Clinical trials: Heart Failure, Unspecified
Heart Failure, Heart Failure, Systolic
Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
It is a randomized prospective controlled study of transcatheter renal denervation in patients with systolic heart failure secondary to Chagas' disease.
- Conditions
- Heart Failure, Heart Failure, Systolic, Chagas Disease, Chagas Cardiomyopathy
- Trial name
- NCT02099903
- Testing
- transcatheter renal denervation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- InCor Heart Institute
Pleural Effusion, Pleural Diseases
Strategy for Prompt and Effective Thoracentesis in the Emergency Department
The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region.
- Conditions
- Pleural Effusion, Pleural Diseases, Heart Failure
- Trial name
- SPEEDTAP (NCT06180603)
- Testing
- Gravity fluid drainage in the radiology department, Manual drainage in the emergency department
- Where
- 6 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus
Heart Failure
Food Supplementation Delivered Conditionally vs Not Among Patients With Heart Failure
The current study proposes to investigate if the provision of healthy food can improve outcomes following discharge after HF hospitalization.
- Trial name
- FOOD-HF (NCT06115369)
- Testing
- Medically Tailored Meals Delivered Conditionally, Medically Tailored Meals Delivered Unconditionally, Produce Boxes delivered Conditionally
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Heart Failure With Preserved Ejection Fraction
Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
The primary hypothesis in this trial is that the treatment with vericiguat 10 mg or 15 mg in patients with HFpEF improves the KCCQ PLS (Kansas City Cardiomyopathy Questionnaire Physical limitation score) compared to placebo after…
- Trial name
- VITALITY-HFpEF (NCT03547583)
- Testing
- Vericiguat (BAY1021189) 2.5 mg, 5 mg or 10 mg IR tablets
- Where
- 177 sites in United States, Argentina and 19 more
- Volunteers
- 789 people
- Sponsor
- Bayer
Heart Failure, Sleep Apnea Syndromes
ECG Derived Respiration for Automated Screening of Sleep Disordered Breathing in Chronic Heart Failure Patients
The prevalence of sleep disordered breathing (SDB) reaches more than 50% in chronic heart failure patients (CHF). The main consequence is an increase risk of fatal and non-fatal cardiovascular events.
- Conditions
- Heart Failure, Sleep Apnea Syndromes, Polysomnography
- Trial name
- NCT02116686
- Testing
- ventilatory polygraphic recordings
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure, Congestive
Renal Effects of Intrarenal Nesiritide
The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation leads to adverse consequences even if the direct renal effects are positive.
- Trial name
- NCT00270829
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
Heart Failure
Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management
The purpose of this study is to evaluate and compare the effectiveness of the HeartMate II (HM II) Left Ventricular Assist Device (LVAD) support versus OMM in ambulatory NYHA Class IIIB/IV heart failure patients who are not…
- Trial name
- ROADMAP (NCT01452802)
- Testing
- HM II (HeartMate II LVAD), OMM (Optimal Medical Management)
- Where
- 52 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Cardiomyopathy
Intracoronary Transplantation of Bone Marrow Derived Mononuclear Cells in Pediatric Cardiomyopathy
According to the high morbidity and mortality of idiopathic Dilated CardioMyopathy (IDCM) in pediatric, new modality of treatment is emerging. There are some case reports of administration of stem cell therapy.
- Trial name
- NCT02256501
- Testing
- Mono Nuclear Cell (MNC) transplantation
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Nasser Aghdami MD., PhD
Chronic Heart Failure, Iron Deficiency
Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN
This study will address whether the additional use of Intravenous (IV) iron on top of standard care will improve the outlook for patients with heart failure and iron deficiency.
- Conditions
- Chronic Heart Failure, Iron Deficiency, Left Ventricular Systolic Dysfunction
- Trial name
- IRONMAN (NCT02642562)
- Testing
- Ferric Derisomaltose
- Where
- 72 sites in United Kingdom
- Volunteers
- 1,160 people
- Sponsor
- University of Glasgow
Chronic Heart Failure, Coronary Disease
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)
Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be…
- Conditions
- Chronic Heart Failure, Coronary Disease, Dilated Cardiomyopathy
- Trial name
- NCT01139086
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Heart Failure
Evaluation of the Program to Help Return Home Patients Hospitalized for Heart Failure, From Paris Saint-Joseph Hospital
The prevalence of heart failure is very high worldwide is between 1 and 2% in developed countries. The French Federation of Cardiology estimates that a million people are affected in France.
- Trial name
- PRADO_IC2 (NCT04613973)
- Where
- France
- Volunteers
- 633 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Cardiovascular Risk Factor, Atrial Fibrillation
The Study of Men Born in 1943
A random sample a random sample of half of all men born in 1943 and living in the city of Gothenburg, Sweden, have been investigated in 1993 at 50 years of age and will be followed continuously with repeated re-examinations and…
- Conditions
- Cardiovascular Risk Factor, Atrial Fibrillation, Congestive Heart Failure, Sleep Apnea
- Trial name
- NCT03138122
- Where
- Sweden
- Volunteers
- 798 people
- Sponsor
- Sahlgrenska University Hospital
Heart Failure
Characterizing Guideline Adoption and Treatment Quality in Clinical Routine of German HFrEF Care
This was a multicenter, non-randomized, non-interventional cohort study with prospective and retrospective collection of primary data on heart failure with reduced ejection fraction (HFrEF) patient treatment and care following a…
- Trial name
- CONNECT (NCT06004453)
- Testing
- Heart Failure medications
- Where
- 94 sites in Germany
- Volunteers
- 899 people
- Sponsor
- Novartis Pharmaceuticals
Stem Cell Transplantation, Ventricular Dysfunction, Left
The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)
The technique of transplanting progenitor cells into a region of damaged myocardium, termed cellular cardiomyoplasty, is a potentially new therapeutic modality designed to replace or repair necrotic, scarred, or dysfunctional…
- Trial name
- TAC-HFT (NCT00768066)
- Testing
- Autologous human mesenchymal cells (hMSCs), Autologous human bone marrow cells (hBMCs)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Miami
Acute Heart Failure (AHF)
Routine Magnesium Testing and Supplementation in Acute Heart Failure (MAG-HF)
This study is an investigator-initiated, pragmatic, randomized controlled feasibility trial evaluating two strategies for magnesium management in adults hospitalized with acute heart failure (AHF).
- Trial name
- MAG-HF (NCT07906353)
- Testing
- No Routine Magnesium Testing or Supplementation, Routine Magnesium Testing and Supplementation
- Volunteers
- 260 people
- Sponsor
- University of Alberta
Dyspnea
Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement
the gold standard for the diagnostic of acute heart failure is based on clinical, biological (BNP levels) and echocardiographic findings, but still in some cases, the diagnosis is difficult and requires further investigations.
- Trial name
- STA/AHF (NCT02161445)
- Testing
- the acoustic cardiographic parameters were calculated
- Where
- Tunisia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Congestive Heart Failure
Congestive Heart Failure: Causes of Sudden Worsening
The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.
- Trial name
- NCT01081925
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Heart Failure With Intraventricular Conduction Delay
A Combined Transvenous and Epicardial Lead Placement Procedure for Implantation of Cardiac Resynchronization Devices: a Feasibility Study.
Cardiac resynchronization therapy has become one of the cornerstones of the treatment of heart failure. However, a large proportion of patients still fails to this type of therapy.
- Trial name
- NCT02247817
- Testing
- Hybrid CRT-D/P implantation
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Congestive Heart Failure
Cohort of Heart Failure Patients
This is a prospective cohort study of patients with Heart Failure with an eighteen-month follow-up aimed to collect all demographic, clinical, biological and para-clinical data to study population characteristics, assess…
- Trial name
- LOOP-HF (NCT03422991)
- Testing
- Blood sampling and Quality of life questionnaire.
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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