- Testing
- Remote ischemic post conditioning sessions
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Coronary Artery Disease, Acute Myocardial Infarction
A Danish ICD-study in Patients with Coronary Artery Disease Resuscitated from Ventricular Fibrillation
DanICD is a randomized, controlled study to with the aim to assess whether there is a benefit of ICD-implantation in patients with coronary artery disease (including acute myocardial infarction), who survive cardiac arrest due to…
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Ventricular Fibrillation, Ventricular Tachycardia, Sustained
- Trial name
- DanICD (NCT04576130)
- Testing
- Implantable cardioverter defibrillator
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Out-Of-Hospital Cardiac Arrest
AED-delivery Using Drones in Out-of-hospital Cardiac Arrest
Time to defibrillation is the most important predictor of survival in cardiac arrest. Traditional emergency medical system response is often to slow.
- Trial name
- NCT04415398
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Out-Of-Hospital Cardiac Arrest
Wroclaw Out-Of-Hospital Cardiac Arrest Registry
The purpose of this study is to assess the efficacy of institutionalized care program of patients with out-of-hospital cardiac arrest.
- Trial name
- WOHCA (NCT05132387)
- Testing
- ECMO assisted CPR in out-of-hospital cardiac arrest
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Wroclaw Medical University
Cardiac Arrest
Coronariography in OUt of hosPital Cardiac arrEst
Prospective, multicenter, randomized clinical trial. Survivors from an out-of-hospital cardiac arrest (OHCA) without ST segment elevation in their EKG will be recruited.
- Trial name
- COUPE (NCT02641626)
- Testing
- Urgent Coronary Angiography, Deferred Coronary Angiography
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Hospital San Carlos, Madrid
Cardiac Arrest
Head-up Position and High Quality Cardiopulmonary Resuscitation in OHCA
Elevation of the head and thorax, also known as Head-up cardiopulmonary resuscitation (HUP CPR), has been studied extensively in pigs in ventricular fibrillation (VF).
- Trial name
- GRAVITY (NCT03996616)
- Testing
- Head UP Position, Impedance Threshold Device, New Automated CPR
- Where
- 2 sites in France
- Volunteers
- 126 people
- Sponsor
- University Hospital, Grenoble
Heart Arrest
BC ECPR Trial for Out-of-Hospital Cardiac Arrest
The addition of an Extracorporeal-Cardiopulmonary Resuscitation (ECPR) service to a region may improve the survival of young patients with sudden unexpected cardiac arrest.The primary aim of this study is to determine the benefit…
- Trial name
- NCT02832752
- Testing
- ECPR Protocol
- Where
- 3 sites in Canada
- Volunteers
- 308 people
- Sponsor
- University of British Columbia
Cardiac Arrest (CA)
The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region
Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency and one of the leading causes of death worldwide. Survival depends critically on how quickly help arrives and whether cardiopulmonary resuscitation (CPR) and…
- Trial name
- FIRSST-RER (NCT07589504)
- Where
- Italy
- Volunteers
- 5,200 people
- Sponsor
- Azienda Usl di Bologna
Cardiac Arrest
Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest
This study investigates the efficacy of landiolol versus placebo in patients with out-of-hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (electrical storm).
- Trial name
- Beta-Arrest (NCT05554978)
- Testing
- Landiolol, Sodium Chloride (NaCl) 0.9%
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Death, Sudden, Cardiac, Perfusion Index
Is the Perfusion Index an Accurate Predictor of Return of Spontaneus Circulation in Out-of-hospital Cardiac Arrest
The purpose of this pilot feasibility study is to evaluate the ability of the Perfusion Index to predict the return to spontaneous circulation of the out-of-hospital cardiac arrest patient during cardiopulmonary resuscitation.
- Conditions
- Death, Sudden, Cardiac, Perfusion Index, Return of Spontaneous Circulation
- Trial name
- NCT05383885
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre