Clinical trials: Heart Disorder
Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1
Troriluzole in Adult Participants With Spinocerebellar Ataxia
The purpose of this study is to compare the efficacy of Troriluzole (200 mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).
- Conditions
- Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
- Trial name
- NCT03701399
- Testing
- troriluzole
- Where
- 23 sites in United States, China
- Volunteers
- 299 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Coronary Restenosis
Drug-eluting Stents vs. Drug-coated Balloon for Preventing Recurrent In-stent Restenosis
The purpose of this study is to establish the safety and effectiveness of paclitaxel eluting balloon (SeQuent Please) compared to coronary stenting with the Everolimus-eluting balloon expandable stent (Xience Prime or Xience…
- Trial name
- RESTORE (NCT01967199)
- Testing
- Everolimus-eluting balloon expandable stent, paclitaxel eluting balloon
- Where
- 11 sites in South Korea
- Volunteers
- 175 people
- Sponsor
- Seung-Jung Park
Bradyarrhythmias, AV Block Complete
Belgo-Luxembourg Leadless PM Registry
This is a single-arm, multicenter clinical study evaluating the long-term effectiveness and safety profile of the CE-marked and commercially available Aveir leadless pacemaker systems manufactured by Abbott.
- Conditions
- Bradyarrhythmias, AV Block Complete, AV Block-2Nd Degree-Type 1, Pacemaker
- Trial name
- BELLA (NCT07879716)
- Testing
- CT scan heart, 24 hour ambulatory ECG monitoring
- Where
- 9 sites in Belgium, Luxembourg
- Volunteers
- 190 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Failure, Acute Decompensated Heart Failure
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of…
- Trial name
- BTR EFS (NCT05291884)
- Testing
- Impella BTR
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abiomed Inc.
Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction
ST-elevation myocardial infarction (STEMI) is mostly caused by the rupture or the erosion of a vulnerable atherosclerotic plaque, initiating with intraluminal thrombosis and resulting in total occlusion of the coronary artery.
- Trial name
- NCT03731884
- Testing
- Time from the onset of symptoms to PCI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- G. d'Annunzio University
Coronary Artery Disease
Resting Full-cycle Flow Ratio (RFR) Versus Angiography to Guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG)
Different trials have shown that fractional flow reserve (FFR) could successfully guide revascularization in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- RFR-CABG (NCT04375306)
- Testing
- RFR guided CABG, Angio guided CABG
- Where
- 4 sites in Belgium, Poland and 1 more
- Volunteers
- 500 people
- Sponsor
- Diagram B.V.
Cardiovascular Diseases, Heart Diseases
Behavioral Factors in Coronary Heart Disease
To elucidate the role of biobehavioral factors in the etiology, pathogenesis and course of coronary heart disease (CHD) and to use this knowledge to devise more effective prevention, treatment and rehabilitation approaches.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Metabolic Syndrome X
- Trial name
- NCT00005314
- Volunteers
- 694 people, healthy volunteers welcome
- Sponsor
- Duke University
Aortic Stenosis, Severe Aortic Stenosis
Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study)
The purpose of this study is to see if having the Transcatheter Aortic Valve Replacement (TAVR) procedure done in a hospital with onsite cardiac surgery available or not, makes a difference on participant outcomes.
- Trial name
- ATLAS (NCT06818006)
- Testing
- Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight
- Where
- 2 sites in Canada
- Volunteers
- 600 people
- Sponsor
- University of Alberta
Cardiovascular Disease
Technology-enabled Cardiac Rehabilitation Through PATHway. Feasibility, Clinical Effectiveness and Cost-effectiveness
The PATHway system is designed to help patients remain physically active and maintain a good cardiovascular health. It proposes a novel approach that aims to empower patients to self-manage their CVD, set within a collaborative…
- Trial name
- PATHway (NCT02717806)
- Testing
- PATHway
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Cancer, Myocarditis
Randomized Controlled Study Evaluating the Efficacy of Hypnosis in Nuclear Medicine
In Nuclear Medicine, the examinations are long (20-60 minutes) and the patients must remain immobile, sometimes fasting. The anxiety of the latter can lead to poor quality examinations and sometimes, although already injected…
- Conditions
- Cancer, Myocarditis, Alzheimer Disease, Parkinson
- Trial name
- HYDEM (NCT06116084)
- Testing
- Ericksonian Hypnosis, Hypnosis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
A Trial to Learn How Safe Vericiguat (BAY1021189) is and the Way the Body Absorbs, Distributes and Gets Rid of Vericiguat in Participants With Kidney Disease and in Age-, Weight- and Gender-matched Healthy Participants
Vericiguat (BAY1021189) is under development to treat heart failure, a condition in in which the heart has trouble pumping blood through the body.
- Trial name
- NCT04722484
- Testing
- Vericiguat (BAY1021189)
- Where
- Germany
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bayer
Cardiac Output, Low, Cardiac Output, High
Comparing Cardiac Output Measurements Using a Wearable, Wireless, Non-invasive PPG-Based Device to a Swan Ganz Catheter
Invasive pulmonary capillary wedge pressure measurements using a Swan-Ganz catheter (SGC) is considered the gold standard for cardiac output (CO) monitoring.
- Conditions
- Cardiac Output, Low, Cardiac Output, High, Congestive Heart Failure
- Trial name
- NCT04955184
- Testing
- non-invasive monitoring
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Biobeat Technologies Ltd.
Heart Failure, Systolic
CardiAMP™ Cell Therapy for Heart Failure Trial
This is a prospective, multi-center, randomized, controlled, patient- and evaluator-blinded study comparing treatment with the CardiAMP cell therapy to a sham control treatment.
- Trial name
- NCT02438306
- Testing
- Autologous cell therapy
- Where
- 24 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- BioCardia, Inc.
Myocardial Infarction, Coronary Artery Disease
Safety and Efficacy Study of CYPHER® Sirolimus Stent and ENDEAVOR® Zotarolimus Stent in Patients With Acute ST Elevation Myocardial Infarction (STEMI) and Analysis of Current Status of Emergency PCI Green Channel for STEMI Patients in China
This study is to compare the clinical effect of CYPHER® stent and ENDEAVOR® stent in patients with acute ST elevation myocardial infarction.
- Trial name
- CREST-MI (NCT00781716)
- Testing
- Drug eluting coronary stent system
- Where
- China
- Volunteers
- 1,020 people
- Sponsor
- Beijing Chao Yang Hospital
Hypovolemia, Coronary Artery Disease
Predicting Fluid Responsiveness in on Pump Coronary Artery Bypass Graft Using Extra Systoles
The purpose of this study is to determine if extra systoles can be used to predict fluid responsiveness perioperatively in patients undergoing on pump coronary artery bypass graft (CABG) surgery.
- Conditions
- Hypovolemia, Coronary Artery Disease, Fluid Overload
- Trial name
- NCT02903316
- Testing
- Fluids
- Where
- Denmark
- Volunteers
- 95 people
- Sponsor
- University of Aarhus
Atrial Fibrillation
ECG-I Targeted Ablation for Persistent AF Not Responding to Pulmonary Vein Isolation Results of a Two Staged Strategy.
Atrial Fibrillation (AF) is a irregular heart rhythm associated with significant morbidity and mortality. Catheter ablation is a treatment where catheters are passed through the veins in the leg into the left atrium of the heart…
- Trial name
- TARGET-AF2 (NCT04633265)
- Testing
- ECG-I Mapping of Atrial Fibrillation
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Barts & The London NHS Trust
Coronary Artery Disease
Plant Sterols Effect on Previous Statin Therapy
The purpose of this study is to determine the effect of plant sterols associated with ezetimibe in LDL-cholesterol levels in coronary patients previously on statin therapy
- Trial name
- NCT02089867
- Testing
- Ezetimibe + plant sterols, Ezetimibe, Plant sterols
- Where
- Brazil
- Volunteers
- 47 people
- Sponsor
- Jose Rocha Faria Neto
Hypoxia, Normobaric Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Normobaric Hypoxia, Altitude Hypoxia, Right Heart Function
- Trial name
- RIVER-H (NCT07431567)
- Testing
- Normobaric Hypoxia
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mona Lichtblau
Congestive Heart Failure, Asthma
Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases
In this project, Institute of Bioengineering \& Bioimaging (IBB), A*STAR would like to collaborate with Massachusetts General Hospital to aggregate patient data and to further develop its software algorithm using machine learning…
- Conditions
- Congestive Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, Cystic Fibrosis
- Trial name
- NCT04825067
- Testing
- Respiratory Sensor measurements
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute of Bioengineering and Bioimaging (IBB)
Heart Failure
Finerenone and Cardiac Remodeling
The goal of this clinical trial is to learn if the drug finerenone (Karendia) can improve heart function in participants who are at risk for heart and kidney disease.
- Trial name
- FINE-MECH (NCT07270367)
- Testing
- Finerenone
- Where
- 3 sites in Canada
- Volunteers
- 156 people
- Sponsor
- Subodh Verma
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