Clinical trials: Heart Failure, Unspecified
Heart Failure With Reduced Ejection Fraction, Heart Failure
STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure
This is a multicenter, randomized, open-label pilot study to evaluate whether stepwise withdrawal of two heart failure medications-angiotensin receptor-neprilysin inhibitor (ARNI) and sodium-glucose cotransporter-2 inhibitor…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure, Ventricular Dysfunction, Left
- Trial name
- STEP-DOWN HF (NCT07631156)
- Testing
- Stepwise Withdrawal of ARNI and SGLT2i, Continued Guideline-Directed Medical Therapy
- Where
- 5 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Kyungsub Song
Heart Failure With Preserved Ejection Fraction, Diabete Type 2
The Effect of Addition of Metformin to SGLT2 In Diabetic Patients With Heart Failure With Preserved Ejection Fraction
a prospective open-label, randomized controlled study to evaluate the efficacy of the addition of metformin to SGLT2 in diabetic patient with preserved ejection fraction
- Trial name
- NCT06080802
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- October University for Modern Sciences and Arts
Heart Failure
Targeted Left Ventricular Lead Placement, Comparison of Active Fixation Bipolar and Passive Quadripolar Pacemaker Leads
A prospective, randomized and patient-blinded trial comparing an active fixation left ventricular lead with quadripolar passive left ventricular leads.
- Trial name
- NCT04632472
- Testing
- Active fixation bipolar lead versus passive fixation quadripolar leads in Cardiac Resynchronization Therapy
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- Haukeland University Hospital
Mitral Regurgitation, Mitral Valve Disease
LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY
Mitral valve leakage, or mitral regurgitation (MR), is associated with heart failure symptoms including shortness of breath, fatigue, irregular heart rate. When left untreated, it may cause death.
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Heart Failure
- Trial name
- LAMBDA (NCT06547788)
- Testing
- Mitral valve repair with creation of an 8 mm inter-atrial shunt
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Tachyarrhythmias, Sudden Cardiac Death
SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients
The purpose of this study is to characterize the chronic performance of the St. Jude Medical SJ4 connector and RV high voltage SJ4 leads.
- Conditions
- Tachyarrhythmias, Sudden Cardiac Death, Heart Failure
- Trial name
- NCT00940888
- Testing
- SJ4 connector and RV high voltage SJ4 lead
- Where
- United States
- Volunteers
- 1,701 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Remote Consultation, Teleconsultation
Comparison Between a Robotic Tele-echo-cardiography Technique and a Standard Echocardiography in the Management of Heart Failure in the Guadeloupe Archipelago Between the University Hospital of Guadeloupe and the Marie-Galante Hospital
The TERdeblue-S study is a feasibility study of robotic remote echocardiography, not only in terms of technology but also in terms of its integration into a telemedicine system to improve access to the heart failure management…
- Conditions
- Heart Failure, Remote Consultation, Teleconsultation, Echocardiography, Doppler
- Trial name
- TER de blueS (NCT07265986)
- Testing
- in situ echocardiography (EIS), two-dimensional remote echocardiography (TER)
- Where
- 3 sites in Guadeloupe
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Heart Failure, Heart Failure With Preserved Ejection Fraction
PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study
This is a prospective multicenter study to decipher phenotypic variability within patients with heart failure and preserved left ventricular ejection fraction (HFpEF).
- Trial name
- NCT04189029
- Testing
- Extensive phenotyping
- Where
- France
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Clinical Evaluation Of The SonR Atrial Lead In Paradym RF Device
Sorin Group has developed a new atrial lead which is under evaluation during this study. The SonR atrial lead presents a new sensor in the tip of the lead and allows a new feature; interventricular (VV) and atrioventricular (AV)…
- Trial name
- NCT01169272
- Testing
- CRT-SonR 9770
- Where
- France
- Volunteers
- 100 people
- Sponsor
- LivaNova
Heart Failure, Diabetes Mellitus
Remote Multichannel Monitoring of Patients With Chronic DIseAses Using Speech technoLogies Based On Artificial intelliGence
DIALOG is a study to assess the efficacy and safety of remote patient monitoring using virtual operator voice technologies and a business intelligence (BI) system for timely detection, prevention of early complications, worsening…
- Conditions
- Heart Failure, Diabetes Mellitus, Arterial Hypertension, Lymphoproliferative Disease
- Trial name
- DIALOG (NCT06644339)
- Testing
- Voice assistant
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Failure
Determine Return on Investment in Heart Failure Remote Monitoring Program
The study will test a hypothesis that the remote monitoring with text and email alerts sent to study subject and optional family/other caregiver (Intervention 1) will have a higher return on investment compared to remote…
- Trial name
- NCT02475577
- Testing
- Peripherals with HealthInterlink technology
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH
Heart Failure, Heart Failure With Reduced Ejection Fraction
Consistently Assess Signs and Symptom of Heart Failure
Heart failure (HF) is a major public health problem. The New York Heart Association (NYHA) Functional Classification by a HF provider helps to guide their decisions in patient treatment.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- CLASS-HF (NCT05833581)
- Testing
- New York Heart Association Classification Guide
- Where
- 3 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Board of Trustees of Illinois State University
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Iron-deficiency, Heart Failure
Effect of IV Iron in Patients With Heart Failure With Preserved Ejection Fraction
This study addresses, whether treatment with IV iron for patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency (ID), both with or without anaemia, can improve exercise capacity as measured by…
- Trial name
- FAIR-HFpEF (NCT03074591)
- Testing
- Ferric Carboxymaltose 50Mg/Ml Inj 15Ml, Saline Solution for Injection
- Where
- 7 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Cardiomyopathy, Dilated, 3B
CRT-P or CRT-D in Dilated Cardiomyopathy
The ICD-Reality study is a non-commercial, investigator-led, multicenter, prospective, randomized, controlled trial. We aim to determine the effect of CRT-D or CRT-P implantation in non-ischemic cardiomyopathy and heart failure…
- Trial name
- CRT-REALITY (NCT04139460)
- Testing
- CRT-D, CRT-P
- Where
- Czechia
- Volunteers
- 924 people
- Sponsor
- University Hospital Olomouc
Heart Failure With Reduced Ejection Fraction, Nonischemic Cardiomyopathy
Gut Microbiome Profiling in Patients With Chronic Heart Failure
The goal of this observational study is to learn about the composition and function of the gut microbiome in adults with chronic heart failure with reduced ejection fraction. The main questions the study aims to answer are: 1.
- Trial name
- NCT06361524
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
HEART DISEASE, Liver Failure
Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic
Alcohol abuse is associated with a variety of clinical diseases, but studies on prevalence of different somatic diseases among alcohol abusers are lacking. Studies on populations in an out-day patients' clinic are also lacking.
- Conditions
- HEART DISEASE, Liver Failure, DEPRESSIVE DISORDER, Alcoholic Neuropathy
- Trial name
- NCT01081197
- Testing
- Psychiatric and somatic examinations and ,if clinical indicated, treatment
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Helse Nord-Trøndelag HF
Heart Failure
The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure
Our proposed research will examine whether treatment with simvastatin alters expression and activity of monocyte TF, whether polymorphisms in the TF gene alter the therapeutic effect and what effect treatment has on inflammatory…
- Trial name
- NCT00769210
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Heart Failure, Ventricular Function, Left
Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
Exercise is essential in cardiac rehabilitation for heart failure patients.Aerobic training and resistance training are both recommended.
- Trial name
- ERFOCARD (NCT07118410)
- Testing
- Application of a vascular restriction device during resistance training
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Failure, Ventricular Arrythmia
ASCEND CSP IDE Study
This is a prospective, multi-center, global, single-arm, pivotal investigational study designed to evaluate the safety and effectiveness of the CSP ICD Lead in a subject population indicated for ICD or CRT-D therapy.
- Trial name
- ASCEND CSP IDE (NCT06830746)
- Testing
- LBBAP Implant with a CSP ICD Lead
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 414 people
- Sponsor
- Abbott Medical Devices
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