Clinical trials: Heart Disease, Coronary
Coronary Artery Disease, Heart Failure
Harmonica Exercises for Patients Undergoing Cardiac Rehabilitation.
The study aims to assess the effects of exercises using the harmonica on the exercise capacity, the level of depressive symptoms and disease related quality of life in patients suffering from heart disease attending cardiac…
- Trial name
- HARMONYCR (NCT06647212)
- Testing
- introducing breathing exercises with the harmonica
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Katarzyna Piotrowicz
Mitral Valve Regurgitation
Mitral Valve Replacement With MValve Dock and Lotus
This study evaluates the MValve mitral prosthesis in conjunction with a Lotus transcatheter heart valve (THV) for mitral valve replacement in subjects at high risk for conventional mitral valve replacement or repair surgery.
- Trial name
- DOCK 1 (NCT02719912)
- Testing
- mitral valve replacement
- Where
- 4 sites in Brazil, France and 2 more
- Volunteers
- 30 people
- Sponsor
- MValve Technologies Ltd
De Novo Stenosis, Coronary Artery Disease
Paclitaxel-Coated Balloon Versus Zotarolimus-Eluting Stent for Treatment of De Novo Coronary Artery Lesions
Coronary restenosis has been one of the main reasons affecting the prognosis of patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI).
- Conditions
- De Novo Stenosis, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- CAGE-FREEIII (NCT05209412)
- Testing
- Lepu Paclitaxel coated balloon, Resolute Integrity Zotarolimus eluting stents, Aspirin
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Xijing Hospital
Cardiovascular Diseases, Heart Diseases
Effects of Citalopram on Hostility and CHD Risk
To evaluate the therapeutic effects of the serotonergic agent, citalopram, on hostility and other behavioral risk factors, and biological markers of disease risk (serum lipids, insulin and glucose; autonomic balance and…
- Trial name
- NCT00217828
- Testing
- citalopram
- Sponsor
- University of Pittsburgh
Out-Of-Hospital Cardiac Arrest
Prognostic Value of P30 After Cardiac Arrest
This study aims to examine whether P30 wave of somatosensory evoked potentials (SEP) is related with outcome after cardiac arrest. The study design is a prospective, multicenter-observational study.
- Trial name
- NCT03175965
- Testing
- Somatosensory evoked potential
- Where
- 4 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- Uijeongbu St. Mary Hospital
Refractory Angina Pectoris, Ischemic Heart Disease
Cardiac Shock Wave Treatment in Patients With Reduced Coronary Flow Reserve
The purpose of the study is to assess the feasibility of Cardiac Shock Wave Treatment in patients with anginal chest pain and evidence of abnormal myocardial perfusion under stress in the absence of significant stenoses of the…
- Conditions
- Refractory Angina Pectoris, Ischemic Heart Disease, Coronary Artery Disease
- Trial name
- NCT03438500
- Testing
- Cardiac Extracorporeal Shockwave Therapy (Modulith SLC)
- Where
- Germany
- Sponsor
- Storz Medical AG
Coronary Heart Disease (CHD), PCI
Effects of Dioscorea Yam Gruel on Blood Lipid Profiles in PCI Patients With Coronary Heart Disease
This randomized controlled trial investigated the effects of Dioscorea yam gruel on blood lipid levels in patients with coronary heart disease after percutaneous coronary intervention (PCI).
- Trial name
- NCT07589036
- Testing
- Standard Post-PCI Care, Dioscorea Yam Gruel
- Where
- China
- Volunteers
- 72 people
- Sponsor
- 900th Hospital of PLA Joint Logistic Support Force
Preeclampsia, Hypertensive Disorder of Pregnancy
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications
- Trial name
- HHD (NCT05655936)
- Testing
- Heart Health Doula Intervention Program, Usual Care
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- University of Pittsburgh
ST Segment Elevation Myocardial Infarction, Left Ventricular Thrombus
Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant
Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events.
- Trial name
- EARLYmyo-LVT (NCT03764241)
- Testing
- Rivaroxaban, Vitamin K Antagonist
- Where
- China
- Volunteers
- 280 people
- Sponsor
- RenJi Hospital
Persistent Atrial Fibrillation
Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation
Procedures for ablation of persistent or long lasting atrial fibrillation are frequently long and require extensive ablation. Some electrophysiologists administer the drug ibutilide during these procedures to help organize the…
- Trial name
- MAGIC-AF (NCT01014741)
- Testing
- Ibutilide
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 200 people
- Sponsor
- Vivek Reddy
Coronary Artery Disease, Elderly (Aged >70)
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
This study is a prospective multi-center observational cohort involving elderly patients (≥70 years old) with multi-vessel coronary disease identified by coronary computed tomography angiography (cCTA) and scheduled for invasive…
- Trial name
- NCT07311954
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 800 people
- Sponsor
- China National Center for Cardiovascular Diseases
Left Ventricular Insufficiency
Safety Study of Chimeric Natriuretic Peptide(CD-NP) in Stable LVAD Patients
The most promising chimeric natriuretic peptide designed and studied by our group has been CD-NP which has anti-fibrotic and cardioprotective properties in vivo, vitro and in normal volunteers and human heart failure patients.
- Trial name
- NCT01750905
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Patent Ductus Arteriosus, Neonate
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus
Patent ductus arteriosus or PDA is a blood vessel that connects the right and left side of the heart that usually closes after birth but remains open in some premature infants born before 30 weeks' gestation.
- Trial name
- NCT03103022
- Testing
- Acetaminophen, ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Pain, Arrythmia
Assessment of the Effect of Clonidine for Cataract Surgery
Clonidine, an agonist for alfa2 pre-synaptic, has been shown to be an effective adjuvant therapy for acute postoperative pain and has been shown an effect in sedative, intra-ocular and blood pressure and arrhythmias.The objective…
- Trial name
- NCT01677351
- Testing
- Clonidine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Heart Diseases
Level of Accelerometer-assessed Preoperative Physical Activity and Short Term Outcome After Elective Cardiac Surgery
Short term morbidity after elective cardiac surgery remains significant. Standard predictive models, considering simple patient demographics and clinical parameters, show limited efficiency in individual operative risk…
- Trial name
- ACTI-CARD (NCT04140331)
- Testing
- Accelerometer
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Coronary Artery Occlusive Disease
A Trial Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness in Patients With Coronary Artery Disease After Biolimus Eluting Stent (Nobori®) Implantation: CPR IMT
Current consensus papers recommend statin medication to reduce Low density lipoprotein (LDL) cholesterol level less than 100mg/dL (optional 70mg/dL) in patients with coronary artery disease.
- Trial name
- NCT01872845
- Testing
- Pravastatin 40mg, Rosuvastatin
- Where
- South Korea
- Volunteers
- 671 people
- Sponsor
- Yonsei University
Idiopathic Pulmonary Fibrosis
Heart Rate Variability and Nocturnal Blood Oxygen Saturation in Patients With Idiopathic Pulmonary Fibrosis
The goal of this observational study is to compare the overnight heart rate variability (HRV) and nocturnal oxygen saturation (SpO2) in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT06027372
- Testing
- "LARGAN" ECG Holter
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Coronary Artery Disease
Post Marketing Clinical Trial to Demonstrate the Performance of the MedHub AutocathFFR Device.
Patients with suspected coronary artery disease who are scheduled to undergo a coronary angiography procedure will be enrolled in the study.
- Trial name
- NCT04724057
- Testing
- AutocathFFR
- Volunteers
- 488 people
- Sponsor
- Medhub Ltd.
Fetal Distress With Antenatal Problem, Fetal Growth Retardation
Validation of Sensors for Long-term Non-Invasive Fetal Monitoring
A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy.
- Trial name
- NCT06952777
- Testing
- Non-adhesive capacitively-coupled sensors
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Frailty, Coronary Artery Disease
Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients
Frailty is a major predictor of adverse outcomes following coronary artery bypass grafting (CABG), being associated with increased postoperative complications, prolonged hospitalization, delayed functional recovery, and reduced…
- Conditions
- Frailty, Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
- Trial name
- MINIFRAGILE (NCT07742475)
- Testing
- Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG), Conventional Coronary Artery Bypass Grafting (Median Sternotomy)
- Volunteers
- 194 people
- Sponsor
- University of Sao Paulo General Hospital
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