Clinical trials: Heart Defects
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Patent Ductus Arteriosus, Surgery
Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus
The primary goal of the trial is to compare two different Patent Ductus Arteriosus (PDA) treatment approaches: 1) an "early treatment" approach or 2) a "conservative" approach.
- Conditions
- Patent Ductus Arteriosus, Surgery, Necrotizing Enterocolitis, Intestinal Perforation
- Trial name
- PDA:TOLERATE (NCT01958320)
- Testing
- pharmacologic treatment of the PDA, no pharmacologic treatment of the PDA, NSAID
- Where
- 18 sites in United States, Sweden and 2 more
- Volunteers
- 202 people
- Sponsor
- University of California, San Francisco
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Silent Stroke, Pulmonary Embolism
Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO)
Pulmonary embolism is associated with a small but definite risk of paradoxical embolism in patients with a patent foramen ovale (PFO).
- Conditions
- Silent Stroke, Pulmonary Embolism, Patent Foramen Ovale
- Trial name
- ICEP (NCT00831259)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Caen
Primary Ciliary Dyskinesia, Kartagener Syndrome
Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia
Impaired pulmonary function, decreased physical activity, functional capacity and depending on these factors are reported in patients with primary ciliary dyskinesia in recent studies.
- Conditions
- Primary Ciliary Dyskinesia, Kartagener Syndrome, Immotile Cilia Syndrome
- Trial name
- NCT03832491
- Testing
- Home based therapy, Game and home based therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Turner Syndrome, Primary Ovarian Insufficiency
Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome
This is a research study to find out if treatment with transdermal estradiol patches started between 8 to 11.5 years is safe in girls with Turner syndrome who have ovarian failure and to see whether it may improve performance on…
- Trial name
- NCT07784582
- Testing
- Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's National Research Institute
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Disorders and Postoperative Delirium in Children Undergoing Congenital Heart Surgery
The investigators are going to conduct a prospective observational cohort study in pediatric patients aged 28 days to 14 years old scheduled for elective cardiac surgery with cardiopulmonary bypass.
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06686550
- Testing
- This is a observational study and there is no intervention.
- Volunteers
- 435 people
- Sponsor
- Yan Fuxia
Down Syndrome, Edwards Syndrome
Non-Invasive Screening for Fetal Aneuploidy
The purpose of this study is to determine if a laboratory test developed by the Sequenom Center for Molecular Medicine (SCMM) that uses a new marker found in the mother's blood can better identify pregnancies that have a child…
- Trial name
- NCT00847990
- Testing
- Maternal blood screening test for fetal aneuploidy
- Where
- 25 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Sequenom, Inc.
Congenital Heart Defects
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
Congenital heart defects (CHD) are the most common major human birth malformation, affecting ~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in…
- Trial name
- CHD GENES (NCT01196182)
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 32,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Defects, Dysfunctional Right Ventricular Outflow Tract Conduits
Melody Transcatheter Pulmonary Valve Study: Post Approval Study of the Investigational Device Exemption Cohort
The primary objective is to confirm the long-term functionality of implantation of the Medtronic Melody TPV at 5 years is no worse than the historical control established through literature review.
- Trial name
- NCT00740870
- Testing
- Transcatheter Pulmonary Valve replacement
- Where
- 5 sites in United States
- Volunteers
- 171 people
- Sponsor
- Medtronic Cardiovascular
Congenital Heart Defect
A Feasibility Study of Physical Activity After Surgical or Catheterization Intervention
This feasibility study will assess whether a 6-month, home-based, parent-led physical activity program, completed after surgical or catheterization treatment, enables young children with congenital heart defects (CHD) to achieve…
- Trial name
- NCT04619745
- Testing
- Individualized Home and Play-Based Physical Activity Plans
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Children's Hospital of Eastern Ontario
Patient Decision Aids, Congenital Heart Disease
Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making
This study is a randomized clinical trial where participants (parents of a fetus or neonate diagnosed with a life-threatening congenital heart disease (CHD)) will randomly be assigned to either receiving a web-based decision aid…
- Conditions
- Patient Decision Aids, Congenital Heart Disease, Congenital Heart Defect
- Trial name
- NCT04437069
- Testing
- Decision Aid, Values Clarification Exercise
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Utah
Congenital Heart Surgery, Congenital Heart Defects
Death Following Congenital Heart Surgery
The purpose of this study is to elucidate the patterns of death following congenital heart surgery.
- Trial name
- NCT00215072
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Respiratory Distress Syndrome, Newborn, Patent Ductus Arteriosus
Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome
In preterm infants with neonatal respiratory distress syndrome (RDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal incidences of bronchopulmonary…
- Conditions
- Respiratory Distress Syndrome, Newborn, Patent Ductus Arteriosus, Bronchopulmonary Dysplasia, Preterm
- Trial name
- NCT04984057
- Testing
- PS is stopped when the pressure is equal between bPDA and aPDA., PS is given according to the 2019 European RDS management guideline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Cardiac Congenital Defects
Volume Versus Pressure Ventilation on Lung Atelectasis
This prospective randomized comparative study, to assess post-operative lung atelectasis by comparing calculated lung score using ultrasound between pediatric patients intubated with LMA (laryngeal mask airway) under volume…
- Trial name
- NCT06076395
- Testing
- LMA (Laryngeal Mask Airway)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Congenital Heart Disease
Proposal for Parental Guidance and Early Stimulation in Children With Congenital Heart Disease: Randomized Trial
Problem: With the increased survival rate of children with congenital heart disease, other health problems, in addition to the clinic, have emerged, such as the risks of developmental delay to which these children are exposed.
- Trial name
- NCT04152330
- Testing
- Early stimulation protocol on neuropsychomotor development of children with congenital heart disease
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Heart Defects, Congenital
Rejuvenated, Washed Packed Red Blood Cells in Pediatric Cardiac Surgery
Blood transfusion is nearly always needed during open heart surgery in children less than 15 kg (35 pounds). The purpose of the red blood cells in the blood is to deliver oxygen to the organs and tissues of the body.
- Trial name
- NCT02485366
- Testing
- Rejuvesol, Cardiac surgery
- Where
- United States
- Sponsor
- Duke University
Aortic Arch Hypoplasia or Atresia
Modified Perfusion for Neonatal Aortic Arch Reconstruction
Even though the lower part of the body does receive some blood supply during Cardiopulmonary Bypass(CPB) surgery, it may not be enough.
- Trial name
- NCT00490256
- Testing
- Modified Selective Cerebral Perfusion
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Patent Foramen Ovale, Ischemic Stroke
Patent Foramen Ovale Closure in Older Patients
Describe the baseline and procedural characteristics of older patients undergoing PFO closure due to cryptogenic embolism. Assess the long-term follow-up of this cohort, focusing on neurological events and their origin, major…
- Conditions
- Patent Foramen Ovale, Ischemic Stroke, Older People
- Trial name
- PFO-Elderly (NCT04780022)
- Testing
- Clinical events at last follow-up
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
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