Clinical trials: Heart Failure, Unspecified
Heart Failure
The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
Heart failure (HF) is a chronic condition that is characterized by a weakened and enlarged heart. It typically causes symptoms such as breathlessness and swelling of the legs, and it is a serious illness that shortens life…
- Trial name
- TAPERED-HF (NCT07513883)
- Testing
- Down-titration, Continuation of guideline-directed heart failure therapy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg
Heart Failure
Pressure Variability Study
The purpose of this study is to understand how the pressure in the pulmonary artery changes under different conditions of posture, respiration and exertion.
- Trial name
- APVS (NCT02943941)
- Testing
- Reveal LINQ ICM Cardiac Monitor, taped on the subject's chest rather than inserted in the body.
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Advanced Heart Failure, Left Ventrucular Assist Device
Neuron Specific Enolase in Ventricular Assist Device Recipients
An observational study of neuron specific enolase, as a marker of reperfusion injury, in LVAD recipients before and following VAD implantation.
- Trial name
- NSE-LVAD (NCT01643551)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Atherosclerosis, Heart Failure, Congestive
The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function
The renin angiotensin system (RAS) plays an important physiological and pathophysiological role in the control of blood pressure and plasma volume.
- Conditions
- Atherosclerosis, Heart Failure, Congestive, Hypertension, Myocardial Infarction
- Trial name
- NCT00001629
- Testing
- Angiotensin II type 1 receptor antagonists
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Diabetes Mellitus, Type 2
Efficacy and Safety of Dapagliflozin in Acute Heart Failure
This is a randomized trial of the addition of dapagliflozin to patients with or without type 2 diabetes hospitalized with acute decompensated heart failure (ADHF).
- Trial name
- DICTATE-AHF (NCT04298229)
- Testing
- Dapagliflozin 10 MG, Protocolized Diuretic Therapy
- Where
- 6 sites in United States
- Volunteers
- 240 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, Pulmonary, Heart Failure
The Evaluation and Treatment of Elevated Left-Sided Filling Pressures by Balloon Inflation Within the IVC
In patients with heart failure, elevated filling pressures may contribute to symptoms while not improving cardiac output. The current study is focused on evaluating the relationship between exercise capacity, pulmonary pressures…
- Trial name
- NCT02984631
- Testing
- Preventing pulm HTN during exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cardioflow Technologies, LLC
Heart Failure
Self-management Adherence in Heart Failure Patients
Non-adherence to self-management behaviors is prevalent and accounts for hospital readmissions in heart failure (HF) patients 65 years of age and older.
- Trial name
- PATCH (NCT01964053)
- Testing
- PATCH intervention, Usual care
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- University of Nebraska
Chronic Illness, NYHA Class II-IV Heart Failure
Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF)
Using the MOST framework, factorial pilot design, and an iterative, community-based process, the purpose of this study is to pilot test to further develop and refine a palliative care (PC) intervention addressing pain of Black…
- Trial name
- ADAPT HF (NCT06270875)
- Testing
- ADAPT HF
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Heart Failure
Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)
Heart failure is a serious condition in which the heart's ability to pump blood through the body is impaired, often making a person feel weak or fatigued.
- Trial name
- CARRESS (NCT00608491)
- Testing
- Stepped pharmacologic care, Ultrafiltration
- Where
- 9 sites in United States, Canada
- Volunteers
- 188 people
- Sponsor
- Duke University
Chronic Heart Failure
Optimization of the Ambulatory Monitoring for Patients With Heart Failure by Tele-cardiology
Targeted population: Patients with heart failure causing hospitalization during the last twelve months. Hypothesis: The number of all cause deaths and hospitalizations will be smaller for the Telecardiology group than for the…
- Trial name
- OSICAT (NCT02068118)
- Testing
- Telecardiology program
- Where
- 38 sites in France, Martinique
- Volunteers
- 990 people
- Sponsor
- CDM e-Health
Heart Failure
Effectiveness of a Website and Telemonitoring in Patients With Heart Failure.
The number of people with heart failure is increasing in the western world. Mainly due to better treatment of myocardial infarctions and ageing of the population. The amount of health care workers is unfortunately not increasing.
- Trial name
- NCT01755988
- Testing
- Educational website (in addition to usual care)., Website and interactive platform with telemonitoring.
- Where
- 4 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Ventricular Dysfunction, Left
High-dose Selenium Supplementation in Patients With Left Ventricular Assist
This planned pilot study is a monocentric, prospective, double-blind randomized and placebo controlled clinical study. The SOS-LVAD Trial can be assigned to the clinical Phase III.
- Trial name
- SOS-LVAD (NCT02530788)
- Testing
- Selenium Supplement (sodium selenite)
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- RWTH Aachen University
Primary Cardiomyopathy, Dilated Cardiomyopathy
Risk Stratification in Children and Adolescents With Primary Cardiomyopathy
RIKADA is a prospective study performing systematic family screening including clinical and genetic testing in pediatric patients with primary cardiomyopathy and their first-degree relatives with the aim to facilitate risk…
- Conditions
- Primary Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Noncompaction
- Trial name
- RIKADA (NCT03572569)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- German Heart Institute
Acute Decompensated Heart Failure
A Study to Evaluate Lung Ultrasound as a Method to Measure Changes in Extravascular Lung Water Induced by Positional Changes (LUPE)
This is an exploratory study to evaluate lung ultrasound as a method for measuring extravascular lung water in stabilized patients during hospitalization for ADHF.
- Trial name
- LUPE (NCT03146754)
- Testing
- Methodology
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive
Effect of Positive Airway Pressure Therapy on Hospitalization and Mortality in SDB Patients With Comorbid Chronic Obstructive Pulmonary Disease (COPD) or/and Heart Failure (HF)
The aim of the study is to test the hypothesis that treatment of sleep disordered breathing (SDB) in patients with comorbid chronic obstructive pulmonary disease (COPD) and/or heart failure (HF) with positive airway pressure…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive, Heart Failure
- Trial name
- NCT02923505
- Testing
- polygraphy or polysomnography
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 383 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Atrial Fibrillation, Heart Failure
Diltiazem vs. Metoprolol in the Acute Management of AF in Patients With HFrEF
Atrial fibrillation (AF) is the most common arrhythmia, accounting for one third of all hospital admissions and 1% of all emergency department visits (ED). Approximately 65% of those presenting to the ED with AF are admitted.
- Trial name
- NCT02938260
- Testing
- Metoprolol vs Diltiazem
- Volunteers
- 48 people
- Sponsor
- RaeAnn Hirschy
Heart Failure, Congestive
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism…
- Trial name
- NCT00181259
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mechanical Dyssynchrony, Heart Failure
Evaluating Effects of a Left Bundle Branch Block
A left bundle branch block (LBBB) is related to abnormal cardiac conduction and mechanical asynchrony and is associated with hypertension and coronary artery disease.
- Conditions
- Mechanical Dyssynchrony, Heart Failure, Bundle-Branch Block
- Trial name
- NCT00269659
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Congestive Heart Failure
Breathing Relaxation Exercise Heart Failure
The aim of the study is to determine the effect of breathing and relaxation exercises on dyspnea, fatigue and self-care level in heart failure patients.
- Trial name
- NCT05905627
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- University of Yalova
Heart Failure, Obesity
BMI-Driven Tolerability and Efficacy of Entresto in Heart Failure Patients
This study aims to determine if patients with higher BMI can tolerate higher doses of Entresto (sacubitril/valsartan) and experience better symptomatic and functional outcomes compared to patients with lower BMI.
- Trial name
- BETTER-HF (NCT06439069)
- Where
- Lithuania
- Volunteers
- 340 people
- Sponsor
- Lithuanian University of Health Sciences
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