Clinical trials: Heart Failure (HF)
HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction
Exercise-Based Cardiac Rehabilitation for Patients With Heart Failure With Preserved Ejection Fraction (EMPOWER-HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a common condition among older adults. It is associated with frequent hospitalizations, impaired functional capacity, reduced quality of life, and high healthcare…
- Conditions
- HF - Heart Failure, HFpEF - Heart Failure With Preserved Ejection Fraction, Readmission Rates, Exercise Training
- Trial name
- EMPOWER-HFpEF (NCT07727096)
- Testing
- Exercise-Based Cardiac Rehabilitation, Guideline-Directed Medical Therapy
- Where
- Spain
- Volunteers
- 390 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Heart Failure With Reduced Ejection Fraction (HF-rEF)
The Effectiveness and Safety of Artificial Intelligence(AI)-Assisted Medical Treatment Decision Support System Compared to Conventional Care in HFrEF Patients
This clinical trial aims to find out if using an artificial intelligence (AI) decision support system can help doctors better manage medications for people with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT07380555
- Testing
- artificial intelligence (AI) decision support system
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure
Early Care After Discharge of HF Patients
After decompensated heart failure, a number of patients have high risk of early rehospitalization as well as death. Specialized medical management for a short period but very early after discharge could be critical for optimizing…
- Trial name
- ECAD-HF (NCT01820780)
- Testing
- Natriuretic peptides levels to J7 and J14, Consultations specialized to J7 and J14, Phone calls in 6 months and 12 months
- Where
- France
- Volunteers
- 507 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
CHF, ADHF
Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)
The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of…
- Conditions
- CHF, ADHF, Control
- Trial name
- SEAL-HF (NCT06169540)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Diabetes Mellitus, Type 2
Insulin Treatment in Diabetic Older People With Heart Failure.
Cardiac failure (HF) and type 2 diabetes mellitus (T2DM) are two clinical conditions with a significant impact on public health worldwide.
- Trial name
- Insulin-HF (NCT03665350)
- Testing
- Insulin
- Where
- 3 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Cardiac Rehabilitation, Heart Failure
Accelerated (Intensive) Cardiac Training for Heart Failure Patients
The purpose of this study is to see if patients undergoing accelerated Intensive Cardiac Rehabilitation (ICR) (2 weeks after discharge) will improve exercise performance as well as on measures of quality of life after a cardiac…
- Trial name
- ACT-HF (NCT07858318)
- Testing
- Early Referral
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Heart Failure
Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response
The purpose of this study is to do the work that is necessary and sufficient for setting up an appropriate multi-center, randomized clinical trial (RCT) of a new therapy for heart failure: inorganic nitrate.
- Trial name
- NCT02797184
- Testing
- KNO3, potassium nitrate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Heart Failure
RESpiration deTection From Implanted Cardiac Devices in Subjects With Heart Failure (REST-HF)
The purpose of this prospective, non-randomized, single-arm, research study is to evaluate the accuracy of acutely extracting respiratory rate and tidal volume from implanted cardiac device impedance in subjects with heart…
- Trial name
- REST-HF (NCT03087084)
- Testing
- Cardiac Pacing and Impedance Measurement system
- Where
- 3 sites in Belgium, South Africa
- Volunteers
- 25 people
- Sponsor
- Medtronic BRC
Acute Decompensated Heart Failure
DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response to Diuretics
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
- Trial name
- NCT05876078
- Testing
- Doraya catheter
- Where
- 10 sites in Germany, Italy and 3 more
- Volunteers
- 25 people
- Sponsor
- Revamp Medical Ltd.
Heart Failure
Multidimensional Impact of Telemonitoring in Heart Failure (IMPACT-HF)
The goal of this clinical trial is to know if telemonitoring and telematic follow-up reduces the healthcare resources utilization, healthcare costs and non-healthcare costs of patients with high-risk heart failure.
- Trial name
- IMPACT-HF (NCT05653726)
- Testing
- Telemonitoring follow-up using medical devices and telematic consultations
- Where
- Spain
- Volunteers
- 390 people
- Sponsor
- Hospital Universitario 12 de Octubre
Heart Failure
ENABLE (Educate, Nurture, Advise, Before Life Ends) Intervention for Heart Failure (HF) Patients and Their Caregivers in Singapore
To pilot a culturally adapted version of ENABLE (6-month program) for Heart Failure (HF) patients and caregivers in the inpatient and outpatient setting in Singapore.
- Trial name
- ENABLE-HF-SG (NCT05211882)
- Testing
- Immediate ENABLE nurse coaching, on top of usual care, Usual Care
- Where
- 2 sites in Singapore
- Volunteers
- 125 people
- Sponsor
- National Cancer Centre, Singapore
Heart Failure
ADHESION TO THERAPEUTIC STRATEGIES FOR OUTPATIENTS WITH HEART FAILURE - ADhesion-HF
The purpose of this study is to verify the impact of the educational intervention in the adhesion to therapeutic strategies for patients with heart failure.
- Trial name
- ADhesion-HF (NCT02230150)
- Testing
- Adhesion-HF
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of Bahia
Heart Failure
Home-HF: Evaluation of Patients With Heart Failure Using Home Telemonitoring
This project, using home monitoring for the signs and symptoms of heart failure, aims to empower patients to be actively involved in their care and provide rapid access to healthcare services and advice when needed.
- Trial name
- NCT00312884
- Testing
- HomMed Telemonitoring System
- Where
- 3 sites in United Kingdom
- Volunteers
- 182 people
- Sponsor
- Imperial College London
Atrial Fibrillation, Heart Failure
Danish Evaluation of Early Catheter Ablation for Atrial Fibrillation in Patients With Heart Failure
The DanAblate-HF trial will investigate whether early catheter ablation treatment for atrial fibrillation in patients with heart failure is superior to standard treatment.
- Trial name
- DanAblate-HF (NCT06560047)
- Testing
- Catheter ablation
- Where
- 6 sites in Denmark
- Volunteers
- 1,616 people
- Sponsor
- Aalborg University Hospital
Heart Failure, Congestive
X-Change HF - Exchange of the Existing Pacemaker/ICD in Bradycardia Patients Suffering From Heart Failure
The goal of X-Change HF is to estimate the effect of biventricular stimulation in patients who need antibradycardia ventricular stimulation (more than 80%); are eligible for the exchange of an old pacemaker or implantable…
- Trial name
- NCT00157846
- Testing
- CRT-P or CRT-D Device
- Where
- 10 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Acute Heart Failure
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and mildly reduced or preserved left ventricular ejection fraction.
- Trial name
- REDEFINE-HF (NCT06008197)
- Testing
- Finerenone
- Where
- 356 sites in United States, Argentina and 24 more
- Volunteers
- 5,200 people
- Sponsor
- Colorado Prevention Center
Heart Failure
The VO2 Increase With Testosterone Addition - Heart Failure (VITA-HF) Trial
Evaluate the efficacy and safety of testosterone supplementation on functional capacity, biomarkers, quality of life and clinical outcomes for patients with heart failure.
- Trial name
- VITA-HF (NCT01469988)
- Testing
- Testosterone
- Where
- 7 sites in Canada
- Volunteers
- 318 people
- Sponsor
- University of Alberta
Cardiovascular Diseases
CAB Versus Medical Therapy in Patients With AF and HF With Different EF Categories
This study is to assess the effectiveness and safety of cryoballoon ablation comparing with medical therapy in patients with atrial fibrillation and heart failure with different ejection fraction categories.
- Trial name
- NCT05364866
- Testing
- Antiarrhythmic drug Therapy, cryoballoon ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of Nantong University
Cardiotoxicity, Pediatric Cancer
Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity.
- Conditions
- Cardiotoxicity, Pediatric Cancer, Heart Failure
- Trial name
- CATCH-HF (NCT04262830)
- Testing
- Cardiac magnetic resonance imaging (MRI), Accelerometer physical activity monitoring
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Hari Narayan
Heart Failure
Endovascular NeuromoDulation Treatment fOr Heart Failure Patients (ENDO-HF)
The purpose of the ENDO-HF study is to determine the safety \& performance of the Harmony System for the treatment of heart failure
- Trial name
- NCT02633644
- Testing
- Harmony System
- Where
- 5 sites in Belgium, Croatia and 2 more
- Volunteers
- 30 people
- Sponsor
- Enopace Biomedical