Clinical trials: Heart Defects
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital
Marfan Syndrome
Tele-Clinic Visits in Pediatric Marfan Patients Using Parental Echo: The Future?
Marfan syndrome (MFS), a connective tissue disorder seen in 1 in 3,000 individuals, causes progressive aortic root dilation that can result in aortic dissection and sudden death.
- Trial name
- NCT03581682
- Testing
- Tele-Clinic Visits Using Parent-Acquired Echos
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Congenital Heart Defects
Trial of Cardiac Magnetic Resonance Imaging (MRI) Versus Cardiac Catheterization Prior to Glenn Operation
This study is a prospective, randomized study of patients with single ventricle heart disease who are to undergo superior cavo-pulmonary anastomosis, or "Glenn" operation.
- Trial name
- NCT00112424
- Testing
- Diagnostic cardiac MRI, Cardiac catheterization
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Defects
Autologous Fresh Whole Blood and Coagulation Following Cardiopulmonary Bypass in Infants
Dilution of blood caused by cardiopulmonary bypass (the heart-lung machine) during open heart surgery is associated with decreased concentrations in the blood of coagulation factors.
- Trial name
- NCT00006186
- Testing
- Autologous fresh whole blood
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Turner Syndrome, Ovarian Insufficiency
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population.
- Trial name
- CRYO-X0 (NCT01410045)
- Testing
- Ovariectomy
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Anomaly
Cardiac Resynchronization Under Electroanatomical Guidance After Failure of Primary Implantation
The purpose of the study is to assess the feasibility of cardiac resynchronization under electroanatomic guidance in the event of primary implantation failure due to catheterization failure or instability in the coronary sinus…
- Trial name
- CRT3D (NCT05429645)
- Testing
- setting up of the pace maker
- Where
- France
- Volunteers
- 12 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Congenital Heart Disease, Fallot Tetralogy
Prospective Evaluation of Programmed Ventricular Stimulation Before Pulmonary Valve Replacement in Patients With Tetralogy of Fallot
Severe pulmonary regurgitation is common in patients with Tetralogy of Fallot and results in progressive right ventricular dilatation and dysfunction.
- Conditions
- Congenital Heart Disease, Fallot Tetralogy, Ventricular Arrythmia, Pulmonary Valve Regurgitation
- Trial name
- NCT04205461
- Testing
- Programmed ventricular stimulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Paris Cardiovascular Research Center (Inserm U970)
Congenital Heart Disease
Myocardial Perfusion and Scarring in Congenital Heart Disease
Background: People with congenital heart disease may develop heart failure earlier that those who do not have the disease. One theory to explain this is that the heart s own blood supply may be different in people with congenital…
- Trial name
- NCT01639937
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease
Limbs Range of Motion Exercises Along With Chest Physical Therapy After Correction of Congenital Heart Diseases in ICU
1. To determine the effect of limb ROMs along with chest Physical therapy on cardiopulmonary parameters after correction of congenital heart diseases in ICU 2.
- Trial name
- NCT05425173
- Testing
- Conventional treatment, Limb Range of Motion Exercises + Chest Physical Therapy
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Long QT Syndrome
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
The purpose of this study is to determine whether late sodium channel blockade might be effective in shortening the QTc interval in various LQT3 mutations and be considered as a safe therapeutic option for LQT3 patients.
- Trial name
- NCT01648205
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Transcatheter Neonatal Cardiac Interventions
Neonatal Transcatheter Cardiac Interventions at Sohag University Hospital
This study is performed to assess the safety, efficacy and outcome of transcatheter cardiac interventions in neonates with critical congenital heart disease at Sohag University Hospital
- Trial name
- NCT06126484
- Testing
- transcatheter cardiac intervention
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Long QT Syndrome Type 3
Effect of Eleclazine on Shortening of the QT Interval, Safety, and Tolerability in Adults With Long QT Syndrome Type 3
The primary objective of this study is to evaluate the effect of oral eleclazine on mean daytime QTcF interval after 24 weeks of treatment with elecalzine in participants with long QT syndrome Type 3.
- Trial name
- NCT02300558
- Testing
- Eleclazine
- Where
- 12 sites in United States, Canada and 6 more
- Volunteers
- 41 people
- Sponsor
- Gilead Sciences
Patent Ductus Arteriosus
Efficacy and Safety of Oral Versus Intravenous Ibuprofen for PDA Treatment in ELBW Infants
To determine whether oral or intravenous ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosis in extremely-low-birth-weight preterm infants.
- Trial name
- NCT01261117
- Testing
- oral ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Congenital Heart Disease, Edema
Point of Care Ultrasound Measurements of Perioperative Edema in Infants With Congenital Heart Disease
Babies can be born with heart problems and sometimes need a heart surgery to fix the heart problem. Heart surgery can cause swelling from the build-up of extra fluid.
- Conditions
- Congenital Heart Disease, Edema, Fluid Overload
- Trial name
- NCT04151160
- Testing
- Point of care ultrasound measurements
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Congenital Heart Disease
Does Modified Ultrafiltration Affect Thromboelastography Results?
The study is to evaluate the effect of modified ultrafiltration on different components of Thromboelastography (TEG) in neonates undergoing cardiac surgery using cardiopulmonary bypass.
- Trial name
- NCT03214120
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Turner Syndrome, Bicuspid Aortic Valve
Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome
The study aim is: 1. To examine aortic tissue by light microscopy 2. To examine aortic tissue by electron microscopy 3. To study changes in the epigenome and transcriptome of the X chromosome specific to aortic tissue. 4.
- Conditions
- Turner Syndrome, Bicuspid Aortic Valve, Marfan Syndrome
- Trial name
- NCT01760668
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- University of Aarhus
Cyanotic Congenital Heart Disease, Anemia
Erythropoietin to Prevent Unnecessary Transfusions In Patients With Cyanotic CHD - A Prospective Control Trial
Cyanotic congenital cardiac patients require higher hemoglobin concentrations (red blood cell levels) for optimal oxygen delivery to the body.
- Conditions
- Cyanotic Congenital Heart Disease, Anemia, Cyanosis, Congenital Heart Disease
- Trial name
- NCT02564796
- Testing
- Epoetin Alfa and Iron, Iron
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Cardiovascular Disease Other, Physical Activity
Young Adult Congenital Heart Disease Physical Activity Lifestyle Study (YACHD-PALS)
This study will adapt a physical activity lifestyle intervention to emerging adult congenital heart disease (CHD) survivors with the primary goal of increasing physical activity levels. The study will be split into 2 phases.
- Trial name
- YACHD-PALS (NCT04135859)
- Testing
- Physical Activity Lifestyle Intervention, Physical Activity Monitoring
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Jamie Jackson
Transposition of the Great Arteries, Artery Switch Operation
Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults
Magnetic Resonance Imaging of the heart at rest and stress conditions relative to the cardiopulmonary exercise capacity in young adults after neonatal surgery for transposition of the great arteries.
- Trial name
- ASO (NCT02415491)
- Testing
- Correlation Heart Magnetic Resonance Imaging at rest and stress with Cardiopulmonary stress test
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Ambulatory Children With Single Ventricle
NIRS Monitoring in the Ambulatory Single Ventricle Patient
The normal heart has four chambers. There are two upper (or filling) chambers and are called the atrium. There are two lower (or pumping) chambers and are called the ventricles.
- Trial name
- NCT00166218
- Testing
- near-infrared spectroscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
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