Clinical trials: Heart Disorder
Delirium, Surgery-Complications
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients…
- Trial name
- MD FluNCS (NCT06969287)
- Testing
- Fluvoxamine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Washington University School of Medicine
Septic Shock, Left Ventricular Systolic Dysfunction
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
Septic shock is a major cause of death in intensive care. Septic shock is often dominated by profound changes in organ functions, of which cardiac failure is one of the most severe.
- Conditions
- Septic Shock, Left Ventricular Systolic Dysfunction, Left Ventricular Diastolic Dysfunction
- Trial name
- Septic Heart (NCT01747187)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Refractory Heart Failure
Levacor™ Ventricular Assist Device (VAD) Bridge to Transplant Study
The Levacor™ Ventricular Assist Device (VAD) has been designed for mechanical circulatory support in heart failure patients. The purpose of this clinical study is to determine its safety and efficacy as a bridge to transplant…
- Trial name
- NCT01001793
- Testing
- Levacor Ventricular Assist Device
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- World Heart Corporation
Congestive Heart Failure
A Thyroid Hormone Analog to Fight Heart Failure: Phase II Trial (DITPA)
Congestive heart failure (CHF) affects 4-5 million Americans, and its prevalence is predicted to increase over the next few decades.
- Trial name
- NCT00032643
- Testing
- DITPA
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- US Department of Veterans Affairs
Block Complete Heart, Atrial Fibrillation (AF)
Closed-Loop Stimulation in Left Bundle Branch Area Pacing
This prospective, single-center, crossover study evaluated the effects of closed-loop stimulation (CLS) compared with conventional accelerometer-based rate-adaptive pacing (VVIR) in patients with permanent atrial fibrillation…
- Conditions
- Block Complete Heart, Atrial Fibrillation (AF), Chronotropic Incompetence
- Trial name
- NCT07812935
- Testing
- Closed-Loop Stimulation, Accelerometer-Based VVIR Pacing
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Bartlomiej Wrobel
Takotsubo Cardiomyopathy, Sepsis-induced Cardiomyopathy
Characterization of priMary And sEcondary STress Related takOtsubo
Takotsubo syndrome (TTS) is an acute and reversible form of myocardial injury often preceded by a physical or emotional trigger.
- Trial name
- MAESTRO (NCT05793008)
- Testing
- Positron Emission Tomography (PET) analysis, Blood samples collection, Clinical follow up visit
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Coronary Syndrome, Plaque, Atherosclerotic
Prediction of Vulnerable Plaque Using Coronary CT Angiography and Computational Fluid Dynamic in Acute Coronary Syndrome
The aim of the PVCFD trial is to predict vulnerable plaque confirmed by OCT using coronary CT angiography and computational fluid dynamics in patients with acute coronary syndrome.
- Trial name
- PVCFD (NCT04524117)
- Volunteers
- 200 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Artery Disease
Treatment of Coronary De-novo Stenosis by a Sirolimus Coated Balloon or a Paclitaxel Coated Balloon Catheter
To examine the treatment of coronary de-novo stenosis with a sirolimus coated balloon versus a paclitaxel coated balloon
- Trial name
- SCBDENOVO (NCT03908450)
- Testing
- PTCA of coronary de novo lesion PCB, PTCA of coronary de novo lesion SCB
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 70 people
- Sponsor
- InnoRa GmbH
Chagas Disease, Chagas Cardiomyopathy
Cardiac Rehabilitation in Chagas Heart Failure
Due to the lack of information in the literature about the role of cardiac rehabilitation on Chagas heart failure, the aim of the present study was to evaluate the effects of a cardiac exercise program on functional capacity…
- Trial name
- NCT02516293
- Testing
- Exercise, nutritional and pharmaceutical counseling
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Systolic Heart Failure, Ventricular Premature Complexes
Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure.
- Conditions
- Systolic Heart Failure, Ventricular Premature Complexes, Ventricular Tachycardia, Cardiac Resynchronization Therapy
- Trial name
- NCT04065893
- Testing
- Catheter ablation of ventricular arrhythmia, Intensified medical therapy
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Köln
Aortic Stenosis, Transcatheter Aortic Valve Replacement
Transcatheter Aortic Valve Replacement (TAVR) Effects on Cardiac Conduction System
This is a prospective observational study, the purpose of which is to: 1. Characterize response of the AV conduction system to TAVR with various prostheses by recording continuous His bundle electrograms during valve placement.
- Conditions
- Aortic Stenosis, Transcatheter Aortic Valve Replacement, Heart Block
- Trial name
- TAVR-HBE (NCT04982406)
- Testing
- Transcatheter aortic valve replacement
- Where
- United States
- Volunteers
- 409 people
- Sponsor
- Beth Israel Deaconess Medical Center
Homebased Cardiac Rehabilitation Program After Ischemic Heart Disease
Homebased Monitoring Cardiac Rehabilitation Program
The current state of mobile communication and technology is a tool to support home programs for chronic disease management, useful to facilitate access to these types of programs, because the investigators could obtain telematics…
- Trial name
- NUUBO (NCT02796404)
- Testing
- Homebased cardiac rehabilitation program, Traditional cardiac rehabilitation program
- Where
- 3 sites in Spain
- Volunteers
- 148 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Coronary Artery Disease, Human Immunodeficiency Virus (HIV)
Pericardial Fat and Inflammation in HIV Patients and Controls
The investigators propose to correlate 1) cardiac MRI pericardial adipose volume, 2) the presence of pericardial monocytes and 3) circulating immune biomarkers in persons with and without CHD and HIV infection compared to…
- Trial name
- NCT02399384
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Cardiac Failure, Aortic Disease
Cardiac Remodelling Following Endovascular Repair of the Aorta
To assess the effects of endovascular aortic repair on cardiac morphology and function
- Trial name
- EVACaRe (NCT07415447)
- Testing
- cardiac magnetic ressonance
- Where
- 2 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Heart Disease, Neurocognitive Decline
Continuous Cellsaver and Neurocognitive Decline Post Cardiac Surgery
Patients having cardiac surgery to correct their heart disease may suffer a decline in mental and neurologic abilities. Passage of small particles of fat, tissue waste and air bubbles to the brain while on the heart-lung machine…
- Trial name
- NCT00296985
- Testing
- Fresenius Cellsaver
- Where
- Canada
- Volunteers
- 312 people
- Sponsor
- University Health Network, Toronto
Acute Coronary Syndrome
Long-term Follow-up of Health Related Quality of Life in Patients With Acute Coronary Syndrome
This study is aiming to i)measure longterm health related quality of life (HRQL) outcomes of the EMMACE3 patients hospitalised with acute coronary syndromes (ACS) and evaluate possible associations with their cardiovascular…
- Trial name
- EMMACE-3X (NCT01955525)
- Where
- United Kingdom
- Volunteers
- 3,500 people
- Sponsor
- University of Leeds
Heart Failure, Muscle Atrophy
A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure
Severe skeletal wasting and catabolic weight loss are highly common among patients with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- ASTRID-HF (NCT05627440)
- Testing
- Ensure Max Protein, Ensure Original
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Tufts Medical Center
Heart Failure
Heart Failure Self-care Mobile Application to Reduce Readmissions Trial
This is a patient-centered comparative effectiveness feasibility pilot designed to examine an intervention to increase heart failure self-care and symptom recognition.
- Trial name
- HF-SMART (NCT03982017)
- Testing
- Mobile Health Technology Platform, Usual care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Prospective Evaluation of Flare Detection in IBD With Digital Biomarkers: Bring Your Own Device Study
The aim of this study is to identify HRV changes predictive of IBD flares using patient-own wearable devices in a large cohort supplemented by additional data layers including sleep parameters, step count and clinical data…
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- BYOD (NCT07647640)
- Testing
- Wearing their own wearable device.
- Where
- 3 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Maastricht University Medical Center
Refractory Angina Pectoris
Extracorporeal Shock Wave Therapy for the Treatment of Ischemic Heart Disease
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with…
- Trial name
- NCT01241968
- Testing
- Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Medispec
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