Clinical trials: Heart Disorder
Heart Failure, Bradycardia
Bolt CSP-M Holter Study
The purpose of this study is to investigate the cardiac electrical characteristics in different pacing outputs and body positions in LBB area pacing (LBBAP), from which the findings may help to develop and support data validation…
- Trial name
- NCT06540521
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- 95 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Sinus Bradycardia
Cardiac Denervation Ablation Strategy for Severe Sinus Bradycardia
This is a prospective clinical observation and registration study. The investigator aimed to evaluate the efficacy and safety of cardiac denervation ablation as a treatment strategy for severe sinus bradycardia.
- Trial name
- NCT06276816
- Where
- China
- Volunteers
- 88 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndromes
Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain
The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine
- Trial name
- NCT00718406
- Testing
- Metoprolol, metoprolol plus morphine
- Where
- Sweden
- Sponsor
- Sahlgrenska University Hospital
Obesity, Overweight
Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)
The purpose of this study is to determine the effects of NB relative to placebo on major adverse cardiovascular events (MACE) such as cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in overweight and…
- Trial name
- NCT01601704
- Testing
- NB32, PBO, Weight Management Program
- Where
- 224 sites in United States
- Volunteers
- 8,910 people
- Sponsor
- Orexigen Therapeutics, Inc
Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD)
Revascularization of Calcified Coronary Arteries
The primary aim of this study is to evaluate changes in absolute coronary flow and pressure before and after percutaneous coronary intervention in calcified lesions.
- Conditions
- Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD), Percutaneous Coronary Intervention (PCI)
- Trial name
- PICA (NCT07724184)
- Testing
- Measurement of coronary flow and pressure
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction
The goal of this clinical trial is to test an experimental gene therapy in participants with heart failure with preserved ejection fraction, also known as diastolic heart failure.
- Trial name
- MUSIC-HFpEF (NCT06061549)
- Testing
- AAV1/SERCA2a
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sardocor Corp.
Congestive Heart Failure
SyncAV Post-Market Trial
The SyncAV Post-Market Trial is a prospective, randomized, multi-center trial performed to determine if cardiac resynchronization therapy (CRT) devices programmed with SyncAV ON improve long-term CRT response compared to devices…
- Trial name
- SyncAV (NCT04100148)
- Testing
- SyncAV programmed ON, Fixed AV delay
- Where
- 104 sites in United States, Austria and 23 more
- Volunteers
- 1,686 people
- Sponsor
- Abbott Medical Devices
Cardiac Disease
Study for the Assessment of the Quality of Echocardiographic Clips.
This study main objective is to evaluate the safety and efficacy of the UltraSight AI Guidance software. The investigational product is a software that guides the user to capture a high quality ultrasound image.
- Trial name
- NCT05090748
- Testing
- Echocardiographic.
- Where
- 3 sites in United States, Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- UltraSight
Mitral Regurgitation (MR)
Safety and Feasibility Study of the MitraFix® Transcatheter Mitral Valve System
The goal of this early feasibility clinical trial is to test a new device called the MitraFix® Transcatheter Mitral Valve System.
- Trial name
- MITRA-EFS (NCT07501234)
- Testing
- MitraFix® Transcatheter Mitral Valve System
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Mitrassist Lifesciences Limited Co., Ltd.
Heart Failure
Stem Cell Therapy in IschEmic Non-treatable Cardiac Disease
The aim of the SCIENCE study is, in an international multicentre double-blind placebo-controlled study, to investigate efficacy of direct intra-myocardial injection of 100 mio.
- Trial name
- SCIENCE (NCT02673164)
- Testing
- CSCC_ASC
- Where
- Denmark
- Volunteers
- 133 people
- Sponsor
- JKastrup
Small Cell Lung Carcinoma
A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer
Study to evaluate the effect of rovalpituzumab tesirine on cardiac ventricular repolarization in subjects with small cell lung cancer (SCLC).
- Trial name
- NCT02874664
- Testing
- Rovalpituzumab Tesirine
- Where
- 15 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Stemcentrx
Coronary Disease, Hypolipoproteinemia
Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)
The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on lipid profile…
- Trial name
- NCT00298909
- Testing
- physical exercise, niaspan (extended-release niacin), niacin
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Leipzig
CABG, Aortic Dissection
CLEAR Trial: CA330 Cytokine Adsorption Column for Anticoagulant/Antiplatelet Patients in Non-Elective CPB Surgery.
The goal of this clinical trial is to evaluate whether the CA330 cytokine adsorption column can reduce perioperative severe bleeding adverse events in patients receiving anticoagulant and/or antiplatelet therapy who undergo…
- Conditions
- CABG, Aortic Dissection, Valvular Heart Diseases
- Trial name
- CLEAR (NCT07284199)
- Testing
- CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Periodontal Diseases, Coronary Artery Disease
Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects
Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease.
- Trial name
- NCT04127487
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Heart Failure
Transplantation of Autologous Cardiac Stem Cells in Ischemic Heart Failure
This study is a prospective, randomized, double blind , controlled trial to assess the efficacy of intracoronary transplantation of autologous cardiac stem cells in 50 patients with ischemic heart failure.
- Trial name
- NCT01758406
- Testing
- Intracoronary injection
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Royan Institute
Aortic Valve Stenosis
Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli
In Europe TAVI is now recommended for treatment of aortic valve stenosis from the age of 70 years. When performing TAVI in young patients, lifetime management becomes important in terms of anticipated TAVI-in-TAVI procedures when…
- Trial name
- BALANCE (NCT07794306)
- Testing
- Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system
- Where
- Germany
- Volunteers
- 510 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure
REDUCE LAP-HF TRIAL II
Multicenter, Prospective, Randomized Controlled, Blinded Trial, with a Non-implant Control group; 1:1 randomization.
- Trial name
- NCT03088033
- Testing
- IASD System II implant, intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
- Where
- 91 sites in United States, Australia and 13 more
- Volunteers
- 608 people
- Sponsor
- Corvia Medical
Mitral Valve Regurgitation
Hemodynamic Stress Test in Severe Mitral Regurgitation (HEMI)
The preferred treatment of organic mitral regurgitation (MR) is mitral valve repair. Optimally this should be timed so late that it commensurate with the risk of surgery and before irreversibly damage of the heart and pulmonary…
- Trial name
- HEMI (NCT02961647)
- Testing
- Mitral valve repair
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Odense University Hospital
Aortic Stenosis
Identification of Parameters in rapId-proGression Subgroup Patients With Moderate Aortic Stenosis
The investigators aim to identify all clinical, biological, echo and imagistic parameters that predispose to increased progression rates in a prospective observational trial which will include ONLY patients with moderate AS, with…
- Trial name
- ENIGMAS (NCT01575249)
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
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