Clinical trials: Heart Failure，Congestive
Heart Failure
High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure
This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the…
- Trial name
- NCT06647667
- Testing
- HIITS, MICT
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Heart Failure, Myocardial Ischemia
METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial)
The aim of the study is to evaluate the efficacy of methotrexate to improve physical capacity in patients with symptomatic ischemic heart failure.
- Trial name
- METIS (NCT00759811)
- Testing
- Methotrexate
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Ventricular Arrythmia, Lead
Safety and Performance of INVICTA Ventricular DF4 LEADS With Active Fixation-(APOLLO)
The primary objective of this study is to assess the safety and key electrical performance of the INVICTA leads equipped with DF4 connector: ACTIVE fixation type models (single and dual coil: INVICTA 1CR, INVICTA 2CR)
- Conditions
- Ventricular Arrythmia, Lead, ICD, Heart Failure
- Trial name
- APOLLO (NCT04590144)
- Testing
- INVICTA lead
- Where
- 45 sites in Austria, France and 6 more
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
End-stage Heart Failure
Mechanical Circulatory Support Korea Post Market Surveillance Study (PMS)
Medtronic is sponsoring this Mechanical Circulatory Support (MCS) Korea Post-Market Surveillance (PMS) to evaluate the safety and performance of the HeartWare Ventricular Assist Device System (HVAD® System) when used in routine…
- Trial name
- NCT04543747
- Testing
- HeartWare Ventricular Assist Device
- Where
- 2 sites in South Korea
- Volunteers
- 77 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Heart Failure With Reduced Ejection Fraction
Left vs Left Randomized Clinical Trial
The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality)…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB
- Trial name
- NCT05650658
- Testing
- His/LBBP, BiVP
- Where
- 71 sites in United States, Canada
- Volunteers
- 2,136 people
- Sponsor
- Baylor College of Medicine
Acute Kidney Injury, Acute Heart Failure
Predictors of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure in Emergency
Acute Decompensated Heart Failure ADHF is one of the leading causes of hospitalization. ADHF is a growing global health problem affecting more than 26 million individuals worldwide Acute Kidney Injury AKI is a common event in the…
- Trial name
- NCT06463964
- Testing
- Serum Creatinine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Congestive Heart Failure, Diabetes Mellitus
Glycemic Control and Variability for Congestive Heart Failure Exacerbation
High glucose as well as fluctuations (rapid swings) in blood glucose can contribute to severe hospital complications and even death.
- Trial name
- NCT00812487
- Testing
- Intravenous insulin, Subcutaneous insulin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Kathleen Dungan
Healthy Volunteers, Heart Failure
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict…
- Conditions
- Healthy Volunteers, Heart Failure, Aortic Stenosis, Ischemic Heart Disease
- Trial name
- NCT00830726
- Testing
- Pharmacologic and mechanical heart failure treatment, Aortic valve replacement, Revascularisation in Acute Coronary Syndrome
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Congestive Heart Failure
Post Approval Registry of Corox OTW, Endocardial, Left Ventricular Steroid Lead, Bipolar
The objective of this study is to confirm the long-term safety and reliability of the Corox OTW BP left ventricular (LV) pacing lead.
- Trial name
- CELESTIAL (NCT00810264)
- Testing
- CRT Therapy - LV Lead Registry
- Where
- 86 sites in United States
- Volunteers
- 2,499 people
- Sponsor
- Biotronik, Inc.
Heart Failure
Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF)
This study will compare the ability of the heart to increase its contractile performance during stress in patients with a history of heart failure without systolic dysfunction and in controls.
- Trial name
- DobStress (NCT00585806)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hypertension
CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression
This study will consist of middle-aged Caucasian non-failing subjects with high blood pressure who are homozygous for a gene that confers increased risk of developing heart failure, the Glycine 83 variant of the Ka renal chloride…
- Trial name
- NCT01275352
- Testing
- Eplerenone
- Where
- 2 sites in United States
- Sponsor
- Washington University School of Medicine
Myocardial Infarction
The Time Delay Correlated With LV Functions and Heart Failure Incidence in STEMI?!
To find out if the time delays between the first medical contacts till the device has an impact on LV functions estimated by transthoracic Echocardiography and if it's correlated to heart failure incidence in non-diabetic…
- Trial name
- NCT05097755
- Volunteers
- 345 people
- Sponsor
- mustafa Zayan Abdelsayed Mohamed
Congestive Heart Failure, Diabetes
Does Access to an EHR Patient Portal Influence Chronic Disease Outcomes?
The purpose of this study is to determine if patients with congestive heart failure, diabetes or secondary cardiovascular diseases, who access HealthMedia's online tailored behavior change programs on the electronic health record…
- Conditions
- Congestive Heart Failure, Diabetes, Cardiovascular Disease
- Trial name
- NCT00147706
- Testing
- Tailored Healthmedia programs on EHR Patient Portal
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Robert Wood Johnson Foundation
Acute Coronary Syndrome, Heart Failure
Increasing Exercise and Decreasing Sedentary Behavior Among Patients in a Cardiac Rehabilitation Clinic
Cardiac rehabilitation patients often fail to exercise as prescribed on days they are not attending rehabilitation and there is a steep drop off in exercise following rehabilitation completion.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Other Cardiac Conditions Among Cardiac Rehabilitation Participants
- Trial name
- NCT02679599
- Testing
- B-MOBILE-CARDIAC smartphone application, Cardiac rehabilitation as usual
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The Miriam Hospital
Heart Failure
Benefits of µCor in Ambulatory Decompensated Heart Failure
Subjects meeting the inclusion/exclusion criteria will wear the µCor for at least 90 days. During the study, clinic follow up will occur every 30 days.
- Trial name
- BMADHF (NCT03476187)
- Testing
- µCor
- Where
- 61 sites in United States, Austria and 1 more
- Volunteers
- 257 people
- Sponsor
- Zoll Medical Corporation
Cardiovascular Diseases, Coronary Disease
Studies of Left Ventricular Dysfunction (SOLVD)
To determine if enalapril treatment of left ventricular dysfunction (LVD) due to ischemic or hypertensive heart disease led to reduced mortality and morbidity in symptomatic and asymptomatic patients.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Heart Failure
- Trial name
- NCT00000516
- Testing
- enalapril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coagulation
Left Ventricular Assist Device (LVAD) Specialized Centers of Clinically Orientated Research (SCCOR) Coagulation - Acute Intrinsic Pathway Antagonist (IPA)
The purpose of this study is to determine if post-operative administration of intrinsic pathway antagonist (TTP889) in patients on Left Ventricular Assist Device (LVAD) support will result in a 50% reduction of thrombin…
- Trial name
- NCT00909298
- Testing
- TTP889
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- vTv Therapeutics
Phospholamban R14del Cardiomyopathy, Heart Failure
Identification of Disease Specific Pathways and Modifiers in Phospholamban R14del Cardiomyopathy
Background A specific mutation in phospholamban (the PLN R14del mutation), has its origin in the northern parts of the Netherlands (Figure) and causes a severe lethal dilated and/or an arrhythmogenic cardiomyopathy.
- Conditions
- Phospholamban R14del Cardiomyopathy, Heart Failure, Cardiomyopathy, Familial
- Trial name
- DECIPHER-PLN (NCT04978987)
- Where
- Netherlands
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Acute Heart Failure
Prospective Registry of Acute Heart Failure
Context: Heart failure is associated with a high morbidity and mortality rate and represents a significant worldwide public health burden.
- Trial name
- NCT02444416
- Testing
- blood sample
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- Sebastian Carballo
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
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