Clinical trials: Heart Failure, Systolic
Dyspnea, Heart Failure
Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)
The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.
- Trial name
- NCT03831204
- Testing
- biopac, prognostic scores
- Where
- Tunisia
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Systolic Heart Failure
Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been used safely in humans for decades for this and other indications.
- Trial name
- ReProsperHF (NCT01814319)
- Testing
- Probenecid 1 gr oral twice daily
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Diastolic Heart Failure
If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure
The purpose of this study is to investigate whether the medicine ivabradine, a novel drug which slows the heart rate has a favourable effect on patients with diastolic heart failure.
- Trial name
- NCT00757055
- Testing
- Ivabradine
- Where
- Ireland
- Sponsor
- St Vincent's University Hospital, Ireland
Heart Failure, Heart Failure, Systolic
Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure
Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF.
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Transplantation
- Trial name
- TRUE-HF (NCT05008692)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Heart Failure and Reduced Ejection Fraction
Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fraction With Limited Kidney Function Assessments
Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) constitutes of four medications that substantially reduce morbidity and mortality, and improve quality of life.
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction
- Trial name
- RESUME-HF (NCT07275437)
- Testing
- Blinded kidney function assessments
- Where
- 2 sites in Netherlands
- Volunteers
- 344 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Systolic Heart Failure
Heart Failure (HF) Outpatient Monitoring Evaluation (HOME) Study
The purpose of this study is to determine if heart failure subjects whose treatment is assisted by home BNP measurements integrated into a home health management system will have better clinical outcomes than subjects whose…
- Conditions
- Heart Failure, Systolic Heart Failure, Acute Decompensated Heart Failure
- Trial name
- HOME (NCT01347567)
- Testing
- Interventions with heart failure medications
- Where
- 7 sites in Australia, Ireland and 4 more
- Volunteers
- 145 people
- Sponsor
- Alere San Diego
Heart Failure and Reduced Ejection Fraction, Heart Failure
PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure
Background: Heart failure with reduced ejection fraction (HFrEF) is a heterogeneous condition with variable potential for left ventricular ejection fraction (LVEF) recovery.
- Trial name
- PRIMA-HF (NCT07243119)
- Testing
- HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Gødstrup Hospital
Heart Failure, Left Ventricular (LV) Systolic Dysfunction
AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)
This prospective observational study (ECHO-FIT Study) aims to develop and validate a predictive model for cardiac function, particularly left ventricular ejection fraction (LVEF), by integrating echocardiographic measurements…
- Conditions
- Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Body Composition Measurement, Artificial Intelligence (AI)
- Trial name
- ECHO-FIT (NCT06811519)
- Testing
- Body Composition Analyzer (ACCUNIQ BC720)
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Systolic Heart Failure, Myocardial Disease
Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy
Accumulated clinical and experimental data suggest that dysfunctional coronary microcirculation plays a pivotal role in the progression of heart failure despite an optimal therapy used.
- Conditions
- Systolic Heart Failure, Myocardial Disease, Cardiomyopathy
- Trial name
- NCT00348530
- Testing
- Verapamil
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Angina Pectoris, Acute Coronary Syndrome
Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19
Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure…
- Conditions
- Angina Pectoris, Acute Coronary Syndrome, Coronary Syndrome, Coronary Artery Disease
- Trial name
- eCardioCovid19 (NCT04325867)
- Testing
- Tele-medicine platform
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic
Systolic Heart Failure
GutHeart: Targeting Gut Microbiota to Treat Heart Failure
The objective of this trial is to study the effect of targeting the gut microbiota in patients with heart failure (HF). First, the investigators will characterize gut microbiota composition in patients with various degree of…
- Trial name
- NCT02637167
- Testing
- Rifaximin, Saccharomyces boulardii
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
Assessment of the RV Function in Patients With Heart Faliure
Right Ventricular Function in Heart Failure
Only a few studies evaluated the RV systolic function in the three categories of HF, regarding the importance of understanding changes in RV function on clinical presentation and outcome; it was essential to understand the…
- Trial name
- NCT03641599
- Testing
- echocardiography
- Volunteers
- 150 people
- Sponsor
- shaimaa Mostafa
Multiple Myeloma, Heart Failure, Systolic
Evaluation of Cardiotoxic Effects of Bortezomib
The purpose of this study is to learn more about how a drug commonly used to treat multiple myeloma can affect the heart. In this study, the investigators will learn whether a drug called how a drug (called bortezomib, or…
- Conditions
- Multiple Myeloma, Heart Failure, Systolic, Cardiotoxins
- Trial name
- NCT02026505
- Testing
- Bortezomib
- Volunteers
- 11 people
- Sponsor
- Oregon Health and Science University
Chronic Systolic Heart Failure
Clinical Trial of Systolic Heart Failure Treatment of IvabRadine Hemisulfate Sustained-release Tablets （FIRST）
Ivabradine acts by inhibiting the ionic If current that modulates the pacemaker activity of sinoatrial node cells. The aim of present study is to evaluate the efficacy and safety of IvabRadine hemisulfate Sustained-release…
- Trial name
- FIRST (NCT02188082)
- Testing
- IvabRadine hemisulfate Sustained-release Tablets
- Where
- 12 sites in China
- Volunteers
- 336 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Heart Failure
A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study
The purpose of this open-label study was to collect additional safety information of sacubitril/valsartan and to provide post-trial access to sacubitril/valsartan for the eligible Japanese patients who completed…
- Trial name
- NCT06149104
- Testing
- sacubitril/valsartan
- Where
- 6 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Systolic, Heart Failure NYHA Class IV
Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure
Preliminary animal studies by ourselves and others suggest that the dietary supplement, nicotinamide riboside (NR), may improve cardiac function in heart failure (HF) by increasing cellular levels of its metabolite, nicotinamide…
- Conditions
- Heart Failure, Systolic, Heart Failure NYHA Class IV, Metabolic Disturbance
- Trial name
- NRII (NCT04528004)
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Washington
Heart Failure, Systolic, Financial Stress
Financial Support in an Underserved and Low-Income Population With Heart Failure
The goal of this clinical trial is to test whether financial support in the form of a one-time $500 stipend would improve medication adherence and quality of life in low-income, socially-needy patients with heart failure with…
- Conditions
- Heart Failure, Systolic, Financial Stress, Medication Adherence, Quality of Life
- Trial name
- FUND-HF (NCT05928026)
- Testing
- Financial Support
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Heart Failure, Systolic
R-wave Optimisation in Cardiac Resynchronisation Therapy Study
The aim of this study is to investigate whether the use of a simple feature on the 12 lead electrocardiogram (ECG) to optimise pacemaker device programming can have clinically relevant benefit to patient management.
- Trial name
- NCT02080000
- Testing
- Optimisation of V-V timing using R wave on surface ECG, Standard V-V timing settings
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- The Royal Bournemouth Hospital