Clinical trials: Heart Defects
Chylothorax
Chylothorax Following Heart Surgery
The purpose of this study is to determine at risk populations for certain congenital heart defects or certain operative procedures and to define the associated morbidity secondary to chylothorax - prolonged chest tube drainage…
- Trial name
- NCT00215098
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Heart Disease
"Critical State" Early Warning Score After CHD Surgery and Rapid Response Team
By establishing a warning scoring tool for the early \"critical state\" after congenital heart disease surgery, the multidisciplinary rapid response team is proactively activated, forming an integrated treatment model of…
- Trial name
- NCT06578312
- Where
- China
- Volunteers
- 4,115 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Defects, Congenital, Rehabilitation
Development and Improvement of Home Rehabilitation Scheme for Preschool Children With Congenital Heart Disease After Operation
This part of the study focuses on understanding the home rehabilitation situation for preschool children with congenital heart disease after operation.
- Conditions
- Heart Defects, Congenital, Rehabilitation, Preschool Child, Qualitative Research
- Trial name
- NCT07055334
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Congenital Heart Disease
MyHeartBaby: An Initial Evaluation of the MyHeartBaby Psychosocial Telemedicine Program
This study will conduct an initial clinical evaluation of this support program to examine its impact on reducing caregiver stress, increasing confidence in daily feeding, and improving weight-for-age growth percentiles in infants…
- Trial name
- NCT02895334
- Testing
- MyHeartBaby Program
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emory University
Congenital Heart Disease
Perioperative Outcome of Congenital Heart Disease Surgery in Childhood
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese…
- Trial name
- NCT04093011
- Testing
- Congenital Heart Disease Surgery
- Where
- China
- Volunteers
- 6,500 people
- Sponsor
- Nanjing Medical University
Down Syndrome, Trisomy 18
VAlidation of a Lower Cost aneUploidy scrEen
This study will document the detection rate and false positive rate as well as failure rate of a new prenatal screening approach ('Smart NIPT') as described at www.vanadisdx.com and implemented in an academic laboratory with…
- Conditions
- Down Syndrome, Trisomy 18, Trisomy 13
- Trial name
- VALUE (NCT03087357)
- Testing
- SmartNIPT
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 2,443 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Sepsis, Congenital Heart Disease
Study of Hemodynamics of Neonates by Echocardiography and USCOM
The purpose of this study is to evaluate the hemodynamic values of neonates that are healthy and those with various congenital heart diseases and sepsis by using echocardiography and USCOM.
- Trial name
- HNEU (NCT01045252)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Patent Ductus Arteriosus
IV Acetaminophen and Patent Ductus Arteriosus
This is a randomized controlled trial to evaluate the efficacy of IV acetaminophen versus IV ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants.
- Trial name
- NCT03008876
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Aneurysm Aortic Root, Aortic Valve, Bicuspid
Aortic Valve Dynamics During Exercise After Valve Sparing Root Replacement Surgery
Aortic valve sparing operations are applied in patients with a non-calcified tricuspid or bicuspid aortic valve associated with a root aneurysm, in order to preserve the valve, and avoid new aortic dilatation by stabilizing the…
- Trial name
- NCT04205474
- Testing
- graded bicycle test
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Premature Infant, Patent Ductus Arteriosus
Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.
The proposed research evaluates tissue oxygenation (StO2) as measured by resonance raman spectroscopy (RRS) in premature infants with and without patent ductus arteriosus (PDA).
- Conditions
- Premature Infant, Patent Ductus Arteriosus, Hemodynamic Instability
- Trial name
- NCT03277768
- Testing
- Resonance Raman Spectroscopy (RRS)
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Florida
Epilepsy (treatment Refractory)
Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial）
Patent foramen ovale (PFO) is the most common cause of right-to-left shunt (RLS) in the adult heart, with a prevalence of approximately 25% in the general population.
- Trial name
- PREDICT-PFO (NCT06863350)
- Testing
- patent foramen ovale closure
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sichuan University
Normal Values of Nasal Nitric Oxide in Healthy Adults
Determination of Normal Values of Nasal Nitric Oxide in Adults
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired airway mucociliary clearance leading to recurrent respiratory infections, bronchiectasis and eventually respiratory insufficiency.
- Trial name
- NCT02133547
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Congenital Heart Disease (CHD)
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
This is a two-arm, prospective, longitudinal, randomized controlled trial (RCT) that will compare usual care to usual care plus a prenatally initiated, virtually administered psychological intervention, called HeartGPS.
- Trial name
- NCT07582861
- Testing
- HeartGPS
- Where
- 17 sites in United States
- Volunteers
- 210 people
- Sponsor
- Carelon Research
Congenital Heart Disease
Digital Health Nudging in Adolescents With Congenital Heart Disease
In adolescents with congenital heart disease physical activity level is reduced which is why promotion to a more active lifestyle with an age-appropriate and modern intervention is needed.
- Trial name
- NCT04933786
- Testing
- Digital Health Nudging
- Where
- Germany
- Volunteers
- 97 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Congenital Heart Disease, Fontan
Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients
The study involves documenting the effects of inhaled nitric oxide upon ventricular-arterial coupling in patients with congenital heart disease and passive pulmonary blood flow.
- Trial name
- NCT01607983
- Testing
- inhaled nitric oxide
- Where
- United States
- Sponsor
- University of California, San Francisco
Congenital Heart Disease
Enhanced Physical Activity Support in Congenital Heart Disease Clinical Care
Our cluster randomized controlled trial of a novel clinical practice change will IMPACT the physical activity (PA) of children living with congenital heart defects (CHD) through our Innovative and pragmatic approach to…
- Trial name
- PAToolKit (NCT03435354)
- Testing
- Physical activity counselling
- Where
- 3 sites in Canada
- Volunteers
- 155 people
- Sponsor
- Children's Hospital of Eastern Ontario
Ventricular Septal Defect
Cardiopulmonary Function in Adults Born With a Ventricular Septal Defect
The overall objective for this study is to evaluate the cardiopulmonary function of VSD-patients compared with healthy age- and gender-matched controls.
- Trial name
- NCT03684161
- Testing
- Cardiopulmonary function
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
ASD2(Secundum Atrial Septal Defect)
Dapagliflozin and Right Heart Recovery After ASD Device Closure
The aim of this study is to evaluate the clinical and echocardiographic influence of dapagliflozin on right ventricular reverse remodeling in adult patients following successful transcatheter Atrial Septal Defect (ASD) device…
- Trial name
- NCT07823972
- Testing
- trans catheter device closure
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
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