Clinical trials: Heart Failure, Reduced Ejection Fraction
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Heart Failure With Reduced Ejection Fraction
The ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI
A prospective, single centre, observational cohort study at University Hospital Southampton NHS Foundation Trust of 50 consecutive patients with Heart Failure with reduced Ejection Fraction and Ejection Fraction ≤35% who are…
- Trial name
- ENVI (NCT05348226)
- Testing
- Additional Cardiac Magnetic Resonance Scan
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure
Predictors of an Unfavorable Outcome in Patients With Heart Failure
The subject of the study is the factors of unfavorable prognosis in heart failure. We would like to identify independent variables associated with a bad prognosis of patients hospitalized for heart failure with a reduced vs.
- Trial name
- NCT04753814
- Testing
- Diagostic tests
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Heart Failure, Systolic
Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of ITI-214 in Patients With Heart Failure
This is a Phase I/II randomized, double-blind, placebo-controlled, single rising dose study in patients with systolic heart failure to evaluate the safety and tolerability of ITI-214.
- Trial name
- NCT03387215
- Testing
- ITI-214
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Heart Failure With Reduced Ejection Fraction
Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure
Prospective, multi-center, open-label clinical study of the feasibility and initial safety and performance of the Vsling™ in patients with heart failure (HF) with evidence of reduced left ventricular ejection fraction, associated…
- Trial name
- NCT06851949
- Testing
- Vsling
- Where
- 5 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Cardiac Success
Heart Failure, Systolic
Digital Remote Home Monitoring for Heart Failure
We will enroll 150 adult participants with systolic heart failure into the ADHERE-HF trial. The study will randomize participants in a 1:2 fashion to usual care or usual care plus the American Heart Association's Digital Solution…
- Trial name
- ADHERE-HF (NCT05988749)
- Testing
- Biofourmis Digital Platform
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure, Reduced Ejection Fraction
Effects of Virtual Reality on Rehabilitation in Patients With Heart Failure
Background. To improve symptoms and reduce poor outcomes related to heart failure (HF), international guidelines recommend cardiac rehabilitation (CR), particularly for those with a reduced ejection fraction.
- Trial name
- VIRTUAL-HF (NCT06115928)
- Testing
- Virtual reality
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Valentina Micheluzzi
Hearth Failure With Reduced Ejection Fraction (HFrEF), Cardiac Resynchronisation Therapy (CRT)
THE RELATIONSHIP BETWEEN CARDIAC RESYNCHRONİZATION THERAPY RESPONSE IN HEART FAILURE PATIENTS AND YKL-40 LEVELS
Patients diagnosed with heart failure at our clinic who routinely undergo CRT implantation will be included in the study. This decision is independent of the study.
- Conditions
- Hearth Failure With Reduced Ejection Fraction (HFrEF), Cardiac Resynchronisation Therapy (CRT), Left Branch Bundle Block
- Trial name
- NCT07469137
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Trakya University
Heart Failure, Systolic
Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation
Cardiac resynchronisation therapy (CRT) improves outcomes and symptoms in selected patients with heart failure. However, around one third of suitable patients do not demonstrate benefit following device implantation when assessed…
- Trial name
- QUARTRMASTER (NCT02997670)
- Testing
- Algorithmic Cardiac Resynchronisation Therapy Optimisation
- Where
- United Kingdom
- Sponsor
- Cardiff and Vale University Health Board
Chronic Systolic Heart Failure
Study of Efficacy on Cardiac Remodeling of Recombinant Human Neuregulin-1 in Stable Chronic Systolic Heart Failure Patients
This is a multi-center, randomized, double-blind , placebo parallel controlled, standard therapy based phase III clinical trial, to evaluate the efficacy of recombinant human neuregulin-1 on cardiac remodeling, as well as safety…
- Trial name
- NCT01439893
- Testing
- rhNRG-1
- Where
- 4 sites in China
- Volunteers
- 14 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Hyperkalaemia, Heart Failure with Reduced Ejection Fraction
Hyperkalaemia and Its Impact on Therapy with RAASi
Renin-angiotensin-aldosterone system inhibitors (RAASi) have transformed prognosis of patients with heart failure with reduced ejection fraction, diabetic nephropathy and chronic kidney disease.
- Conditions
- Hyperkalaemia, Heart Failure with Reduced Ejection Fraction, Left Ventricular Systolic Dysfunction
- Trial name
- REVIEW (NCT04249648)
- Where
- United Kingdom
- Volunteers
- 651 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Heart Failure, Heart Failure With Preserved Ejection Fraction
Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program
This is a pilot randomized trial of the BAMS-HF (Balance, Aerobic capacity, Mobility and Strength in patients hospitalized for Heart Failure) Program versus usual care.
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure, Systolic, Heart Failure, Diastolic
- Trial name
- BAMS-HF (NCT04281849)
- Testing
- BAMS-HF Program
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Eastern Colorado Health Care System
Heart Failure, Systolic
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure
Pathological cardiac hypertrophy is characterized by abnormal cardiomyocyte metabolism, reduced myocardial contractility, and dysregulated synthesis of myocardial contractile proteins.
- Trial name
- NCT07050706
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Heart Failure, Systolic
Hypoxic Conditioning in Heart Failure
Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe
- Trial name
- hypoxheart (NCT03537079)
- Testing
- hypoxia air
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble
Heart Failure With Reduced Ejection Fraction (HFrEF)
The Effectiveness of Collaborative Health Management Model on Heart Failure Patient
The purpose of this study is to explore the effect of the collaborative health management model on the functional status, quality of life and rehospitalization rate of patients with heart failure. This is a three-year project.
- Trial name
- NCT04860596
- Testing
- collaborative health management model
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antai Medical Care Corperation Antai Tian-Sheng Memorial Hospital/ Department of Nursing/National Ta
Acute Heart Failure (AHF), Acute Heart Failure With Reduced Ejection Fraction
Vietnamese Rapid Acceleration Protocol for Intensifying Drug Therapy in Heart Failure With Reduced Ejection Fraction
VN-RAPID is an open-label, multicenter, randomized controlled trial evaluating the safety and efficacy of in-hospital initiation and rapid up-titration of four-pillar therapy for hospitalized Asian patients with acute heart…
- Trial name
- VN-RAPID (NCT06595290)
- Testing
- High intensity care, Usual care
- Where
- 4 sites in Vietnam
- Volunteers
- 500 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Chronic Heart Failure With Reduced Ejection Fraction
A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Participants With Chronic Heart Failure With Reduced Ejection Fraction
The purpose of this study is to evaluate the effect of IONIS-AGT-LRX weekly subcutaneous (SC) injection on plasma angiotensinogen (AGT) concentration from Baseline to Study Day 85 (Week 13) and to evaluate the effect of…
- Trial name
- ASTRAAS-HF (NCT04836182)
- Testing
- IONIS-AGT-LRx
- Where
- 19 sites in United States, Hungary and 1 more
- Volunteers
- 72 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Acute Heart Failure
Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation
The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure.
- Trial name
- AHF-CODE-R (NCT04343443)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Biological: Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Systolic, Heart Failure; With Decompensation
Fluid Restriction in Patients With Heart Failure
There is a concept increasingly consolidated by clinical evidence that at each hospitalization due to HF decompensation there is a substantial loss of quality of life, which is associated with an initial period of great clinical…
- Conditions
- Heart Failure, Systolic, Heart Failure; With Decompensation, Pulmonary Congestion
- Trial name
- NCT04611594
- Testing
- Fluid restriction
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure With Reduced Ejection Fraction
Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study
The overall aim of this project is to evaluate the effects of a digital support program for patients with heart failure through a cluster-randomized controlled trial, and to investigate the outcomes of different implementation…
- Trial name
- NCT07275931
- Testing
- Tailored implementation support
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University