Clinical trials: Heart Failure, Unspecified
Heart Failure
Evaluation of the Entresto Effect on Sympathic Nervous System in Patient With Heart Failure
The hyperactivation of the sympathetic nervous system is a feature of the heart failure and the determinants of disease progression and risk of sudden cardiac death.
- Trial name
- B2AN-SNS (NCT02787798)
- Testing
- valsartan/sacubitril 100 mg, valsartan/sacubitril 200 mg, Microneurography
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Toulouse
MRI, Acquired Heart Disease
Noninvasive Imaging of Heart Failure: A Pilot Study
Background: Heart failure is a common cardiovascular disorder whose incidence increases with age, affecting up to 10% of people older than 65 years of age.
- Conditions
- MRI, Acquired Heart Disease, Myocardial Fibrosis
- Trial name
- NCT01160471
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Failure, Acute Myocardial Infarction
Eplerenone in Heart Failure Treatment
Beta-blockers should be administered to all patients with heart failure stage II to IV according to NYHA.Beta-blockers reduce mortality and hospitalizations and improve the operational phase for all categories of patients with…
- Conditions
- Heart Failure, Acute Myocardial Infarction, Hypertension
- Trial name
- INOSET (NCT02344199)
- Where
- 3 sites in Greece
- Volunteers
- 450 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Heart Failure, Remote Monitoring
Strategy TO Prevent Decompensated Heart Failure
The goal of this prospective, multicenter, single-arm, open-label clinical trial (Strategy TO Prevent Decompensated Heart Failure) is to evaluate the 12-month incidence of heart failure hospitalization (HFH) and all cause…
- Trial name
- #STOP-DHF (NCT06641921)
- Testing
- Seerlinq Telemedical Monitoring System
- Where
- Slovakia
- Volunteers
- 330 people
- Sponsor
- Seerlinq s. r. o.
Acute Myocardial Infarction, Heart Failure
"ESTIMATION Study" for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction
The investigators hypothesised that endocardial stem cells implantation following after percutaneous coronary intervention (PCI) could reduce the scar formation and increase reverse remodeling in patients with primary acute…
- Trial name
- ESTIMATION (NCT01394432)
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cardiorenal Syndrome
The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.
In double-blind clinical trial, determine renal recovery with two different furosemide strategies in patients with type 1 cardiorenal syndrome.
- Trial name
- NCT04393493
- Testing
- Furosemide intravenous solution, Chlortalidone, Spironolactone
- Where
- 2 sites in Mexico
- Volunteers
- 80 people
- Sponsor
- Hospital Civil de Guadalajara
Cardiomyopathy, Dilated, Heart Failure
The Persistence of Autoantibody Neutralisation by BC 007 in Patients With Chronic HFrEF and Autoantibodies Against the Beta1-Adrenergic Receptor
Chronic heart failure (CHF) is one of the major causes of death in Western societies. Evidence has accumulated that functionally active autoantibodies directed against the beta1 adrenergic receptor (β1 AAb) are of…
- Conditions
- Cardiomyopathy, Dilated, Heart Failure, Autoantibodies
- Trial name
- NCT04192214
- Testing
- BC 007
- Where
- 3 sites in Serbia
- Volunteers
- 30 people
- Sponsor
- Berlin Cures GmbH
Inpatients and Outpatients With Routine 12-lead ECG
Personalized Risk Identification and Management for Arrhythmias and Heart Failure by ECG and MRI
Prevention of myocardial functional deterioration and sudden cardiac death among individuals of intermediate risk remains one of the most elusive frontiers of contemporary medicine.
- Trial name
- PRIMERI (NCT01353131)
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Johns Hopkins University
Adherence, Medication, Adherence, Treatment
Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in Heart Failure With Reduced Ejection Fraction (HFrEF)
Heart failure with reduced ejection fraction (HFrEF) remains a major public health challenge with substantial morbidity and mortality despite the availability of effective guideline-directed medical therapy (GDMT).
- Conditions
- Adherence, Medication, Adherence, Treatment, Heart Failure
- Trial name
- VISUALIZE-PRO (NCT07505511)
- Testing
- Intervention: Visual Adherence Support (VISUALIZE-Pro)
- Volunteers
- 100 people
- Sponsor
- University of Giessen
Heart Failure and Preserved Ejection Fraction, Obesity & Overweight
eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF
The goal of this clinical trial is to learn if a digital lifestyle education program improves exercise capacity in adults who have heart failure with preserved ejection fraction (HFpEF) and overweight or obesity.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Obesity & Overweight, Heart Failure
- Trial name
- ELITE-HFpEF (NCT07661732)
- Testing
- Digital lifestyle education program, Usual Care
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Heart Failure
Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)
The purpose of this study was to generate effectiveness data of Angiotensin receptor neprilysin inhibitor (ARNI), in the Chinese Heart failure with reduced ejection fraction (HFrEF) patients with implantable cardioverted…
- Trial name
- RHYTHM (NCT04491136)
- Testing
- ACEI/ARB, ARNI
- Where
- 23 sites in China
- Volunteers
- 201 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Heart Failure, Fear of Physical Activity
Measuring Fear of Physical Activity in Patients With Heart Failure
The study's aims are twofold: First, to examine physiological correlates of fear of physical activity (PA) and second, to examine correlates between fear of PA and interoceptive abilities in patients with chronic heart failure…
- Trial name
- NCT03119298
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Trier
Heart Failure, Cardiac Resynchronization Therapy
Prospective Multicentric Study Comparing the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization Therapy Recipients
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with systolic heart failure and bundle branch block, improving functional capacity, quality of life and reducing morbi-mortality.
- Trial name
- 3 STIM (NCT03779802)
- Testing
- Device programming of ABBOTT CRT pacemaker or defibrillator
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- CMC Ambroise Paré
Heart Failure, Cardiomyopathy, Dilated
Therapy to Maintain Remission in Dilated Cardiomyopathy
One third of patients diagnosed with heart failure demonstrate left ventricular reverse remodelling and recovery of cardiac function following a period of medical therapy.
- Conditions
- Heart Failure, Cardiomyopathy, Dilated, Cardiomyopathies, Heart Diseases
- Trial name
- TRED-HF2 (NCT06091475)
- Testing
- Other
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Heart Failure
Atrioventricular Node Ablation in Patients With Atrial Fibrillation and Moderate Chronic Heart Failure
The purpose of this study is to determine whether cardiac resynchronization therapy (CRT) is superior to interventricular right ventricle (RV) septal pacing in respect of reverse remodeling (LV ESD) and morbidity in patients with…
- Trial name
- VISTA (NCT01512381)
- Testing
- Implantation of CRT device, Implantation of conventional VVI(R) pacemaker
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Heart Failure
Impact of Cardiac Rehabilitation Adapted for Patients With Heart Failure
The aim of the study is to evaluate whether a tailored cardiac rehabilitation program, initiated during hospitalization and continued after discharge, can improve functional capacity, mobility, and quality of life in patients…
- Trial name
- RAP-IC (NCT07350941)
- Testing
- Cardiac rehabilitation program
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Puerta de Hierro University Hospital
Heart Failure
Heart Sounds Measurement Using the Wearable Cardioverter Defibrillator (HS-WCD) Study
A prospective, validation study to evaluate the data accuracy of heart sounds recorded by the LifeVest® Wearable Cardioverter Defibrillator (WCD).
- Trial name
- NCT02825966
- Testing
- AUDICOR then LifeVest then AUDICOR
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Zoll Medical Corporation
Heart Failure
Speech-to-text Tool for Heart Failure Patient-Reported Data
The goal of this study is to see whether this type of Artificial Intelligence (AI) Voice Assistant can reliably capture patient-reported health information to support communication between patients and their healthcare team.
- Trial name
- NCT07217366
- Testing
- Artificial intelligence speech-to-text tool
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Pulmonary Hypertension
PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol)
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature leading to elevated pulmonary pressure and right ventricular (RV) dysfunction with heart failure.
- Trial name
- PAHTCH (NCT01586156)
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Heart Failure
Inspiratory Muscle Training in HFpEF
This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.
- Trial name
- NCT06510231
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mayo Clinic
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