Clinical trials: Heart Failure, Reduced Ejection Fraction
Sudden Cardiac Death, Sudden Cardiac Arrest
Heart Failure Optimization Study
This study is designed as a multi-center prospective observational study of newly diagnosed Heart Failure (HF) patients to test the hypothesis that additional Ejection Fraction (EF) recovery occurs between 90 and 180 days as…
- Conditions
- Sudden Cardiac Death, Sudden Cardiac Arrest, Heart Failure, Heart Failure Low Output
- Trial name
- HF-Opt (NCT03016754)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 67 sites in United States, Austria and 2 more
- Volunteers
- 602 people
- Sponsor
- Zoll Medical Corporation
Heart Failure
Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
The purpose of this study is to determine if treatment with omecamtiv mecarbil when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in…
- Trial name
- GALACTIC-HF (NCT02929329)
- Testing
- Omecamtiv Mecarbil, Standard of Care
- Where
- 1,033 sites in United States, Argentina and 34 more
- Volunteers
- 8,256 people
- Sponsor
- Cytokinetics
Chronic Heart Failure, Chronic Heart Failure With Reduced Ejection Fraction
An Observational Study to Learn More About the Real-world Outcomes in Patients With Heart Failure Who Initiate Treatment With Vericiguat in Japan
This is an observational study in which data already collected from people with chronic heart failure is studied. Chronic HFrEF is a long-term condition where the left side of the heart does not pump blood out to the body as well…
- Trial name
- ROVER Japan (NCT06697353)
- Testing
- vericiguat (BAY 1021189)
- Where
- Japan
- Volunteers
- 4,936 people
- Sponsor
- Bayer
Heart Failure, Heart Failure and Reduced Ejection Fraction
Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fraction With Limited Kidney Function Assessments
Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) constitutes of four medications that substantially reduce morbidity and mortality, and improve quality of life.
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction
- Trial name
- RESUME-HF (NCT07275437)
- Testing
- Blinded kidney function assessments
- Where
- 2 sites in Netherlands
- Volunteers
- 344 people
- Sponsor
- University Medical Center Groningen
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Systolic Heart Failure
GutHeart: Targeting Gut Microbiota to Treat Heart Failure
The objective of this trial is to study the effect of targeting the gut microbiota in patients with heart failure (HF). First, the investigators will characterize gut microbiota composition in patients with various degree of…
- Trial name
- NCT02637167
- Testing
- Rifaximin, Saccharomyces boulardii
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
Cardiovascular Diseases, Anemia, Iron-deficiency
Iron in Patients With Cardiovascular Disease
It is now recognized that iron deficiency in cardiovascular disease contributes to impaired clinical outcome.
- Conditions
- Cardiovascular Diseases, Anemia, Iron-deficiency, Acute Myocardial Infarction, Atrial Fibrillation
- Trial name
- iCHF-2 (NCT03991000)
- Testing
- Ferric carboxymaltose, Saline
- Where
- 3 sites in Germany
- Volunteers
- 8 people
- Sponsor
- Dr. med. Mahir Karakas
Heart Failure With Reduced Ejection Fraction
Efficacy and Safety of Lactoferrin in Heart Failure Patients
This study will be conducted to determine the efficacy and safety of lactoferrin versus oral iron versus lactoferrin plus oral iron as an add on therapy in reduced ejection fraction heart failure patients with iron deficiency.
- Trial name
- NCT06427200
- Testing
- oral Iron, Lactoferrin, lactoferrin and oral iron
- Volunteers
- 114 people
- Sponsor
- Cairo University
Heart Failure, Systolic, Sudden Cardiac Death
Prediction of Mortality After CIED Implantation (PM-CIED)
The study aims to develop and validate predictive models for the mortality of patients receiving CIED (including CRT and ICD) implantation.
- Trial name
- PM-CIED (NCT05396313)
- Testing
- CRT/ICD
- Where
- China
- Volunteers
- 1,618 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure With Reduced Ejection Fraction, Heart Failure
Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure
In a randomized, double-blind, placebo-controlled cross-over design, subjects will either receive a supplemental drink containing a commercially available ketone ester (DeltaG®, 500 mg/kg body weight), or a taste matched…
- Trial name
- KETONE-HF (NCT05348460)
- Testing
- Ketone ester drink (DeltaG®, 500 mg/kg body weight)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
HFrEF - Heart Failure With Reduced Ejection Fraction
Electronic Medical Record Alerts to Optimize Medical Therapy in Heart Failure and Reduced Ejection Fraction
OPTIMAL-HF is a pragmatic, cluster randomized, single-blind intervention trial that will be conducted at an outpatient clinic in Argentina.
- Trial name
- OPTIMAL-HF (NCT06166823)
- Testing
- EMR alert
- Volunteers
- 240 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Heart Failure With Reduced Ejection Fraction HFrEF
Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure
In patients with HF cardiac output, metabolism and endothelial function will be studied during and after treatment with ghrelin infusion
- Trial name
- MetAnEnd-HF (NCT05277415)
- Testing
- Ghrelin
- Volunteers
- 31 people
- Sponsor
- Lars Lund
Heart Failure
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
The purpose of this registry (NCT02880618) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO System in the commercial setting in subjects recently implanted under the CE-Marked indication for heart failure with…
- Trial name
- HFrEF (NCT02880618)
- Testing
- Barostim Neo™ System
- Where
- 30 sites in Germany, Italy
- Volunteers
- 500 people
- Sponsor
- CVRx, Inc.
Heart Failure; With Decompensation, Cardiorenal Syndrome
The Aortix CRS Pilot Study
The Aortix CRS Pilot Study: An Evaluation of the Safety and Performance of the Aortix System for Intra-Aortic Mechanical Circulatory Support in Patients with Cardiorenal Syndrome
- Conditions
- Heart Failure; With Decompensation, Cardiorenal Syndrome, Cardio-Renal Syndrome, Heart Failure
- Trial name
- NCT04145635
- Testing
- Aortix System
- Where
- 19 sites in United States, Australia
- Volunteers
- 21 people
- Sponsor
- Procyrion
Heart Failure With Reduced Ejection Fraction
PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction
This study is trying to find out whether performing a hybrid aerobic-resistance exercise training program (titled PRIME: Peripheral Remodeling via Intermittent Muscular Exercise) results in better health outcomes than the…
- Trial name
- NCT05609097
- Testing
- PRIME, COMBO
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Virginia
Chronic Heart Failure, Sleep Disorder
The Epidemiology of Sleep Disordered Breathing in Patients With Congestive Heart Failure
This research will be one of the first hospital-based studies to comprehensively evaluate the epidemiological characteristics of sleep disordered breathing (SDB) in patients with Congestive Heart Failure (CHF).
- Trial name
- NCT05332223
- Testing
- Full Polysomnography
- Where
- Malaysia
- Volunteers
- 116 people
- Sponsor
- Ministry of Health, Malaysia
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Chronic Systolic Heart Failure
Clinical Trial of Systolic Heart Failure Treatment of IvabRadine Hemisulfate Sustained-release Tablets （FIRST）
Ivabradine acts by inhibiting the ionic If current that modulates the pacemaker activity of sinoatrial node cells. The aim of present study is to evaluate the efficacy and safety of IvabRadine hemisulfate Sustained-release…
- Trial name
- FIRST (NCT02188082)
- Testing
- IvabRadine hemisulfate Sustained-release Tablets
- Where
- 12 sites in China
- Volunteers
- 336 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Heart Failure, Systolic
Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure
The main purpose of this study is to determine whether dietary nitrate supplementation via concentrated beetroot juice improves central and peripheral cardiovascular control and physical capacity in patients with systolic heart…
- Trial name
- NCT02401126
- Testing
- Nitrate supplementation
- Volunteers
- 13 people
- Sponsor
- Queen's University