Clinical trials: Heart Disorder
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
The TaRGET study is a multi-centre, prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the potential therapeutic efficacy of tideglusib, a glycogen synthase kinase-3 β inhibitor, in genotype…
- Trial name
- TaRGET (NCT06174220)
- Testing
- Tideglusib
- Where
- 17 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Complication Due to Immunization
Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants
Background: Inflammation may depress respiration in neonates. The aim of this study was to establish a link between post-immunization inflammation and cardio-respiratory events (CRE).
- Trial name
- NCT02726178
- Testing
- Advil® Pediatric drops for infants
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Atrial Fibrillation, Atrial Flutter
A Trial With Dronedarone to Prevent Hospitalization or Death in Patients With Atrial Fibrillation
To assess the efficacy of dronedarone in preventing cardiovascular hospitalization or death from any cause in a population of high-risk patients with atrial fibrillation/atrial flutter (AF/AFL).
- Trial name
- ATHENA (NCT00174785)
- Testing
- dronedarone (SR33589)
- Where
- 37 sites in United States, Argentina and 35 more
- Volunteers
- 4,628 people
- Sponsor
- Sanofi
Mitral Stenosis
Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
- Trial name
- NCT06067815
- Volunteers
- 30 people
- Sponsor
- Assiut University
Strabismus, Bradycardia
Strabismus Recovery With Proparacaine and Oculocardiac Reflex
Observational study to determine if topical anesthetic and intraoperative oculocardiac reflex influence post strabismus surgery recovery.
- Conditions
- Strabismus, Bradycardia, Nausea, Pain
- Trial name
- OCRprop (NCT03672435)
- Testing
- Topical Solution
- Volunteers
- 140 people
- Sponsor
- Alaska Blind Child Discovery
Aortic Valve Stenosis, Bicuspid Aortic Valve
Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI
Early development of calcified aortic valve disease (CAVD) is a commonly occurring complication in patients with a bicuspid aortic valve (BAV, an aortic valve consisting of two leaflets instead of three).
- Trial name
- BASIK2 (NCT02917525)
- Testing
- Vitamin K2
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation, Coronary Artery Disease
Comparison Between Direct Oral Anticoagulation (DOAC) Interruption and DOAC Continuation in Patients Undergoing Elective Invasive Coronary Angiography or Percutaneous Coronary Intervention
A prospective, multicenter, 1:1 randomized, investigator initiated study. Goal of this study is to examine the safety of uninterrupted periprocedural DOAC use.
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Anticoagulants
- Trial name
- SLIM-2 (NCT04977076)
- Testing
- Uninterrupted DOAC use, Interrupted DOAC use
- Where
- Netherlands
- Volunteers
- 1,270 people
- Sponsor
- Zuyderland Medisch Centrum
Heart Failure
SGLT2 for Heart Failure in CHD Patients
Heart failure (HF) in adult patients with congenital heart disease is a major cause of morbidity and mortality. Approximately 30% of patients with significant congenital heart disease will develop signs of heart failure.
- Trial name
- GACH (NCT05897489)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parent Mental Health
Preparing Heart and Mind™: A Patient Engagement Pathway for Parents and Their Caregiving Partners After a Major Fetal Anomaly Diagnosis
The purpose of this study is to test and evaluate the Preparing Heart and Mind™ (PHM™) patient engagement pathway as a nurse-guided intervention to lower psychological distress and enhance caregiving competencies among…
- Trial name
- NCT05282368
- Testing
- PHM™ Pathway
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Minnesota
Drug-eluting Stent, Coronary Artery Disease
Efficacy of OSFIT Drug-Eluting Stent in Coronary Ostial Artery Stenosis
The purpose of this observational study is to evaluate the long-term effectiveness and safety of the OSFIT drug-eluting stent designed to facilitate procedures in coronary artery lesions.
- Trial name
- NCT06066450
- Testing
- Genoss® DES system, Genoss® Osfit system
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Coronary Artery Disease
Very Early veRsus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes
The aim of this study is to evaluate if acute invasive coronary evaluation and treatment conducted within 12 hours of diagnosis improves clinical outcome compared to a deferred, subacute strategy in patients with unstable angina…
- Trial name
- VERDICT-EDI (NCT02061891)
- Testing
- Invasive coronary evaluation (Deferred), Invasive coronary evaluation (Acute)
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post-Operative Cancer Patients Experiencing Atrial, Fibrillation
Cardiac Monitoring of Post-Operative Cancer Patients Experiencing Atrial Fibrillation
The purpose of this study is to assess whether it is possible and acceptable to monitor patients at a distance who experience a condition called atrial fibrillation after their cancer surgery.
- Trial name
- NCT01253590
- Testing
- questionnaire about the use of ECG device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pulmonary Embolism
Risk Stratification and Prognostic Value of Right Ventricular Dysfunction Screening Using Transthoracic Echocardiography in Acute Pulmonary Embolism
This observational study evaluates right ventricular dysfunction in patients with acute pulmonary embolism using transthoracic echocardiography and assesses its prognostic significance and risk stratification value.
- Trial name
- RVD-PE (NCT07647497)
- Testing
- Transthoracic Echocardiography
- Where
- 2 sites in Egypt
- Volunteers
- 112 people
- Sponsor
- Sohag University
Acute Coronary Syndrome
A Pharmacist-Led Hospital-Based Intervention to Support Medication Adherence Following Acute Coronary Syndrome
Background Medication adherence following acute coronary syndrome (ACS) is often sub-optimal and is associated with poor clinical outcomes.
- Trial name
- NCT03218813
- Testing
- Intervention cohort ('after' group)
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London
Arrythmia
Patient Specific Optimized Therapy Post-Market Clinical Follow-up Study
Study to evaluate the safety and procedural performance of the KODEX - EPD System when used in the treatment of cardiac arrhythmias.
- Trial name
- PSOT-PMCF (NCT03481413)
- Testing
- Ablation
- Where
- 22 sites in United States, Belgium and 6 more
- Volunteers
- 566 people
- Sponsor
- EPD Solutions, A Philips Company
Muscle Wasting
Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Even with major advances in clinical therapy and percutaneous interventions, coronary artery bypass grafting (CABG) is the most common cardiac surgery performed worldwide and is an effective treatment in reducing symptoms and…
- Trial name
- NCT03560713
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal de Santa Maria
Heart Failure, Depression
Depression and Self-care in Heart Failure
The purpose of the study is to test whether Cognitive Behavior Therapy (CBT) plus heart failure self-care education is superior to "usual care" for depression.
- Trial name
- DASH (NCT01028625)
- Testing
- Cognitive Behavior Therapy, Heart Failure Self-care Education
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Washington University School of Medicine
Acute Kidney Injury, Neurological Injury
Mini Versus Conventional Cardiopulmonary Bypass In CABG in Asian Patients
Our intention is to perform a randomized controlled trial to compare the efficacy and safety of mini cardiopulmonary bypass system to a modified conventional bypass circuit in 80 Asian patients undergoing elective CABG.
- Trial name
- MiniCPB (NCT03657225)
- Testing
- Utilization of the mini CPB circuit, Utilization of the conventional circuit
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
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