Clinical trials: Heart Failure, Unspecified
Heart Failure
Use of Telemonitoring to Facilitate Heart Failure Medication Titration
Heart failure (HF) is a common diagnosis with high prevalence, reduced life expectancy and a significant clinical and economic burden.
- Trial name
- Medly Titrate (NCT04205513)
- Testing
- Medly
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- University Health Network, Toronto
Heart Transplant Failure and Rejection, Heart Failure
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a…
- Conditions
- Heart Transplant Failure and Rejection, Heart Failure, Heart Diseases, Heart Failure，Congestive
- Trial name
- HEARTBiT (NCT03575910)
- Where
- 4 sites in United States, Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Heart Failure With Preserved Ejection Fraction
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF
This study is trying to find out how best to improve common measures of health and survival in those diagnosed with heart failure with preserved ejection fraction (HFpEF) through the implementation of 4 weeks of an exercise…
- Trial name
- NCT05236413
- Testing
- High Intensity Interval Exercise, Dietary Approaches to Stop Hypertension (DASH) Diet, Exercise + DASH Diet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Virginia
Heart Failure
The Effects of Self-monitoring With a Mobile Application in Heart Failure
In the United States, about 40 percent of heart failure (HF) patients are readmitted within 1-year following their first admission for HF and hospitalization accounts for approximately 70 percent of the costs of HF management.
- Trial name
- NCT03149510
- Testing
- Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Michigan
Heart Failure, Resynchronization Therapy
Acute Feedback on Left ventrIcular Lead Implantation Location for Cardiac Resynchronization Therapy
Exploratory, prospective, interventional, non-randomized single-center research study to compare metrics derived from 2 or 3-D reconstructions of lead movement, bioimpedance and VCG to augmentation of left ventricular…
- Conditions
- Heart Failure, Resynchronization Therapy, Assessment of Acute CRT Response
- Trial name
- CCI impact (NCT01996397)
- Testing
- Cardiac resynchronization therapy device implantation
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- Oslo University Hospital
Chronic Heart Failure (CHF)
Effect of a Structured Nursing Intervention Incorporating Sleep Hygiene and Cognitive-Behavioral Strategies on Sleep Quality Among Patients With Chronic Heart Failure
This study aims to evaluate the effectiveness of a structured nursing intervention incorporating sleep hygiene education and cognitive-behavioral strategies on improving sleep quality among patients with chronic heart failure.
- Trial name
- Heart failure (NCT07747597)
- Testing
- Structured Nursing Intervention Incorporating Sleep Hygiene and Cognitive-Behavioral Strategies
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Zaytoonah University of Jordan
Edema Due to Heart Failure or Cirrhosis
A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric Patients
This is a 2-part, 2 periods per part, open-label study with spironolactone oral suspension in pediatric patients with edema due to HF or hepatic cirrhosis.
- Trial name
- NCT06021860
- Testing
- Spironolactone Oral Suspension
- Volunteers
- 96 people
- Sponsor
- CMP Development, LLC
Cardio-Renal Syndrome, Coronary Angiography
Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention
As a single center, retrospective observation study in Guangdong Institute of Cardiovascular Diseases, this study included the main study population of patients who underwent coronary angiography and / or coronary intervention…
- Conditions
- Cardio-Renal Syndrome, Coronary Angiography, Coronary Artery Disease, Kidney Diseases
- Trial name
- NCT04407936
- Where
- China
- Volunteers
- 88,938 people
- Sponsor
- Guangdong Provincial People's Hospital
Heart Failure
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal Function
A study to assess the safety, tolerability, and pharmacokinetics of AMG 986 given orally as a single dose to healthy participants and participants with severely impaired kidney function.
- Trial name
- NCT03318809
- Testing
- AMG 986
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amgen
Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction
Lokelma for RAAS Maximisation in CKD & Heart Failure.
Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of…
- Conditions
- Chronic Kidney Diseases, Heart Failure With Reduced Ejection Fraction, Hyperkalemia, ACE Inhibitor Induced Hyperkalaemia
- Trial name
- LIFT (NCT05004363)
- Testing
- Lokelma Oral Product
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- St George's, University of London
Chronic Heart Failure
VAccination to Improve Clinical outComes in Heart Failure Trial: a Feasibility Study (VACC-HeFT)
A multi-center, prospective, randomized, open-label blinded-endpoint trial in patients with heart failure will be conducted; 20 will be assigned to the standard dose vaccine dose and 20 patients to high dose influenza vaccine.
- Trial name
- VACC-HeFT (NCT02268500)
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Wisconsin, Madison
Congestive Heart Failure
REGISTRY EVALUATION OF VITAL INFORMATION FOR VADs IN AMBULATORY LIFE
REVIVAL will establish a prospective, observational, multicenter patient cohort in ambulatory patients with chronic, advanced, systolic heart failure that will provide a greater understanding of their clinical trajectory (rates…
- Trial name
- REVIVAL (NCT01369407)
- Testing
- No Intervention
- Where
- 21 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Michigan
Diastolic Heart Failure, Hypertensive Heart Disease
Physiological Effects of Grape Seed Extract in Diastolic Heart Failure
Diastolic heart failure (also known as "heart failure with normal ejection fraction" or "heart failure with preserved ejection fraction") occurs even though the heart muscle's pumping function is normal.
- Conditions
- Diastolic Heart Failure, Hypertensive Heart Disease, Heart Failure With Preserved Ejection Fraction, Hypertension
- Trial name
- GRAPEVINE-HF (NCT01185067)
- Testing
- grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Chronic Heart Failure
HVAD(TM) SMART 1.0 Study
The purpose of HVAD Smart 1.0 study is to collect HVAD device data (i.e., waveform + logfile + pump parameter) in various clinical conditions (e.g., routine follow-up visits, experiencing adverse events) to support development of…
- Trial name
- NCT04854200
- Testing
- Medtronic HeartWare ™ HVAD™ System
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Blood Pressure, Heart Failure
Wrist Worn Blood Pressure Measurement
In this study, the investigators are testing the accuracy of a wrist-worn measurement device by comparing its blood pressure measurement to arterial line (A-line) blood pressure monitors.
- Conditions
- Blood Pressure, Heart Failure, Advanced Heart Failure, Heart Failure，Congestive
- Trial name
- NCT03919136
- Testing
- Wrist-worn measurement device (LiveMetric)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- LiveMetric S.A.
Heart Failure
CRUSH STUDY: Calculating Readmission Risk by Ultrasound for Heart Failure Failure Study
This is a study to determine if two ultrasound measures (Corrected Flow Time and B-Lines) can predict patients at higher risk of readmission within 30 days of hospital discharge for decompensated heart failure.
- Trial name
- CRUSH (NCT02996032)
- Testing
- Vascular and Pulmonary Ultrasound
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Boston Medical Center
Heart Failure
PROMs From GEstIC Heart Failure Patients
Heart failure (HF) is a chronic condition with substantial morbidity, and understanding its effects on patients' quality of life is essential.
- Trial name
- PROFIC-HF (NCT06938698)
- Testing
- PROM collection
- Where
- Portugal
- Volunteers
- 155 people
- Sponsor
- Centro Hospitalar do Porto
Heart Failure
REDUCE LAP-HF RANDOMIZED TRIAL I
A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure.
- Trial name
- NCT02600234
- Testing
- Inter-Atrial Shunt Device, Intracardiac Echo
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 44 people
- Sponsor
- Corvia Medical
Diastolic Heart Failure
A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure
The aim of this study was to determine whether long-term (≥ 6 months at the target dose) blockade of ETA receptors using sitaxsentan showed functional benefit in subjects with chronic Heart Failure and an Left Ventricular…
- Trial name
- NCT00303498
- Testing
- Sitexsentin sodium
- Where
- 52 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Pfizer
Coronary Artery Disease, Coronary Heart Disease
Gamification to Increase Mobility in the Hospital
Low mobility is a mediator for poor outcomes of hospital care. Wearable devices will be used and 2-way texting via patient smartphones to monitor patients' physical activity during hospitalization with and without gamification to…
- Conditions
- Coronary Artery Disease, Coronary Heart Disease, Hypertension, Diabete Mellitus
- Trial name
- Level Up (NCT04300764)
- Testing
- Gamification Intervention
- Where
- United States
- Sponsor
- University of Pennsylvania
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